Incidence, Risk Factors and Outcomes of Urinary Tract Infections among Patients Undergoing Thyroidectomy: Insights from the ACS-NSQIP

Keywords

thyroidectomy - urinary tract infection - morbidity - mortality

Introduction

Thyroidectomy is a common surgical procedure used to manage both benign and malignant thyroid pathologies. As the incidence of thyroid cancer continues to rise at a rate of over 5% annually, the increasing demand for thyroidectomies could pose a significant surgical burden.[1] Thyroidectomy is generally well-tolerated with a minimal morbidity rate.[2] However, complications such as recurrent laryngeal nerve injury, hematoma, and postoperative hypocalcemia may occur.[3]

Urinary tract infections (UTIs) represent a well-known postoperative complication across multiple surgical subspecialties. For instance, UTIs account for 40% of all healthcare-associated infections, making it a significant concern for healthcare professionals.[4] In addition to complicating prognosis for patients, UTIs also incur a significant financial burden. In fact, UTIs have cost over 450 million USD and resulted in more than 13,000 deaths annually in the last decades.[4] [5] [6] Given these serious implications, it is imperative to mitigate their risk among surgery patients and optimize care for patients with UTIs to reduce associated morbidity and mortality.

The incidence of postoperative UTIs among patients undergoing thyroidectomy is rare, with only 0.28% of cases reported in the literature.[7] As a result, there has been a lack of research on the risk factors and outcomes of UTIs in this patient population. To fill this gap, our study aims to evaluate the incidence, underlying risk factors, and postoperative outcomes of 30-day postoperative UTIs in adult patients undergoing thyroidectomy.

Methods

This retrospective cohort study was conducted in adherence with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline, utilizing the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database. The ACS-NSQIP partnering hospitals collect standardized, audited clinical data on patient characteristics, preoperative and intraoperative details, and postoperative complications for a predetermined, random sample of their patients. Postoperative outcomes are evaluated by qualified surgical clinical reviewers at each participating center for up to 30 days after the index operation, regardless of patient discharge status. These reviewers assess the patients' medical records, contact the involved clinicians, and reach out to patients as necessary to obtain the required ACS-NSQIP data elements. As this study utilized already deidentified data, it was exempted from review by the Ethics Review Committee at the Aga Khan University in Pakistan (reference ID: 2021–6794–19517).

Population

Our study population consisted of all adult patients (age ≥ 18 years) who underwent partial, subtotal/total, or completion thyroidectomies for any indication between January 1^st, 2005, and December 31^st, 2019. We identified these patients using current procedural terminology (CPT) codes ([Table 1]). We excluded patients who underwent emergency surgery and those with primary surgical specialty coded other than general surgery or otolaryngology.

Table 1 Included current procedural terminology codes

Procedure	CPT codes
Partial thyroidectomy	60210: Partial total lobectomy 60212: Partial total lobectomy with contralateral subtotal lobectomy 60220: Total thyroid lobectomy, unilateral; with or without isthmusectomy
Total/subtotal thyroidectomy	60225: Total thyroid lobectomy, unilateral; with contralateral subtotal lobectomy, including isthmusectomy 60240: Thyroidectomy, total or complete 60252: Thyroidectomy, total or subtotal for malignancy; with limited neck dissection 60254: Thyroidectomy, total or subtotal for malignancy; with radical neck dissection 60270: Thyroidectomy, including substernal thyroid; sternal split or transthoracic approach 60271: Thyroidectomy, including substernal thyroid; cervical approach
Completion thyroidectomy	60260: Thyroidectomy, removal of all remaining thyroid tissue following previous removal of a portion of thyroid

Abbreviation: CPT, current procedural terminology.

Measures

In the present study, both demographic and preoperative comorbidity variables were examined. Age, gender, and race were the demographic variables, while preoperative comorbidities included diabetes mellitus, functional health status, current smoking status, ventilator dependency, chronic obstructive pulmonary disease (COPD), congestive heart failure, hypertension necessitating medication, acute renal failure, dialysis, and steroid/immunosuppressant use for chronic conditions. Additionally, surgical variables such as American Society of Anesthesiologists (ASA) classification, wound classification, surgical indication, type of thyroidectomy, inpatient/outpatient status, and operative time were analyzed. The surgical indications were further classified as benign or malignant using the International Classification of Diseases, Ninth and Tenth Revisions (ICD-9-CM and ICD-10-CM, respectively).

