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DOI: 10.1055/s-0045-1806847
Original Article

Physicochemical Profile of Yucca filamentosa and a Comparative Chemical Profiling Study of its Mother Tinctures Prepared in and Outside India

Bibaswan Biswas
1   Department of Chemistry, Dr. Anjali Chatterji Regional Research Institute for Homoeopathy, Drug Standardization, Kolkata, West Bengal, India
,
Satyajit Maity
1   Department of Chemistry, Dr. Anjali Chatterji Regional Research Institute for Homoeopathy, Drug Standardization, Kolkata, West Bengal, India
,
Paulami Majumdar
1   Department of Chemistry, Dr. Anjali Chatterji Regional Research Institute for Homoeopathy, Drug Standardization, Kolkata, West Bengal, India
,
Gurudev Choubey 
2   Department of Homoeopathy, Dr. Anjali Chatterjee Regional Research Institute for Homoeopathy, Central Council for Research in Homoeopathy, Ministry of AYUSH, Government of India, Kolkata, West Bengal, India
,
Arti Soren
2   Department of Homoeopathy, Dr. Anjali Chatterjee Regional Research Institute for Homoeopathy, Central Council for Research in Homoeopathy, Ministry of AYUSH, Government of India, Kolkata, West Bengal, India
› Author Affiliations
Funding None.
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Abstract

Introduction

Yucca filamentosa is primarily used in homeopathy for treating gastric ailments, supported by its saponin content. Despite being exotic to India with limited availability, its mother tincture is widely accessible in the country. Given these factors, assessing the quality of these medicines in India is crucial. Therefore, alongside pharmacopeial standardization, a comparative chemical profiling study was conducted on mother tinctures sourced from plants grown in India (OM), those produced in India (IM), and those manufactured abroad (AM).

Materials and Methods

The pharmacopeial parameters of the raw drug, such as loss on drying, different ash values, extractive values in various solvents, and volatile oil content, were measured. Additionally, phytochemical screening of the raw drug in different extractive solvents was performed. Subsequently, the physicochemical parameters including organoleptic characteristics, sediments, total solids, and ultraviolet–visible absorption spectra of OM, IM, and AM were compared. Further comparative phytochemical screening and qualitative high-performance thin-layer chromatography (HPTLC) analysis were conducted.

Results

The pharmacopeial data for the raw drug were reported for the first time. The comparative study on the mother tinctures OM, IM, and AM revealed significant chemical differences.

Conclusion

The comparison of the three mother tinctures (OM, IM, and AM) highlighted substantial chemical variations, underscoring the need for more rigorous chemical and biological evaluations.

