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Semin Liver Dis 2024; 44(04): 430-456
DOI: 10.1055/s-0044-1791559
Review Article

Therapeutic Potential of Nutraceuticals against Drug-Induced Liver Injury

Namya Sethi
1   Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
,
Manoj Khokhar
1   Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
,
Mitali Mathur
1   Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
,
Yashi Batra
1   Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
,
Amal Mohandas
1   Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
,
Sojit Tomo
1   Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
,
Mahadev Rao
2   Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Karnataka, India
,
Mithu Banerjee
1   Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
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Abstract

Drug-induced liver injury (DILI) continues to be a major concern in clinical practice, thus necessitating a need for novel therapeutic approaches to alleviate its impact on hepatic function. This review investigates the therapeutic potential of nutraceuticals against DILI, focusing on examining the underlying molecular mechanisms and cellular pathways. In preclinical and clinical studies, nutraceuticals, such as silymarin, curcumin, and N-acetylcysteine, have demonstrated remarkable efficacy in attenuating liver injury induced by diverse pharmaceutical agents. The molecular mechanisms underlying these hepatoprotective effects involve modulation of oxidative stress, inflammation, and apoptotic pathways. Furthermore, this review examines cellular routes affected by these nutritional components focusing on their influence on hepatocytes, Kupffer cells, and stellate cells. Key evidence highlights that autophagy modulation as well as unfolded protein response are essential cellular processes through which nutraceuticals exert their cytoprotective functions. In conclusion, nutraceuticals are emerging as promising therapeutic agents for mitigating DILI, by targeting different molecular pathways along with cell processes involved in it concurrently.

Keywords

drug-induced liver injury - polyphenols - terpenes - Nrf-2 - oxidative stress

Authors' Contributions

N.S. conceptualized and wrote the manuscript. M.K. edited the manuscript and prepared the figures and tables. M.M. wrote and edited the manuscript. Y.B. wrote and edited the manuscript. A.M. edited the manuscript. S.T. edited the manuscript. M.R. edited the manuscript. M.B. conceptualized, wrote, and edited the manuscript.




Publikationsverlauf

Artikel online veröffentlicht:
11. Oktober 2024

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