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Synlett
DOI: 10.1055/s-0043-1775460
DOI: 10.1055/s-0043-1775460
letter
Small Molecules in Medicinal Chemistry
A Novel Strategy for the Synthesis of N-Alkylated Oxindoles
Authors
Abstract
The synthesis of N-alkylated oxindoles remains an important focus in organic chemistry, due to their common occurrence in bioactive compounds and pharmaceutical agents. An efficient novel strategy for alkylating the oxindole scaffold at the N-1 position is described. By using (N-methylpyrrol-2-yl)methylidene as a protecting group for the competing C-3 position, this methodology provides a simple and mild procedure to convert various oxindoles into their corresponding N-alkylated and N-benzylated derivatives in moderate to good overall yields (up to 67%).
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0043-1775460.
- Supporting Information (PDF)
Publication History
Received: 23 December 2024
Accepted after revision: 27 February 2025
Article published online:
08 April 2025
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