Side effects of vaccines in the form of tinnitus and hearing loss are not uncommon.
Various reports talk about temporary tinnitus and other audio-vestibular effects after
taking different types of vaccination shots such as hepatitis B, H1N1, measles, and
rabies.[1]–[3]As the COVID-19 vaccination program continues to be rolled out at pace around the
globe, with increasing numbers of people being encouraged to undertake vaccination
shots, a similar challenge seems to be on the rising.
Reports of triggering tinnitus in patients who received COVID-19 vaccines have been
documented.[4],[5] Parrino et al in 2021 reported that two out of three patients in their study had
no history of audio-vestibular problems before vaccination.[5] Tinnitus was classified as catastrophic in two and as severe in one of them, according
to the Tinnitus Handicap Inventory. Although the tinnitus reduced in severity after
drug therapy in two of them, one did not show any significant changes in the perception
of tinnitus even after the drug therapy.[5] The vaccine used in the above-reported study were mRNA vaccine injections.
A mixture of people who have received mRNA vaccines (Pfizer/BioNTech and Moderna)
and adenovirus-based vaccine (Johnson & Johnson) along with the viral vector vaccine
Vaxzevria by Astrazeneca are experiencing the same adverse event of tinnitus.[4] Vaccine Adverse Event Reporting System (VAERS) in the US database also reports of
tinnitus among COVID-19 recipients of vaccines from Pfizer-BioNTech and Moderna. Tinnitus
has been classified as a “very rare” side effect under the Guidelines for Clinical-Safety
Information on Drugs by the Council for International Organizations of Medical Sciences
(CIOMS). Although it is very rare, the impact of tinnitus on individuals is severe.
To combat the COVID-19 pandemic, different vaccines are on trial and have been coming
up in the market. There is a need to keep surveillance on each of these vaccines to
monitor the side effects such as tinnitus and audio-vestibular problems. It would
also be interesting to find out how does these vaccines unfolding persons already
facing tinnitus problems. Looking at the prevalence of tinnitus worldwide, such a
side effect can highly discourage patients to take vaccines. The yellow card scheme
of the Medicines and Healthcare Products Regulatory Agency should be adopted everywhere
for recording such suspected side effects from vaccines.
One of the aims of this study is to inform the audiologists to be more vigilant with
the patients who have received COVID-19 vaccines and come to the clinics with the
complaint of tinnitus. As the tinnitus induced is not vaccine-specific, it could be
possible that it is an anxiety-related reaction. People are more stressed and anxious
in this pandemic, which might be an aggravating factor for the tinnitus symptom they
encounter after vaccination as all the vaccines are novel, and people are skeptical
about its efficiency and side effects. Thus, thorough counseling about the vaccines
should be taken up as a protocol to help them get rid of all the fear and anxiety
related to it. Another side of the coin points toward vaccine-induced tinnitus. It
could be related to the similarity in composition or its mechanism of action that
would potentially be responsible for the development of tinnitus. Tracking down the
possible mechanisms and ruling out whether the induced tinnitus vaccine specific or
not should be studied. Increased responsibility lies on the shoulders of ENTs and
audiologists as the pandemic evolves both in terms of virus variants and upcoming
vaccines.
