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J Reconstr Microsurg 2001; 17(1): 039-044
DOI: 10.1055/s-2001-12687
Copyright © 2001 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Basic Fibroblast Growth Factor Induced Angiogenesis and Prefabricated Flap Survival

Melinda J. Haws1 , Detlev Erdman2 , Semira Bayati2 , Richard E. Brown2 , Robert C. Russell2
  • 1Microsurgery and Hyperbaric Laboratory, Division of Plastic Surgery, University of Nevada School of Medicine, Las Vegas, Nevada
  • 2Institute for Plastic and Reconstructive Surgery, Department of Surgery, Southern Illinois University School of Medicine, Springfield, Illinois
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Publication History

Publication Date:
31 December 2001 (online)

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ABSTRACT

Prefabrication of a latissimus dorsi myocutaneous flap was performed in adult male Landrace pigs. Gelfoam sponges were used as a delivery system for basic fibroblast growth factor (bFGF) at the muscle-subcutaneous tissue interface. Skin survival and angiogenesis were augmented in the growth-factor-treated animals. These data support the use of basic fibroblast growth factor to enhance flap prefabrication.

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