Int J Sports Med 2000; 21(7): 480-484
DOI: 10.1055/s-2000-7422
Physiology and Biochemistry
Georg Thieme Verlag Stuttgart · New York

Effects of Acute Ingestion of Salbutamol During Submaximal Exercise

K. Collomp1, 2 ,  R. Candau3 ,  R. Collomp4 ,  J. Carra3 ,  F. Lasne1 ,  C. Préfaut5 ,  J. De Ceaurriz1
  • 1 Laboratoire National de Dépistage du Dopage, Chatenay-Malabry, France
  • 2 EA 1609, Division STAPS, UFR Scientifique d'Orsay, Orsay, France
  • 3 JE 147, Faculté des Sciences du Sport, Montpellier, France
  • 4 Pharmacie centrale, CHU L'Archer, Nice, France
  • 5 Service Central de Physiologie Clinique, Hôpital A. de Villeneuve, Montpellier, France
Further Information

Publication History

Publication Date:
31 December 2000 (online)

To assess the eventual effects of acute oral salbutamol intake on performance and metabolism during submaximal exercise, nine healthy volunteers completed two cycling trials at a power corresponding to 80 - 85 % V˙O2max, after either placebo (Pla) or salbutamol (Sal, 6 mg) treatment, according to a double-blind randomized protocol. Blood samples were collected both at rest and during exercise (5 min-, 10 min-, 15 min-exhaustion) for C-peptide, FFA, lactate and blood glucose measurements. Cycling performance was significantly improved in the Sal vs. Pla trials (p < 0.05). After Sal intake, resting C-peptide, lactate, FFA and blood glucose values were higher whereas exercise lactate and free fatty acid concentrations were greater during and at the conclusion of the exercise period (p < 0.05). These results suggest that acute salbutamol ingestion improved performance during submaximal exercise probably through an enhancement of the overall contribution to energy production from both aerobic and anaerobic metabolisms.

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Katia Collomp

Laboratoire National de Dépistage du Dopage CREPS

143, Av Roger Salengro 92290 Chatenay-Malabry France

Phone: Phone:+ 33 (1) 46602869

Fax: Fax:+ 33 (1) 46603017

Email: E-mail:katia.collomp@staps.u-psud.fr

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