Inflammatory Bowel Disease

This article reviews important papers on inflammatory bowel disease published between May 1998 and June 1999. It does not review every aspect of treatment, but focuses on the effects of anti-tumor necrosis factor antibodies on the inflammatory lesions. The new information summarized includes: the role of bacteria and the modulating effects of probiotics; the frequency of appendiceal orifice inflammation in ulcerative colitis; progress in imaging based on endoscopic ultrasonography, magnetic resonance imaging, and leukocyte scintigraphy; frequency and treatment of massive hemorrhage, viral superinfection, and persistent perineal sinus; and the pathogenesis, detection, and treatment of dysplasia and cancer.

References (Key References are highlighted)

• 1 Schölmerich J. Inflammatory bowel disease.  Endoscopy. 1999;  31 66-73
• 2 Hugot  JP, Zouali H, Lesage S, Thomas G. Etiology of the inflammatory bowel diseases.  Int J Colorectal Dis. 1999;  14 2-9
• 3 Darfeuille-Michaud A, Neut C, Barnich N, et al. Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease.  Gastroenterology. 1998;  115 1405-1413
• 4 Walmsley RS, Anthony A, Sim R, et al. Absence of Escherichia coli, Listeria monocytogenes, and Klebsiella pneumoniae antigens within inflammatory bowel disease tissues.  J Clin Pathol. 1998;  51 657-661
• 5 Tiveljung A, Soderholm JD, Olaison G, et al. Presence of eubacteria in biopsies from Crohn's disease inflammatory lesions as determined by 16S rRNA gene-based PCR.  J Med Microbiol. 1999;  48 263-268
• 6 Madsen KL, Doyle JS, Jewell LD, et al. Lactobacillus species prevent colitis in interleukin 10 gene-deficient mice.  Gastroenterology. 1999;  116 1107-1114
• 7 Campieri  M, Gionchetti P. Probiotics in inflammatory bowel disease: new insight to pathogenesis or a possible therapeutic alternative?.  Gastroenterology. 1999;  116 1246-1249
• 8 Okawa K, Aoki T, Sano K, et al. Ulcerative colitis with skip lesions at the mouth of the appendix: a clinical study.  Am J Gastroenterol. 1998;  93 2405-2410
• 9 Yang SK, Jung HY, Kang GH, et al. Appendiceal orifice inflammation as a skip lesion in ulcerative colitis: an analysis in relation to medical therapy and disease extent.  Gastrointest Endosc. 1999;  49 743-747
• 10 Tribl B, Turetschek K, Mostbeck G, et al. Conflicting results of ileoscopy and small bowel double-contrast barium examination in patients with Crohn's disease.  Endoscopy. 1998;  30 339-344
• 11 Tsang  P, Rotterdam H. Biopsy diagnosis of colitis: possibilities and pitfalls.  Am J Surg Pathol. 1999;  23 423-430
• 12 Dagli U, Over H, Tezel A, et al. Transrectal ultrasound in the diagnosis and management of inflammatory bowel disease.  Endoscopy. 1999;  31 152-157
• 13 Gast  P, Belaïche J. Rectal endosonography in inflammatory bowel disease: differential diagnosis and prediction of remission.  Endoscopy. 1999;  31 158-166
• 14 Gast P. Endorectal ultrasound in infectious colitis may predict development of chronic colitis.  Endoscopy. 1999;  31 265-268
• 15 Tsuga K, Haruma K, Fujimura J, et al. Evaluation of the colorectal wall in normal subjects and patients with ulcerative colitis using an ultrasonic catheter probe.  Gastrointest Endosc. 1998;  48 477-484
• 16 Soweid AM, Chak A, Katz JA, et al. Catheter probe-assisted endoluminal US in inflammatory bowel disease.  Gastrointest Endosc. 1999;  50 41-46
• 17 Orsoni P, Barthet M, Portier F, et al. Prospective comparison of endosonography, magnetic resonance imaging and surgical findings in anorectal fistula and abscess complicating Crohn's disease.  Br J Surg. 1999;  86 360-364
• 18 Madsen SM, Thomsen HS, Munkholm P, et al. Active Crohn's disease and ulcerative colitis evaluated by low-field magnetic resonance imaging.  Scand J Gastroenterol. 1998;  33 1193-1200
• 19 Guimbaud  R, Beades E, Chauvelot-Moachon L, et al. Technetium Tc-99m hexamethyl propylene amine oxine leukocyte scintigraphy in patients with ulcerative colitis: correlation with clinical, biologic, endoscopic, and pathologic intensity, and local release of interleukin 8.  Gastrointest Endosc. 1998;  48 491-496
• 20 Aburano T, Saito Y, Shuke N, et al. Tc-99m leukocyte imaging for evaluating disease severity and monitoring treatment response in ulcerative colitis: comparison with colonoscopy.  Clin Nucl Med. 1998;  23 509-513
• 21 Sans M, Llach J, Bordas JM, et al. Life-threatening hemorrhage: an unusual form of presentation of Crohn's disease treated with endoscopic injection sclerotherapy.  Endoscopy. 1998;  30 S83-S84