Outcomes

The primary outcome of interest in this study was the development of UTIs within 30 days after the operation. Index markers for clinically diagnosing UTI included pyrexia (> 38° C), urinary urgency, frequency, dysuria, or suprapubic discomfort in the presence of a urine culture containing more than 100,000 colonies/mL and a maximum of 2 organism species. Alternatively, patients were required to have 2 of the aforementioned symptoms along with a positive dipstick test for leukocyte esterase or nitrates, pyuria greater than 10 white blood cells/mm³ or greater than 3 white blood cells/hpf of unspun urine, organisms visualized on urine gram stain, 2 urine cultures containing the same uropathogen >100 colonies/mL, or one urine culture containing less than 100,000 colonies/mL in a patient who had been prescribed an antibiotic.

Secondary outcomes of interest included all-cause mortality, surgical site infections (SSIs; superficial, deep, or organ/space), sepsis, septic shock, wound disruption, pneumonia, cerebrovascular accident (CVA) or stroke, cardiac arrest requiring cardiopulmonary resuscitation, myocardial infarction, unplanned reintubation, prolonged postoperative ventilator dependence of > 48 hours, progressive renal insufficiency, acute renal failure requiring dialysis, pulmonary embolism, deep venous thrombosis, and unplanned reoperation. Additionally, unplanned reoperation and prolonged length of stay (> 2 days) were also evaluated. Unplanned reoperation was not limited to the index hospital. This study further analyzed composites of these outcomes, namely any complication, infectious and non-infectious complications.

Statistical Analysis

Patients were first subdivided into UTI and non-UTI groups, and descriptive statistics were reported. Continuous variables were confirmed to have non-parametric distribution using the Kolmogorov-Smirnov test and were reported using median and interquartile ranges (IQRs), and then compared between the two groups using the Mann-Whitney U test. Categorical variables were described using frequencies and percentages and were compared between the groups using the χ2 tests or Fisher exact tests, as appropriate.

To further assess the factors associated with postoperative UTIs in thyroidectomy patients, binary logistic regression models were utilized. Similarly, multivariable models were computed for secondary outcomes, with the development of UTI as the main explanatory variable. Clinically relevant covariates occurring prior to the outcomes and with p < 0.25 on univariate analyses were used to adjust these regression models.

All statistical analyses were performed using two-sided tests with α < 0.05 as the threshold for significance. Adjusted odds ratios (ORs) along with 95% confidence intervals (CIs) were reported. Missing data were included in flowcharts and summary tables, which allowed denominators to remain consistent in calculations. The software used for the analyses was the IBM SPSS Statistics for Windows, version 23.0 (IBM Corp., Armonk, NY USA).

Results

A total of 180,373 thyroidectomy cases were included in the study ([Fig. 1]), with only 0.28% of patients developing a postoperative UTI. Among these cases, most were female patients, and other sociodemographic characteristics are described in [Table 2]. The UTI and non-UTI groups were compared, and the univariate analysis demonstrated several factors to be significantly associated with the incidence of UTIs. These factors included a higher ASA classification, dependent functional health status, diabetes mellitus, chronic steroid therapy, longer operative time, inpatient thyroidectomy, and wound contamination. Moreover, the composite pulmonary and cardiovascular disorders, as well as each of their individual components, were also significantly linked to the occurrence of UTIs.

Fig. 1 Cohort creation. Abbreviations: ACS-NSQIP, American College of Surgeons National Surgical Quality Improvement Program; PUF, participant use data file.

Table 2 Baseline characteristics, comorbidities, and operative variables stratified by urinary tract infection status

