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DOI: 10.1055/s-0045-1805773
Cap polyposis: a rare cause of rectal bleeding in a young woman
Authors
A 35-year-old woman was referred to the Gastroenterology service due to rectal bleeding, anemia, and a palpable rectal mass on physical examination. She had no significant medical history, except for chronic constipation. An ileocolonoscopy was performed, identifying multiple polypoid formations in the mid/distal rectum and anal canal. Histopathological examination revealed inflammatory pseudopolyps, no malignancy, and CMV positivity by immunohistochemistry. Antiviral therapy was administered without improvement of symptoms. The remaining etiological study was negative. The patient experienced clinical deterioration with persistent rectal bleeding and transfusion-dependent anemia. A repeat colonoscopy was then decided for endoscopic polyp removal via mucosectomy and surgery with transanal excision of anal canal lesions. The histology of the rectal lesions was consistent with cap polyposis, and the anal canal lesions were consistent with cloacogenic polyps [1] [2] [3] [4] [5] [6].
Conflicts of interest
Authors do not have any conflict of interest to disclose.
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References
- 1 Saul SH.. Inflammatory cloacogenic polyp: relationship to solitary rectal ulcer syndrome/mucosal prolapse and other bowel disorders. Hum Pathol 1987; 18: 1120-1125
- 2 Tendler DA, Aboudola S, Zacks JF. et al. Prolapsing mucosal polyps: an underrecognized form of colonic polyp – a clinicopathological study of 15 cases. Am J Gastroenterol 2002; 97: 370-376
- 3 Okamoto K, Watanabe T, Komeda Y, Okamoto A, Minaga K, Kamata K, Yamao K, Takenaka M, Hagiwara S, Sakurai T, Tanaka T, Sakamoto H, Fujimoto K, Nishida N, Kudo M.. Dysbiosis-Associated Polyposis of the Colon-Cap Polyposis. Front Immunol 2018; 9: 918
- 4 Oshitani N, Moriyama Y, Matsumoto T, Kobayashi K, Kitano A.. Protein-losing enteropathy from cap polyposis. Lancet 1995; 306: 1567
- 5 Akamatsu T, Nakamura N, Kawamura Y, Shinji A, Tateiwa N, Ochi Y. et al. Possible relationship between Helicobacter pylori infection and cap polyposis of the colon. Helicobacter 2004; 9 (6): 651-6
- 6 Williams GT, Bussey HJ, Morson BC.. Inflammatory “cap” polyps of the large intestine. Br J Surg 1985; 72: S133
Publication History
Article published online:
27 March 2025
© 2025. European Society of Gastrointestinal Endoscopy. All rights reserved.
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References
- 1 Saul SH.. Inflammatory cloacogenic polyp: relationship to solitary rectal ulcer syndrome/mucosal prolapse and other bowel disorders. Hum Pathol 1987; 18: 1120-1125
- 2 Tendler DA, Aboudola S, Zacks JF. et al. Prolapsing mucosal polyps: an underrecognized form of colonic polyp – a clinicopathological study of 15 cases. Am J Gastroenterol 2002; 97: 370-376
- 3 Okamoto K, Watanabe T, Komeda Y, Okamoto A, Minaga K, Kamata K, Yamao K, Takenaka M, Hagiwara S, Sakurai T, Tanaka T, Sakamoto H, Fujimoto K, Nishida N, Kudo M.. Dysbiosis-Associated Polyposis of the Colon-Cap Polyposis. Front Immunol 2018; 9: 918
- 4 Oshitani N, Moriyama Y, Matsumoto T, Kobayashi K, Kitano A.. Protein-losing enteropathy from cap polyposis. Lancet 1995; 306: 1567
- 5 Akamatsu T, Nakamura N, Kawamura Y, Shinji A, Tateiwa N, Ochi Y. et al. Possible relationship between Helicobacter pylori infection and cap polyposis of the colon. Helicobacter 2004; 9 (6): 651-6
- 6 Williams GT, Bussey HJ, Morson BC.. Inflammatory “cap” polyps of the large intestine. Br J Surg 1985; 72: S133