Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000068.xml
Download PDF
Semin intervent Radiol
DOI: 10.1055/s-0045-1810075
DOI: 10.1055/s-0045-1810075
Review Article
Percutaneous Management of Benign Bone Cysts and Tumors in Children
Funding None.
Abstract
Curettage with grafting and open surgical resection used to be the mainstay for treating bone cysts and benign bone tumors in children; however, given the morbidity and high recurrence rates associated with open surgical techniques, minimally invasive approaches have become primary therapy in many clinical instances, which the field of interventional radiology is pioneering. This manuscript specifically addresses minimally invasive, percutaneous interventions for unicameral bone cysts, aneurysmal bone cysts, osteoid osteoma, and chondroblastoma in children.
Publication History
Article published online:
11 July 2025
© 2025. Thieme. All rights reserved.
Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA
-
References
- 1 Rosenblatt J, Koder A. Understanding unicameral and aneurysmal bone cysts. Pediatr Rev 2019; 40 (02) 51-59
- 2 Schreuder HW, Veth RP, Pruszczynski M, Lemmens JA, Koops HS, Molenaar WM. Aneurysmal bone cysts treated by curettage, cryotherapy and bone grafting. J Bone Joint Surg Br 1997; 79 (01) 20-25
- 3 Mahnken AH, Nolte-Ernsting CCA, Wildberger JE. et al. Aneurysmal bone cyst: value of MR imaging and conventional radiography. Eur Radiol 2003; 13 (05) 1118-1124
- 4 Restrepo R, Zahrah D, Pelaez L, Temple HT, Murakami JW. Update on aneurysmal bone cyst: pathophysiology, histology, imaging and treatment. Pediatr Radiol 2022; 52 (09) 1601-1614
- 5 Oliveira AM, Perez-Atayde AR, Dal Cin P. et al. Aneurysmal bone cyst variant translocations upregulate USP6 transcription by promoter swapping with the ZNF9, COL1A1, TRAP150, and OMD genes. Oncogene 2005; 24 (21) 3419-3426
- 6 Gaelen JI, Wu C, Yang A. et al. Use of regional anesthesia within a pediatric interventional radiology suite reduced periprocedural opioid use without delaying the overall workflow: a retrospective study. Reg Anesth Pain Med 2024;
- 7 Rajeswaran S, Wiese M, Baker J. et al. Treatment of unicameral bone cysts utilizing the sclerograft technique. Cardiovasc Intervent Radiol 2024; 47 (03) 346-353
- 8 Zhao JG, Wang J, Huang WJ, Zhang P, Ding N, Shang J. Interventions for treating simple bone cysts in the long bones of children. Cochrane Database Syst Rev 2017; 2 (02) CD010847
- 9 Hagmann S, Eichhorn F, Moradi B. et al. Mid- and long-term clinical results of surgical therapy in unicameral bone cysts. BMC Musculoskelet Disord 2011; 12: 281
- 10 Donaldson S, Wright JG. Simple bone cysts: better with age?. J Pediatr Orthop 2015; 35 (01) 108-114
- 11 Rajeswaran S, Khan A, Samet JD. et al. Minimally invasive treatment for unicameral bone cysts with chemical sclerosis and bone graft substitute: a preliminary report. Cardiovasc Intervent Radiol 2022; 45 (02) 190-196
- 12 Wong MN, Begley KA, Braswell LE. et al. Doxycycline sclerotherapy of aneurysmal and unicameral bone cysts in the appendicular skeleton and pelvis: single-center 14-year experience. J Vasc Interv Radiol 2024; 35 (12) 1785-1792.e5
- 13 Gentile JV, Weinert CR, Schlechter JA. Treatment of unicameral bone cysts in pediatric patients with an injectable regenerative graft: a preliminary report. J Pediatr Orthop 2013; 33 (03) 254-261
- 14 Park HY, Yang SK, Sheppard WL. et al. Current management of aneurysmal bone cysts. Curr Rev Musculoskelet Med 2016; 9 (04) 435-444
- 15 Cottalorda J, Bourelle S. Current treatments of primary aneurysmal bone cysts. J Pediatr Orthop B 2006; 15 (03) 155-167
- 16 Rossi G, Rimondi E, Bartalena T. et al. Selective arterial embolization of 36 aneurysmal bone cysts of the skeleton with N-2-butyl cyanoacrylate. Skeletal Radiol 2010; 39 (02) 161-167
- 17 Masthoff M, Gerwing M, Schneider KN. et al. Combined transarterial embolization and percutaneous sclerotherapy as treatment for refractory and nonresectable aneurysmal bone cysts. J Vasc Interv Radiol 2021; 32 (10) 1425-1434.e2
- 18 Dubois J, Chigot V, Grimard G, Isler M, Garel L. Sclerotherapy in aneurysmal bone cysts in children: a review of 17 cases. Pediatr Radiol 2003; 33 (06) 365-372
- 19 Shiels II WE, Mayerson JL. Percutaneous doxycycline treatment of aneurysmal bone cysts with low recurrence rate: a preliminary report. Clin Orthop Relat Res 2013; 471 (08) 2675-2683
- 20 Varshney MK, Rastogi S, Khan SA, Trikha V. Is sclerotherapy better than intralesional excision for treating aneurysmal bone cysts?. Clin Orthop Relat Res 2010; 468 (06) 1649-1659
- 21 Arleo TL, Hawkins CM, Fabregas JA, Gill AE. Percutaneous image-guided treatment of aneurysmal bone cysts: is there a superior treatment option?. Pediatr Radiol 2022; 52 (08) 1539-1549
- 22 Serrano E, Zarco F, Gill AE. et al. Percutaneous cryoablation of chondroblastoma and osteoblastoma in pediatric patients. Insights Imaging 2021; 12 (01) 106
- 23 Maximen J, Robin F, Tronchot A, Rossetti A, Ropars M, Guggenbuhl P. Denosumab in the management of aneurysmal bone cyst. Joint Bone Spine 2022; 89 (01) 105260
- 24 Hage AN, Chick JFB, Gemmete JJ, Grove JJ, Srinivasa RN. Percutaneous radiofrequency ablation for the treatment of osteoid osteoma in children and adults: a comparative analysis in 92 patients. Cardiovasc Intervent Radiol 2018; 41 (09) 1384-1390
- 25 Lindquester WS, Crowley J, Hawkins CM. Percutaneous thermal ablation for treatment of osteoid osteoma: a systematic review and analysis. Skeletal Radiol 2020; 49 (09) 1403-1411
- 26 Whitmore MJ, Hawkins CM, Prologo JD. et al. Cryoablation of osteoid osteoma in the pediatric and adolescent population. J Vasc Interv Radiol 2016; 27 (02) 232-237 , quiz 238
- 27 Rinzler ES, Shivaram GM, Shaw DW, Monroe EJ, Koo KSH. Microwave ablation of osteoid osteoma: initial experience and efficacy. Pediatr Radiol 2019; 49 (04) 566-570
- 28 Reis J, Chang Y, Sharma AK. Radiofrequency ablation vs microwave ablation for osteoid osteomas: long-term results. Skeletal Radiol 2020; 49 (12) 1995-2000
- 29 Somma F, Stoia V, D'Angelo R, Fiore F. Imaging-guided radiofrequency ablation of osteoid osteoma in typical and atypical sites: long term follow up. PLoS One 2021; 16 (03) e0248589
- 30 Sangiorgio A, Oldrini LM, Candrian C, Errani C, Filardo G. Radiofrequency ablation is as safe and effective as surgical excision for spinal osteoid osteoma: a systematic review and meta-analysis. Eur Spine J 2023; 32 (01) 210-220
- 31 Prologo JD, Johnson C, Hawkins CM. et al. Natural history of mixed and motor nerve cryoablation in humans-a cohort analysis. J Vasc Interv Radiol 2020; 31 (06) 912-916.e1
- 32 Aarts BM, Klompenhouwer EG, Rice SL. et al. Cryoablation and immunotherapy: an overview of evidence on its synergy. Insights Imaging 2019; 10 (01) 53
- 33 Chen Z, Meng L, Zhang J, Zhang X. Progress in the cryoablation and cryoimmunotherapy for tumor. Front Immunol 2023; 14: 1094009
- 34 Kurup AN, Morris JM, Boon AJ. et al. Motor evoked potential monitoring during cryoablation of musculoskeletal tumors. J Vasc Interv Radiol 2014; 25 (11) 1657-1664
- 35 Vikingstad EM, de Ridder GG, Glisson RR. et al. Comparison of acute histologic and biomechanical effects of radiofrequency ablation and cryoablation on periarticular structures in a swine model. J Vasc Interv Radiol 2015; 26 (08) 1221-1228.e1
- 36 Carneiro BC, Da Cruz IAN, Ormond Filho AG. et al. Osteoid osteoma: the great mimicker. Insights Imaging 2021; 12 (01) 32
- 37 Kulkarni SS, Shetty NS, Gala KB. et al. Percutaneous radiofrequency ablation of appendicular skeleton chondroblastoma-an experience from a tertiary care cancer center. J Vasc Interv Radiol 2021; 32 (04) 504-509
- 38 Ruiz SF, Láinez R-BAJ, Martínez MA, García EJ. Chondroblastoma treatment by radiofrequency thermal ablation: initial experience and implementation. Eur J Radiol 2021; 144: 109950
- 39 Rybak LD, Rosenthal DI, Wittig JC. Chondroblastoma: radiofrequency ablation–alternative to surgical resection in selected cases. Radiology 2009; 251 (02) 599-604
- 40 Huang C, Lü X-M, Fu G, Yang Z. Chondroblastoma in the children treated with intralesional curettage and bone grafting: outcomes and risk factors for local recurrence. Orthop Surg 2021; 13 (07) 2102-2110
- 41 Tosyalı HK, Kaya H, Kececi B, Sabah D. Management of chondroblastoma in pediatric patients: 21 years of single-center experience. Children (Basel) 2024; 11 (06) 672
- 42 Focaccia M, Gambarotti M, Hakim R. et al. Chondroblastoma's lung metastases treated with denosumab in pediatric patient. Cancer Res Treat 2021; 53 (01) 279-282
- 43 Arkader A, Williams A, Binitie O, Thacker MM, Farfalli GL. Pediatric chondroblastoma and the need for lung staging at presentation. J Pediatr Orthop 2020; 40 (09) e894-e897