• 22 Pardi DS, Loftus EV Jr, Tremaine WJ, et al. Acute major gastrointestinal hemorrhage in inflammatory bowel disease.  Gastrointest Endosc. 1999;  49 153-157
• 23 Dijkstra B, Bagshaw PF, Frizelle FA. Protective effect of appendectomy on the development of ulcerative colitis: matched, case-control study.  Dis Colon Rectum. 1999;  42 334-336
• 24 Moum B, Ekbom A, Vatn MH, Elgjo K. Change in the extent of colonoscopic and histological involvement in ulcerative colitis over time.  Am J Gastroenterol. 1999;  94 1564-1569
• 25 Yamamoto T, Bain IM, Allan RN, Keighley MR. Persistent perineal sinus after proctocolectomy for Crohn's disease.  Dis Colon Rectum. 1999;  42 96-101
• 26 Yamamoto  T, Keighley RB. Long-term outcome of total colectomy and ileostomy for Crohn disease.  Scand J Gastroenterol. 1999;  34 280-286
• 27 Lautenbach E, Berlin JA, Lichtenstein GR. Risk factors for early postoperative recurrence of Crohn's disease.  Gastroenterology. 1998;  115 259-267
• 28 Tillinger W, Mittermaier C, Lochs H, Moser G. Health-related quality of life in patients with Crohn's disease - influence of surgical operation: a prospective trial.  Dig Dis Sci. 1999;  44 932-938
• 29 Tiainen J, Matikainen M, Hiltunen KM. Ileal J-pouch: anal anastomosis, sexual dysfunction, and fertility.  Scand J Gastroenterol. 1999;  34 185-188
• 30 Sarigol  S, Wyllie R, Gramlich T, et al. Incidence of dysplasia in pelvic pouches in pediatric patients after ileal pouch-anal anastomosis for ulcerative colitis. .  J Pediatr Gastroenterol Nutr. 1999;  28 429-434
• 31 Vega  R, Bertran X, Menacho M, et al. Cytomegalovirus infection in patients with inflammatory bowel disease.  Am J Gastroenterol. 1999;  94 1053-1056
• 32 Kaufman  HS, Kahn AC, Iacobuzio-Donahue C, et al. Cytomegaloviral enterocolitis: clinical associations and outcome.  Dis Colon Rectum. 1999;  42 24-30
• 33 Yanai H, Shimizu N, Nagasaki S, et al. Epstein-Barr virus infection of the colon with inflammatory bowel disease.  Am J Gastroenterol. 1999;  94 1582-1586
• 34 Karlen P, Lofberg R, Brostrom O, et al. Increased risk of cancer in ulcerative colitis: a population-based cohort study.  Am J Gastroenterol. 1999;  94 1047-1052
• 35 Shetty K, Rybicki L, Brzezinski A, et al. The risk for cancer or dysplasia in ulcerative colitis patients with primary sclerosing cholangitis.  Am J Gastroenterol. 1999;  94 1643-1649
• 36 Nuako  KW, Ahlquist DA, Mahoney DW, et al. Familial predisposition for colorectal cancer in chronic ulcerative colitis: a case-control study.  Gastroenterology. 1999;  115 1079-1083
• 37 Chan JL, Tersmette AC, Offerhaus GJ, et al. Cancer risk in collagenous colitis.  Inflamm Bowel Dis. 1999;  5 40-43
• 38 Sigel JE, Petras RE, Lashner BA, et al. Intestinal adenocarcinoma in Crohn's disease: a report of 30 cases with a focus on coexisting dysplasia.  Am J Surg Pathol. 1999;  23 651-655
• 39 Green S, Stock RG, Greenstein AJ. Rectal cancer and inflammatory bowel disease: natural history and implications for radiation therapy.  Int J Radiat Oncol Biol Phys. 1999;  44 835-840
• 40 Willenbucher  RF, Aust DE, Chang CG, et al. Genomic instability is an early event during the progression pathway of ulcerative-colitis-related neoplasia.  Am J Pathol. 1999;  154 1825-1830
• 41 Brand S, Stepp H, Ochsenkuhn TH, et al. Detection of colonic dysplasia by light-induced fluorescence endoscopy: a pilot study.  Int J Colorectal Dis. 1999;  14 63-68
• 42 Lang SM, Stratakis DF, Heinzlmann M, et al. Molecular screening of patients with long standing extensive ulcerative colitis: detection of p53 and Ki-ras mutations by single strand conformation polymorphism analysis and differential hybridisation in colonic lavage fluid.  Gut. 1999;  44 822-825
• 43 D'Haens  G, Van Deventer S, Van Hogezand R, et al. Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn's disease: a European multicenter trial.  Gastroenterology. 1999;  116 1029-1034
• 44 Present  DH, Rutgeerts P, Targan S, et al. Infliximab for the treatment of fistulas in patients with Crohn's disease.  N Engl J Med. 1999;  340 1398-1405
• 45 Aitola P, Hiltunen KM, Matikainen M. Fibrin glue in perianal fistulas: a pilot study.  Ann Chir Gynaecol. 1999;  88 136-138
• 46 Canin-Endres J, Salky B, Gattorno F, Edye M. Laparoscopically assisted intestinal resection in 88 patients with Crohn's disease.  Surg Endosc. 1999;  13 595-599