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Exp Clin Endocrinol Diabetes 2020; 128(02): 77-81
DOI: 10.1055/s-0044-100376
Article
© Georg Thieme Verlag KG Stuttgart · New York

The Variation of Disulfides in the Progression of Type 2 Diabetes Mellitus

Merve Ergin
1   Department of Biochemistry, 25 Aralik State Hospital, Gaziantep, Turkey
,
Cevdet Aydin
2   Department of Endocrinology and Metabolism, Yildirim Beyazit University, Faculty of Medicine, Ankara, Turkey
,
Emine Feyza Yurt
3   Department of Biochemistry, Yildirim Beyazit University, Faculty of Medicine, Ankara, Turkey
,
Bekir Cakir
2   Department of Endocrinology and Metabolism, Yildirim Beyazit University, Faculty of Medicine, Ankara, Turkey
,
Ozcan Erel
3   Department of Biochemistry, Yildirim Beyazit University, Faculty of Medicine, Ankara, Turkey
› Author Affiliations
Further Information

Publication History

received 05 August 2017
revised 25 December 2017

accepted 08 January 2018

Publication Date:
29 January 2018 (online)

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Abstract

Aim The purpose of this study was to examine thiol-disulfide balance in patients with type 2 diabetes mellitus.

Methods This study included 32 subjects with known type 2 diabetes mellitus without complications, 30 patients with type 2 diabetes mellitus with complications, 28 newly diagnosed patients with type 2 diabetes mellitus, and 45 healthy individuals. Thiol-disulfide profile tests were quantified in all groups.

Results Compared to the control group, patients in each of the diabetic groups had significantly lower native and total thiol levels, higher disulfide levels, and higher disulfide/native thiol and disulfide/total thiol ratios (p<0.05 for all). Disulfide levels were significantly lower in the newly diagnosed group than in other diabetic groups (p<0.05). There were significant associations between glycemic parameters and thiol-disulfide tests (p<0.05).

Conclusions A disequilibrium between thiol-disulfide pairs occurs in patients with type 2 diabetes mellitus, and a gradual increase to disulfide levels may contribute to the disease’s severity. Deteriorated thiol-disulfide homeostasis may be relevant to the pathophysiology of type 2 diabetes mellitus.

Key words

disulfide - oxidative stress - thiol-disulfide homeostasis - type 2 diabetes mellitus
 

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