Zentralbl Chir 2025; 150(S 01): S74
DOI: 10.1055/s-0045-1809720
Abstracts
Onkologische Thoraxchirurgie

How should Primary Pulmonary Sarcoma be staged? Results of an International Multicenter Database

Authors

  • T Stork

    1   Kliniken Köln Merheim, Lungenklinik – Thoraxchirurgie, Köln, Deutschland

  • D Adamkova

    2   Masaryk University, Brno, Tschechische Republik

  • C Aigner

    3   Medizinische Universität Wien, Wien, Österreich

  • I Bravio

    4   Francisco Gentil Portuguese Institute of Oncology CUF Infante Santo Hospital, Lisboa, Portugal

  • A Brunello

    5   Università degli Studi di Padova, Padova, Italien

  • L Cerbone

    6   University of Genoa, Genoa, Italien

  • H Clermidy

    7   Louis Pradel Hospital, Lyon, Frankreich

  • L De Cock

    8   Leuven Cancer Institute, Leuven, Belgien

  • S Gasperoni

    9   University Hospital Careggi, Firenze, Italien

  • N Girard

    10   Institut Curie, Paris, Frankreich

  • A Mariuk-Jarema

    11   Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Polen

  • R Lefering

    12   Institute for Research in Operative Medicine (IFOM), University Witten/Herdecke, Köln, Deutschland

  • E Melis

    13   IRCCS National Cancer Institute Regina Elena, Rome, Italien

  • G Marquina

    14   EURACAN Referral Centre, Universidad Complotense de Madrid (UCM), Madrid, Spanien

  • F Mazzeo

    15   Université Catholique de Louvain, Brussels, Belgien

  • I Mykoliuk

    16   Medical University of Graz, Graz, Österreich

  • N Penel

    17   Centre Oscar Lambret, University of Lille, Lille, Frankreich

  • H-U Schildhaus

    18   Discovery Life Sciences Biomarker GmbH und Pathologie Nordhessen, Kassel, Deutschland

  • S Strippoli

    19   IRCCS Istituto Tumori Giovanni Paolo II Bari, Bari, Italien

  • B Vincenzi

    20   Università Campus Bio-Medico di Roma, Roma, Italien

  • S Watson

    10   Institut Curie, Paris, Frankreich

  • J-Y Blay

    21   Centre Léon Bérard, Lyon, Frankreich

  • S Bauer

    22   University Hospital Essen, Essen, Deutschland

  • S Collaud

    1   Kliniken Köln Merheim, Lungenklinik – Thoraxchirurgie, Köln, Deutschland
Further Information
Also available at
 
 

    Background Primary pulmonary sarcomas (PPS) are very rare, accounting for only 1% of all pulmonary malignancies. No dedicated staging system for PPS is available. We tested the value of both lung cancer and soft tissue sarcoma staging systems for PPS.

    Methods & Materials We created an international multicenter database of patients with PPS through a network of sarcoma expert centers. Data on demographics, staging, multimodality treatment including surgery, and outcomes were retrieved. Patients were staged according to TNM for lung cancer (8th edition) and AJCC Staging for Trunk and Extremity Soft Tissue Sarcomas (STS). Overall survivals were compared.

    Results 173 patients with PPS from 18 centers from nine European countries were included. 114 patients (66%) underwent curative-intent surgery within multimodality treatment. Extent of lung resection was sublobar (n=11, 10%), lobar (n=58, 50%), or bilobar/pneumonectomy (n=39, 34%). Median tumor size was 83 mm. 69 patients had grade 3 tumors (72%). R0 resection was achieved in 85 patients (74%). Seventy patients underwent lymphadenectomy (63%). Eleven patients had nodal involvement (16%). Overall survival was 49% and 31% at five and ten years, respectively. Median follow-up was 33 months. According to TNM for lung cancer, 15 (13%) patients had stage I, 15 (13%) had stage II, 45 (40%) had stage III and 22 (19%) had stage 4. 5-year OS were 90%, 55%, 48% and 22%, respectively (p=0.001). According to AJCC staging for Trunk and Extremity STS (including tumor size, grading, nodal status and metastases), 2 (2%) patients had stage I, 19 (17%) had stage II, 37 (32%) had stage III and 29 (25%) had stage IV. 5-years OS were 100%, 74%, 50% and 24%, respectively (p=0.005).

    Conclusion In our cohort of patient with curative-intent surgery, AJCC staging for Trunk and Extremity STS is more reliable than lung cancer staging system.


     

    Publication History

    Article published online:
    25 August 2025

    © 2025. Thieme. All rights reserved.

    Georg Thieme Verlag KG
    Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany