Influence of Low-Flow Oxygen Supply on Sleep Architecture in Patients with Severe Heart Failure (NYHA III-IV) and Cheyne-Stokes Respiration

Stefan A. Thalhofer; Peter Dorow; Philipp Meissner

doi:10.1055/s-2000-11568

Sleep and Breathing, Table of Contents

Sleep Breath 2000; 04(3): 113-120
DOI: 10.1055/s-2000-11568

Influence of Low-Flow Oxygen Supply on Sleep Architecture in Patients with Severe Heart Failure (NYHA III-IV) and Cheyne-Stokes Respiration

Stefan A. Thalhofer, Peter Dorow, Philipp Meissner

DRK-Klininiken Mark Brandenburg, Department of Respiratory and Intensive Care Medicine, Berlin, Germany

Abstract

ABSTRACT

Patients suffering from severe heart failure may develop breathing pattern disorders during sleep, especially in the form of Cheyne-Stokes respiration. Results may be severe disturbances in sleep architecture and worsening of hemodynamics and of prognosis of these patients. Causes of the periodic breathing disorders are probably hypocapnia, hypersensitivity of respiratory control centers, hypoxemia, and prolonged blood circulation time. This study examined the influence of different concentrations of continously administered oxygen during the nighttime on breathing pattern disorders, oxygen saturation, and sleep architecture in 65 patients with severe heart failure (NYHA III-IV). Fifty-two of 65 patients showed an improvement of sleep architecture. Total sleeping time increased significantly (p < 0.01). Fragmentations of sleep by arousals decreased ( p < 0.01); time of random eye movement (REM) sleep and non-REM sleep III and IV increased significantly.

KEYWORD

Cheyne-Stokes respiration - dilated cardiomyopathy - congestive heart failure - oxygen supply - sleep architecture

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