Endoscopy 2025; 57(S 02): S461
DOI: 10.1055/s-0045-1806187
Abstracts | ESGE Days 2025
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Diagnostic Value of Endoscopic Ultrasound-Guided Fine Needle Biopsy in Detecting Diffuse Gastric Carcinoma- A case report

Authors

  • R Mare

    1   Advanced Research Center In Gastroenterology and Hepatology, Victor Babes University of Medicine, Timișoara, Romania

  • S Taban

    2   Morphopathology Division Victor Babes University of Medicine and Pharmacy, Timisoara, Romania

  • D Amadeus

    3   Second Surgery Division Victor Babes University of Medicine and Pharmacy, Timisoara, Romania, Timisoara, Romania

  • R Sirli

    4   Advanced Research Center in Gastroenterology and Hepatology Victor Babes University of Medicine, Timisoara, Romania

  • A Popescu

    5   Advanced Research Center in Gastroenterology and Hepatology Victor Babes University of Medicine, Timișoara, Romania
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Diffuse gastric carcinoma is a rare disease entity, frequently characterized by an early age of onset and a poor prognosis. The aim of this case presentation was to emphasize the role of endoscopic ultrasound guided fine needle biopsy (EUS-FNB) in patients with diffuse gastric carcinoma and negative endoscopic biopsy findings.We present the case of a 47-year-old woman admitted to our hospital with a three-month history of postprandial vomiting, dysphagia related to solid foods, and loss of appetite, resulting in weight loss. Before admission in the hospital she performed several upper endoscopies that revealed a narrow gastric lumen. Repeated conventional biopsies were performed but the histopathological results were negative for malignancy. In the current admission EUS-FNB using a 22-gauge Franseen-tip core biopsy needle was performed. Under EUS guidance we observed a thickened gastric wall of 1.1 cm mainly with a thickened submucosa and muscle layer. EUS-FNB with three passes was performed from the thickened gastric wall. The histopathological examination revealed the presence of poorly cohesive diffuse gastric carcinoma with signet-ring cell G3. The patient was referred to the surgery department were a total gastrectomy followed by esophagojejunostomy with roux-en-Y reconstruction was performed. In conclusion EUS-FNB might contribute to the accurate diagnosis of diffuse gastric carcinoma in cases where standard endoscopic biopsy fails to confirm malignancy.


Conflicts of Interest

Authors do not have any conflict of interest to disclose.

Publication History

Article published online:
27 March 2025

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