Variable	No UTI N = 179,883	UTI N = 490	p-value
Age, in years			< 0.001
18–40	41,878 (23.3%)	69 (14.1%)
40–60	80,993 (45.1%)	155 (31.7%)
> 60	56,858 (31.6%)	265 (54.2%)
Missing	154	1
Age/years*	52.0 (23.0)	61.0 (23.0)	< 0.001
Gender			0.016
Female	142,944 (79.5%)	411 (83.9%)
Male	36,939 (20.5%)	79 (16.1%)
Race			0.511
White	121,636 (78.5%)	340 (80.6%)
Black	23,362 (15.1%)	54 (12.8%)
American Indian or Alaska Native	699 (0.5%)	3 (0.7%)
Asian, Native Hawaiian, or Pacific Islander	9,182 (5.9%)	25 (5.9%)
Missing	25,004	68
BMI (kg/m2)			0.133
Healthy (18.5-24.9)	43,195 (24.2%)	108 (22.3%)
Underweight (< 18.5)	1,876 (1.1%)	10 (2.1%)
Overweight (25.0–29.9)	53,829 (30.1%)	151 (31.1%)
Obese (30 or higher)	79,676 (44.6%)	216 (44.5%)
Missing	1,307	5
BMI (kg/m2)*	29.1 (9.4)	29.1 (9.1)	0.765
ASA classification			< 0.001
ASA 1–2	123,710 (68.9%)	251 (51.4%)
ASA 3–5	55,869 (31.1%)	237 (48.6%)
Missing	304	2
Functional health status			< 0.001
Independent	178,247 (99.5%)	460 (95.4%)
Partially independent	791 (0.4%)	15 (3.1%)
Totally independent	105 (0.1%)	7 (1.5%)
Missing	740	8
Current smoker	25,604 (14.2%)	60 (12.2%)	0.208
Diabetes mellitus	23,139 (12.9%)	97 (19.8%)	< 0.001
Pulmonary disease	3,865 (2.1%)	35 (7.1%)	< 0.001
COPD	3,823 (2.1%)	30 (6.1%)	< 0.001
Ventilator dependence	48 (0.0%)	7 (1.4%)	< 0.001
Cardiovascular disease	68,273 (38.0%)	258 (52.7%)	< 0.001
Hypertension	68,184 (37.9%)	258 (52.7%)	< 0.001
Congestive heart failure	408 (0.2%)	6 (1.2%)	0.001
Renal disease	729 (0.4%)	2 (0.4%)	0.727
Acute renal failure	72 (0.0%)	1 (0.2%)	0.180
Currently on dialysis	695 (0.4%)	1 (0.2%)	1.000
Chronic steroid therapy	3,990 (2.2%)	25 (5.1%)	< 0.001
Wound classification			0.009
Clean	175,857 (97.8%)	468 (95.5%)
Clean contaminated	3,399 (1.9%)	16 (3.3%)
Contaminated	589 (0.3%)	5 (1%)
Dirty/infected	38 (0.0%)	1 (0.2%)
Surgical Indication			0.912
Benign	119,986 (66.7%)	328 (66.9%)
Malignant	59,897 (33.3%)	162 (33.1%)
Type of thyroidectomy			0.223
Partial	64,756 (36%)	159 (32.4%)
Total	107,650 (59.8%)	307 (62.7%)
Completion	7,477 (4.2%)	24 (4.9%)
Inpatient/Outpatient status			< 0.001
Outpatient	113,286 (63.0%)	250 (51.0%)
Inpatient	66,597 (37.0%)	240 (49.0%)
Operative time/minutes			0.001
Less than 60	21,405 (11.9%)	54 (11%)
60–90	47,314 (26.3%)	126 (25.7%)
90–120	42,730 (23.8%)	88 (18%)
120–150	28,447 (15.8%)	79 (16.1%)
> 150	39,970 (22.2%)	143 (29.2%)
Missing	17	0
Operative time/minutes*	103.0 (68.0)	111.0 (85.0)	0.003

Abbreviations: ASA, American Society of Anesthesiologists; BMI, body mass index; COPD, chronic obstructive pulmonary disease; UTI, urinary tract infection.

Note: * Reported with median and interquartile range; percentages are presented in columns.

After adjusting for clinically relevant covariates, the multivariable logistic regression analysis identified several risk factors associated with the development of postoperative UTI among thyroidectomy patients. These included age > 60 years (adjusted odd ratio [OR]: 2.187, 95% CI: 1.618–2.956), female gender (OR: 1.767, 95% CI: 1.372–2.278), ASA classifications 3 to 5 (OR: 1.463, 95% CI: 1.185–1.805), partially (OR: 4.267, 95% CI: 2.510–7.253) or totally dependent functional health status (OR: 9.658, 95% CI: 4.170–22.370), pulmonary disease (OR: 1.907, 95% CI: 1.295–2.808), chronic steroid therapy (OR 1.649, 95% CI 1.076–2.527), inpatient procedure (OR: 1.507, 95% CI: 1.251–1.814), and operative time greater than 150 minutes (OR: 1.449, 95% CI: 1.027–2.044) ([Table 3]).

