Subscribe to RSS
DOI: 10.1055/s-0045-1809652
Optimizing Free Functioning Muscle Transfer for Lower Limb Reconstruction: A Biomechanical Approach
Funding None.

Abstract
Free functioning muscle transfer (FFMT) is widely used to reconstruct complex lower limb defects involving muscle deficits. This review explores ways to optimize FFMT outcomes by examining biomechanical considerations, particularly balancing the needs for stable joint positioning (isometric function) and active motion (isotonic function) for specific reconstructive objectives. We discuss knee extension, ankle dorsiflexion, and ankle plantarflexion reconstruction, recommending suitable donor muscles based on their mechanical properties and functional requirements. Important considerations include careful donor muscle selection, accurate muscle tensioning during surgery, secure tendon attachment methods, and targeted rehabilitation timed with nerve recovery. This approach offers practical advice for surgeons aiming to restore movement and improve overall function in patients undergoing complex lower limb reconstructions.
Keywords
free functioning muscle transfer - lower extremity reconstruction - functional outcomes - donor muscle selectionPublication History
Article published online:
08 August 2025
© 2025. Thieme. All rights reserved.
Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA
-
References
- 1 Tamai S, Komatsu S, Sakamoto H, Sano S, Sasauchi N. Free muscle transplants in dogs, with microsurgical neurovascular anastomoses. Plast Reconstr Surg 1970; 46 (03) 219-225
- 2 Doi K, Kuwata N, Kawakami F, Hattori Y, Otsuka K, Ihara K. Limb-sparing surgery with reinnervated free-muscle transfer following radical excision of soft-tissue sarcoma in the extremity. Plast Reconstr Surg 1999; 104 (06) 1679-1687
- 3 Lin CH, Lin YT, Yeh JT, Chen CT. Free functioning muscle transfer for lower extremity posttraumatic composite structure and functional defect. Plast Reconstr Surg 2007; 119 (07) 2118-2126
- 4 Chi D, Raman S, Tawaklna K. et al. Free functional muscle transfer for lower extremity reconstruction. J Plast Reconstr Aesthet Surg 2023; 86: 288-299
- 5 Ober FR. Tendon transplantation in the lower extremity. N Engl J Med 1933; 209 (02) 52-59
- 6 Fischer S, Soimaru S, Hirsch T. et al. Local tendon transfer for knee extensor mechanism reconstruction after soft tissue sarcoma resection. J Plast Reconstr Aesthet Surg 2015; 68 (05) 729-735
- 7 Lieber RL, Fridén J. Functional and clinical significance of skeletal muscle architecture. Muscle Nerve 2000; 23 (11) 1647-1666
- 8 Lieber RL, Fridén J. Clinical significance of skeletal muscle architecture. Clin Orthop Relat Res 2001; (383) 140-151
- 9 Manktelow RT, McKee NH. Free muscle transplantation to provide active finger flexion. J Hand Surg Am 1978; 3 (05) 416-426
- 10 Mathes SJ, Nahai F. Classification of the vascular anatomy of muscles: experimental and clinical correlation. Plast Reconstr Surg 1981; 67 (02) 177-187
- 11 Markhede G, Stener B. Function after removal of various hip and thigh muscles for extirpation of tumors. Acta Orthop Scand 1981; 52 (04) 373-395
- 12 Muramatsu K, Ihara K, Miyoshi T, Yoshida K, Hashimoto T, Taguchi T. Transfer of latissimus dorsi muscle for the functional reconstruction of quadriceps femoris muscle following oncological resection of sarcoma in the thigh. J Plast Reconstr Aesthet Surg 2011; 64 (08) 1068-1074
- 13 Innocenti M, Abed YY, Beltrami G, Delcroix L, Balatri A, Capanna R. Quadriceps muscle reconstruction with free functioning latissimus dorsi muscle flap after oncological resection. Microsurgery 2009; 29 (03) 189-198
- 14 Walley KC, Taylor EM, Anderson M, Lozano-Calderon S, Iorio ML. Reconstruction of quadriceps function with composite free tissue transfers following sarcoma resection. J Surg Oncol 2017; 115 (07) 878-882
- 15 Doi K, Sakai K, Ihara K, Abe Y, Kawai S, Kurafuji Y. Reinnervated free muscle transplantation for extremity reconstruction. Plast Reconstr Surg 1993; 91 (05) 872-883
- 16 Grinsell D, Lonie S, Wilson KC, Choong PFM. The innervated rectus abdominis flap for quadriceps reconstruction. J Plast Reconstr Aesthet Surg 2019; 72 (06) 941-945
- 17 Yeap JS, Singh D, Birch R. A method for evaluating the results of tendon transfers for foot drop. Clin Orthop Relat Res 2001; (383) 208-213
- 18 Begg RK, Sparrow WA. Ageing effects on knee and ankle joint angles at key events and phases of the gait cycle. J Med Eng Technol 2006; 30 (06) 382-389
- 19 Moosabhoy MA, Gard SA. Methodology for determining the sensitivity of swing leg toe clearance and leg length to swing leg joint angles during gait. Gait Posture 2006; 24 (04) 493-501
- 20 Winter DA. Foot trajectory in human gait: a precise and multifactorial motor control task. Phys Ther 1992; 72 (01) 45-53 , discussion 54–56
- 21 Ninković M. Neuromusculotendinous transfer: an original surgical concept for the treatment of drop foot with long-term follow-up. Plast Reconstr Surg 2013; 132 (03) 438e-445e
- 22 Ninković M, Sućur D, Starović B, Marković S. A new approach to persistent traumatic peroneal nerve palsy. Br J Plast Surg 1994; 47 (03) 185-189
- 23 O'Brien BM, Morrison WA, MacLeod AM, Weiglein O. Free microneurovascular muscle transfer in limbs to provide motor power. Ann Plast Surg 1982; 9 (05) 381-391
- 24 Kobayashi S, Sekiguchi J, Sakai Y, Ohmori K. Functioning free muscle transplantation to the lower leg. J Reconstr Microsurg 1995; 11 (05) 319-325
- 25 Botte MJ, Santi MD, Prestianni CA, Abrams RA. Ischemic contracture of the foot and ankle: principles of management and prevention. Orthopedics 1996; 19 (03) 235-244
- 26 Moschella F, D'Arpa S, Pirrello R, Cordova A. Posterior compartment of the lower leg reconstruction with free functional rectus femoris transfer after sarcoma resection. J Plast Reconstr Aesthet Surg 2010; 63 (03) e269-e272
- 27 Rednam RS, Rinker BD. Reconstruction of posterior compartment of lower extremity using a functional latissimus dorsi free flap: A case report. Microsurgery 2016; 36 (01) 77-80
- 28 Lin CH, Wei FC, Lin YT, Yeh JT, Rodriguez EdeJ, Chen CT. Lateral circumflex femoral artery system: warehouse for functional composite free-tissue reconstruction of the lower leg. J Trauma 2006; 60 (05) 1032-1036