Keywords

drug standardization - homeopathy - physicochemical - Yucca filamentosa


Publication History

Article published online:
07 May 2025

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  • References

  • 1 Biswas B, Dey N, Kumar GVN, Arya R, Khurana A. Physicochemical standardisation of the homoeopathic drug Rumex acetosella and its comparison with another homoeopathic drug, Rumex crispus . Indian J Res Homoeopathy 2021; 15: 113-122
    PubMedSearch in Google Scholar
  • 2 Biswas B, Sundaram EN, Jhansi S, Patel S, Khurana A, Manchanda RK. A review on animal-based homoeopathic drugs and their applications in biomedicine. Indian J Res Homoeopathy 2019; 13: 159-176
    PubMedSearch in Google Scholar
  • 3 Tripathy T. Bowel nosodes of homoeopathy in colorectal cancer and auto immune, metabolic, neuro psychiatric disorders. Sch J Appl Med Sci 2023; 11 (09) 1667-1676
    PubMedSearch in Google Scholar
  • 4 Farnsworth NR, Soejarto DD. Global importance of medicinal plants. Conserv Med Plants 1991; 26: 25-51
    PubMedSearch in Google Scholar
  • 5 Cordier C, Morton D, Murrison S, Nelson A, O'Leary-Steele C. Natural products as an inspiration in the diversity-oriented synthesis of bioactive compound libraries. Nat Prod Rep 2008; 25 (04) 719-737
    PubMedSearch in Google Scholar
  • 6 Silveira D, Prieto JM, Freitas MM, Mazzari ALDA. Herbal medicine and public healthcare: current and future challenges. In: Cechinel Filho V. eds. Natural Products as Source of Molecules with Therapeutic Potential. Cham: Springer; 2018: 495-515
    Search in Google Scholar
  • 7 World Health Organization. Guidelines for the Assessment of Herbal Medicines. Geneva: World Health Organization; 1991
    Search in Google Scholar
  • 8 World Health Organization. Research Guidelines for Evaluating the Safety and Efficacy of Herbal Medicines. Manila: WHO Regional Office for the Western Pacific; 1993
    Search in Google Scholar
  • 9 Massey L, Hamrick J. Genetic diversity and population structure of Yucca filamentosa (Agavaceae). Am J Bot 1998; 85 (03) 340-345
    PubMedSearch in Google Scholar
  • 10 Kew Science. Yucca filamentosa L. | Plants of the World Online. Accessed July 4, 2024 at: https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:325008-2
    PubMed
  • 11 Boericke W. Yucca filamentosa. In: Homoeopathic Materia Medica. Accessed July 4, 2024 at: http://homeoint.org/books/boericmm/y/yuc.htm
    PubMed
  • 12 Hamed M, El-Amin S, Abdel-Fattah AS. Isolation and identification of some compounds from molluscicidaly active plant Yucca filamentosa “Marginata.”. Pharmacologyonline 2015; 1: 19-30
    PubMedSearch in Google Scholar
  • 13 Dragalin IP, Gulya AP, Krokhmalyuk VV, Kintya PK. The structure of yuccoside E from Yucca filamentosa . Chem Nat Compd 1975; 11: 772-774
    PubMedSearch in Google Scholar
  • 14 Salaheldin Abdelhamid Ibrahim S, Bassam SM, El-Hawary S. et al. The gastroprotective effect of Yucca filamentosa standardized crude leaves extract versus its nano-cubosomal formulation in ethanol-induced gastric injury. Int Immunopharmacol 2024; 137: 112440
    PubMedSearch in Google Scholar
  • 15 Shi Z, Long X, Li Y. et al. Protective effect of tea saponins on alcohol-induced gastric mucosal injury in mice. ACS Omega 2022; 8 (01) 673-681
    PubMedSearch in Google Scholar
  • 16 eFlora of India. Yucca filamentosa (cultivated). Accessed July 4, 2024 at: https://efloraofindia.com/2018/08/14/yucca-filamentosa/
    PubMed
  • 17 Liu Y, Chen P, Zhou M. et al. Geographic variation in the chemical composition and antioxidant properties of phenolic compounds from Cyclocarya paliurus (Batal) Iljinskaja leaves. Molecules 2018; 23 (10) 2440
    PubMedSearch in Google Scholar
  • 18 Konieczynski P, Viapiana A, Lysiuk R, Wesolowski M. Chemical composition of selected commercial herbal remedies in relation to geographical origin and inter-species diversity. Biol Trace Elem Res 2018; 182 (01) 169-177
    PubMedSearch in Google Scholar
  • 19 Ministry of Health and Family Welfare. Yucca filmentosa monograph. In: Homoeopathic Pharmacopoeia of India (HPI). Combined Vol. I to V (Revised and Augmented). New Delhi: Ministry of Health and Family Welfare; 2016: 1281
    Search in Google Scholar
  • 20 Caws AC, Foster GE. The purity of chloroform B. P. J Pharm Pharmacol 1957; 9 (12) 824-832 , discussion 832–833
    PubMedSearch in Google Scholar
  • 21 Biswas B, Maity S, Bhar K, Sett S, Narasimha Kumar GV. Physicochemical study, chemical profiling and molecular docking study for standardisation of the homoeopathic drug Damiana. HPL 2023; 36 (03) 180-190
    PubMedSearch in Google Scholar
  • 22 Ministry of Health and Family Welfare. Powders and Sieves: Appendix-XIII. In: Homoeopathic Pharmacopoeia of India (HPI). Combined Vol. I to V (Revised and Augmented). New Delhi: Ministry of Health and Family Welfare; 2016: 381
    Search in Google Scholar
  • 23 Ministry of Health & Family Welfare. B. Percolation: general instructions. In: Homoeopathic Pharmacopoeia of India (HPI). Combined Vol. I TO V (Revised & Augmented)). New Delhi: Ministry of Health & Family Welfare; 2016: 39
    Search in Google Scholar
  • 24 Pharmacopoeia Commission for Indian Medicine & Homoeopathy. Determination of total ash. Appendix – 2. In: Ayurvedic Pharmacopoeia of India. 1st ed.. Vol. 9. Part 1. Ghaziabad: PCIMH; 2016: 113
    Search in Google Scholar
  • 25 Patel S, Biswas B, Rambabu K. et al. Pharmacognostic and physicochemical study of Urtica urens L.: a drug used in homoeopathy. Indian J Res Homoeopathy 2019; 13: 91-99
    CrossrefPubMedSearch in Google Scholar
  • 26 Deshmukh MA, Theng MA. Phytochemical screening, quantitative analysis of primary and secondary metabolites of Acacia arabica bark. Int J Curr Pharm Res 2018; 10: 35-37
    CrossrefPubMedSearch in Google Scholar
  • 27 Baba SA, Malik SA. Determination of total phenolic and flavonoid content, antimicrobial and antioxidant activity of a root extract of Arisaema jacquemontii Blume. J Taibah Univ Sci 2015; 9: 449-454
    CrossrefPubMedSearch in Google Scholar
  • 28 Van Tan P. The determination of total alkaloid, polyphenol, flavonoid and saponin contents of Pogang gan (Curcuma sp.). Int J Biol 2018; 10: 42-47
    PubMedSearch in Google Scholar