Table 3 Multivariable logistic regression analyses for risk factors of 30-day urinary tract infection

Variable	Adjusted OR	p-value
Age/years
18–40	Reference	–
40–60	1,078 (0.803–1,445)	0.618
> 60	2,187 (1,618–2,956)	< 0.001
Gender
Female	Reference	–
Male	0.566 (0.439–0.729)	< 0.001
BMI (kg/m2)
Healthy (18.5–24.9)	Reference	–
Underweight (< 18.5)	1,892 (0.982–3.645)	0.057
Overweight (25.0–29.9)	1,048 (0.813–1,351)	0.716
Obese (30 or higher)	0.901 (0.704–1,153)	0.408
ASA classification
ASA 1–2	Reference	–
ASA 3–5	1,463 (1,185–1,805)	< 0.001
Functional health status
Independent	Reference	–
Partially independent	4,267 (2,510–7,253)	< 0.001
Totally independent	9,658 (4,170–22,370)	< 0.001
Current smoker	0.851 (0.641–1,129)	0.264
Diabetes mellitus	1,128 (0.881–1,444)	0.339
Pulmonary disease	1,907 (1,295–2,808)	0.001
Cardiovascular disease	1,096 (0.882–1,361)	0.408
Chronic steroid therapy	1,649 (1,076–2,527)	0.022
Wound classification
Clean	Reference	–
Clean contaminated	1,413 (0.840–2,380)	0.193
Contaminated	2,545 (0.941–6,886)	0.066
Dirty/infected	3,677 (0.387–34,976)	0.257
Type of thyroidectomy
Partial	Reference	–
Total	0.964 (0.782–1,187)	0.727
Completion	1,185 (0.769–1,826)	0.441
Inpatient/outpatient status
Outpatient	Reference	–
Inpatient	1,507 (1,251–1,814)	< 0.001
Operative time/minutes
Less than 60	Reference	–
60–90	1,133 (0.816–1,574)	0.455
90–120	0.854 (0.599–1,217)	0.382
120–150	1,114 (0.770–1,612)	0.565
> 150	1,449 (1,027–2,044)	0.035

Abbreviations: ASA, American Society of Anesthesiologists; BMI, body mass index; OR, odds ratio.

Note: Only cases with complete data on all covariates were included (N = 177,847).

Complications

The UTI group was found to have significant associations with various postoperative complications compared with the non-UTI group, including any complication, infectious and non-infectious complications, sepsis, septic shock, pneumonia, unplanned reoperation, CVA/stroke with neurological deficit, prolonged length of stay, mortality, and composites of cardiac, vascular, and pulmonary complications ([Table 4]).

Table 4 Postoperative complications at 30-days, stratified by urinary tract infection status

Outcome	No UTI N = 179,883	UTI N = 490	p-value
Any complication	2,126 (1.2%)	79 (16.1%)	< 0.001
Non-infectious complication	1,015 (0.6%)	37 (7.6%)	< 0.001
CVA/stroke with neurological deficit	48 (0.0%)	3 (0.6%)	< 0.001
Cardiac complications	168 (0.1%)	3 (0.6%)	0.012
Myocardial infarction	95 (0.1%)	3 (0.6%)	0.003
Cardiac arrest requiring CPR	77 (0.0%)	0 (0.0%)	1.000
Pulmonary complications	674 (0.4%)	30 (6.1%)	< 0.001
Ventilator > 48 hours	254 (0.1%)	19 (3.9%)	< 0.001
Unplanned intubation	579 (0.3%)	23 (4.7%)	< 0.001
Renal complications	58 (0.0%)	1 (0.2%)	0.148
Progressive renal insufficiency	35 (0.0%)	0 (0.0%)	1.000
Acute renal failure	23 (0.0%)	1 (0.2%)	0.063
Vascular complications	203 (0.1%)	4 (0.8%)	0.003
Pulmonary embolism	109 (0.1%)	2 (0.4%)	0.037
DVT/thrombophlebitis	109 (0.1%)	2 (0.4%)	0.037
Infectious complications	1,285 (0.7%)	58 (11.8%)	< 0.001
Surgical site infection	848 (0.5%)	5 (1.0%)	0.085
Superficial	632 (0.4%)	3 (0.6%)	0.249
Deep	139 (0.1%)	1 (0.2%)	0.317
Organ/space	84 (0.0%)	1 (0.2%)	0.206
Sepsis	158 (0.1%)	43 (8.8%)	< 0.001
Septic shock	42 (0.0%)	6 (1.2%)	< 0.001
Wound disruption	72 (0.0%)	1 (0.2%)	0.180
Pneumonia	327 (0.2%)	12 (2.4%)	< 0.001
Unplanned reoperation	2,723 (1.5%)	24 (4.9%)	< 0.001
Prolonged length of stay
No	170,756 (95%)	406 (83.4%)	< 0.001
Yes	9,062 (5%)	81 (16.6%)
Missing	65	3
Mortality	97 (0.1%)	2 (0.4%)	0.030

Abbreviations: CPR, cardiopulmonary resuscitation; CVA, cerebrovascular accident; DVT, deep vein thrombosis; UTI, urinary tract infection.

