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Semin Liver Dis 2000; Volume 20(Number 03): 307-322
DOI: 10.1055/s-2000-9386
DOI: 10.1055/s-2000-9386
Short-Term Regulation of Canalicular Transport
Further Information
Publication History
Publication Date:
31 December 2000 (online)
ABSTRACT
On a short term basis, canalicular secretion is under control of the hepatocellular hydration state, substrates, cytokines, toxins, and hormones. Regulation occurs at the level of substrate availability, covalent modification of transporters, and their regulated exocytic insertion into or endocytic retrieval from the membrane. A variety of signal transduction pathways involving the activation of mitogen-activated protein kinases, protein kinases A and C, participates in these processes. However, much has still to be learned about the crosstalk of different signaling systems and their molecular targets that determine the outcome for canalicular secretion.
KEYWORD
bile secretion - ABC-transporter - cell volume - transporter targeting
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