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Semin Respir Crit Care Med 2024; 45(03): 397-410
DOI: 10.1055/s-0044-1785675
DOI: 10.1055/s-0044-1785675
Review Article
Pulmonary Manifestations of Sjögren's Disease
Abstract
Sjögren's disease (SjD) is a chronic, progressive autoimmune condition of exocrine and extraglandular tissues. It can present with isolated disease characterized by lymphocytic infiltration of salivary or lacrimal glands, but in approximately one-third of the patients, lymphocytic infiltration extends beyond exocrine glands to involve extraglandular organs such as the lungs. Pulmonary complications have been reported to occur between 9 and 27% of patients with SjD across studies. Respiratory manifestations occur on a spectrum of severity and include airways disease, interstitial lung disease, cystic lung disease, and lymphoma. Lung involvement can greatly affect patients' quality of life, has a major impact on the overall prognosis, and frequently leads to alteration in the treatment plans, highlighting the importance of maintaining a high index of clinical suspicion and taking appropriate steps to facilitate early recognition and intervention.
Publikationsverlauf
Artikel online veröffentlicht:
15. April 2024
© 2024. Thieme. All rights reserved.
Thieme Medical Publishers, Inc.
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