Note: Percentages are presented in columns.

After identifying the significant associations between UTIs and various complications, an adjusted analysis was conducted. The results showed that the occurrence of UTIs was strongly associated with any complication (OR: 12.298, 95% CI: 9.471–15.969), acute renal failure (OR: 9.275, 95% CI: 1.223–70.337), and CVA/stroke with neurological deficit (OR: 11.996, 95% CI: 3.652–39.401). In addition, the occurrence of UTIs was also significantly associated with any pulmonary (OR: 10.281, 95% CI: 6.846–15.440), vascular (OR: 3.702, 95% CI: 1.169–11.724), and cardiac complication (OR: 3.476, 95% CI: 1.094–11.045). Infectious complications (OR: 15.561, 95% CI: 11.617–20.844), sepsis (OR: 84.598, 95% CI: 57.738–123.954), septic shock (OR: 32.902, 95% CI: 13.531–80.006), and pneumonia (OR: 8.616, 95% CI: 4.725–15.714) were also significantly associated with postoperative UTIs. Finally, UTIs were found to be associated with prolonged length of stay (OR: 2.914, 95% CI: 2.202–3.855) and unplanned reoperation (OR: 2.818, 95% CI: 1.856–4.279) as well ([Table 5]).

Table 5 Multivariable logistic regression analyses for different 30-day postoperative complications with urinary tract infection as the main explanatory covariate

Outcome	Adjusted OR	p-value
Any complication	12,298 [9,471–15,969]	< 0.001
Non-infectious complications	8,601 [5,944–12,445]	< 0.001
CVA/stroke with neurological deficit	11,996 [3,652–39,401]	< 0.001
Cardiac complication	3,476 [1,094–11,045]	0.035
Myocardial Infarction	6,569 [2,052–21,025]	0.002
Cardiac arrest requiring CPR	Could not be computed	-
Pulmonary complication	10,281 [6,846–15,440]	< 0.001
Ventilator > 48 hours	14,841 [8,853–24,879]	< 0.001
Unplanned intubation	9,403 [6,014–14,701]	< 0.001
Renal complication	3,537 [0.483–25,914]	0.214
Progressive renal insufficiency	Could not be computed	-
Acute renal failure	9,275 [1,223–70,337]	0.031
Vascular complication	3,702 [1,169–11,724]	0.026
Pulmonary embolism	2,344 [0.324–16,946]	0.399
DVT/thrombophlebitis	4,424 [1,076–18,190]	0.039
Infectious complications	15,561 [11,617–20,844]	< 0.001
Surgical site infection	2,001 [0.824–4,859]	0.125
Superficial	1,667 [0.533–5,213]	0.380
Deep	2,182 [0.302–15,766]	0.439
Organ/space	3,943 [0.542–28,653]	0.175
Sepsis	84,598 [57,738–123,954]	< 0.001
Septic shock	32,902 [13,531–80,006]	< 0.001
Wound disruption	3,850 [0.524–28,265]	0.185
Pneumonia	8,616 [4,725–15,714]	< 0.001
Unplanned reoperation	2,818 [1,856–4,279]	< 0.001
Prolonged length of stay	2,914 [2,202–3,855]	< 0.001
Mortality	3,407 [0.820–14,149]	0.092

Abbreviations: CVA, cerebrovascular accident; DVT, deep vein thrombosis; OR, odds ratio.

Notes: No urinary tract infection was the reference group.

Regression adjusted for age, gender, body mass index, American Society of Anesthesiologists physical status, wound class, operation time, indication, type of thyroidectomy, and inpatient/outpatient surgery.

Only cases with complete data on all covariates and outcomes were included (N = 178,589).

Discussion

To provide a comprehensive understanding of UTIs among thyroidectomy patients, our study investigated the risk factors and outcomes. Our findings identified several significant risk factors, including age > 60 years, female gender, ASA classification 3 to 5, partially or totally dependent functional health status, pulmonary disease, steroid therapy, inpatient procedure, and an operative time > 150 minutes. Notably, our analysis also revealed that the development of UTIs was associated with an increased likelihood of experiencing various complications, such as pulmonary, vascular, or cardiac complication, stroke, acute renal failure, infectious complications, sepsis, septic shock, pneumonia, prolonged length of stay, unplanned reoperation, and mortality. These results underscore the importance of understanding the risk factors associated with UTIs in this patient population and implementing effective control measures to minimize the occurrence of complications.

Our study found advancing age and female gender to be significant demographic risk factors for UTIs following thyroidectomy. These results are consistent with the well-established association between female gender and UTI risk, as adult women are known to be 30 times more likely to develop UTIs than adult males below 50 years of age.[8] It is worth noting that a previous retrospective analysis reported no difference in UTI rates between young, elderly, and supra-elderly age groups following thyroidectomy.[9] However, the prior study did not perform regression analysis specifically for the development of UTIs and reported only univariate differences, which may explain the disparity in results.

Our analysis revealed several surgical risk factors associated with the development of UTIs following thyroidectomy, including ASA classification 3 to 5, inpatient procedure, and an operative time > 150 minutes. The association between ASA class and postoperative morbidity and mortality has been previously validated.[10] Although a recent study reported an association between dependent status and morbidity following thyroidectomy, it did not specifically analyze the regression model for UTIs, instead using a composite outcome that included UTIs along with other complications.[11] Furthermore, inpatient total thyroidectomies are well-known to be associated with a significantly increased risk of UTIs, which could be due to the higher baseline risk of more complex cases considered for inpatient surgery.[2] Another possible explanation is the faster and more frequent diagnosis of UTIs in the inpatient setting. Similarly, a longer operative time is a known independent risk factor for morbidity following multiple surgical procedures.[12] Taken together, our findings provide insight into the surgical risk factors associated with UTIs following thyroidectomy and can inform targeted interventions to reduce the incidence of this complication.

The importance of UTIs as a target for quality improvement initiatives is highlighted by the Centers for Medicare & Medicaid Services (CMS) and Joint Commission.[13] Our findings have clinical relevance as they demonstrate that UTIs are linked to several postoperative complications and mortality. This is consistent with a previous study that found UTIs to be associated with increased risk of postoperative complications and longer hospital stay in patients undergoing head and neck cancer surgery.[14] The inflammatory process that often accompanies UTIs can lead to urosepsis, a condition that carries a high risk of mortality. Additionally, acute kidney injury resulting from UTIs can lead to septic shock.[15] Notably, UTIs have been associated with up to a 3-fold increase in mortality among patients undergoing colorectal cancer surgery.[16] Despite thyroidectomy being a comparatively simple procedure, the risks of morbidity and mortality following UTIs are concerning.

The current study has several implications. First, our findings highlight the need for a better understanding of modifiable risk factors to prevent the development of UTIs and subsequent morbidity. It is crucial to optimize comorbid diseases associated with UTIs preoperatively. Additionally, further investigation is needed to evaluate and implement surgical techniques and equipment that can shorten operative time. As our results indicate that UTIs increase the risk of postoperative complications, patients who are catheterized or susceptible to UTIs should be counseled to remain vigilant for any signs of developing a UTI. However, the impact of catheterization on the development of UTIs could not be explored in this study, as it is not captured in the ACS-NSQIP. Lastly, following the development of UTIs among thyroidectomy patients, it is imperative to provide optimized care to prevent or adequately manage associated complications and improve patient outcomes.

One major strength of our study is the analysis of a large and diverse sample of thyroidectomy patients from a multi-institutional database, which enhances the generalizability of our findings. However, our study has several limitations that must be acknowledged. Notably, the ACS-NSQIP database lacks information on catheterization and its duration, a known risk factor for UTI development in the inpatient setting.[17] Additionally, we could not differentiate the risk of UTIs based on the method of diagnosis due to the lack of relevant data in the ACS-NSQIP. Our results are limited to the 30-day postoperative period, and we cannot make conclusions beyond this time frame. We also acknowledge the possibility of errors in the database as well as the inherent limitations of retrospective studies, which only allow for the establishment of associations rather than causation. Despite these limitations, our study provides valuable insights into the association between UTIs and postoperative complications following thyroidectomy.

Conclusion

Although UTIs may be rare among patients undergoing thyroidectomy, they carry a significant morbidity and mortality burden for this cohort. This study has identified the risk factors and outcomes of UTIs among thyroidectomy patients and recommends preoperative optimization of comorbid diseases and reducing operative times as potential measures to mitigate the risk of UTIs. Overall, this study highlights the importance of addressing and managing UTIs in the context of thyroidectomy, which can potentially improve patient outcomes and reduce the burden of postoperative complications.

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