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Sleep Breath 2001; 05(1): 035-042
DOI: 10.1055/s-2001-12790
DOI: 10.1055/s-2001-12790
REVIEW ARTICLE
Copyright © 2001 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662
Morbidity of Obstructive Sleep Apnea in Children: Facts and Theory
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
31. Dezember 2001 (online)
ABSTRACT
Sleep-disordered breathing (SDB) is a frequent, albeit underdiagnosed, problem in children. If left untreated, SDB may lead to substantial morbidities affecting multiple target organs and systems. This review provides a detailed and current description of the current status of our understanding of SDB-associated morbidity in children, and provides recommendations of future research directions necessary for increasing our knowledge and awareness on the short- and long-term consequences of SDB during childhood.
KEYWORD
Obstructive sleep apnea - respiratory control - craniofacial - sleep - apnea - tonsils - adenoids - upper airway - pharynx - snoring - hypertension
REFERENCES
- 1 Ali N J, Pitson D, Stradling J R. Snoring, sleep disturbance, and behaviour in 4-5 year olds. Arch Dis Child . 1993; 68 360-366
- 2 Corbo G M, Fuciarelli F, Foresi A, De Benedetto F. Snoring in children: association with respiratory symptoms and passive smoking [published erratum appears in BMJ 1990;300:226]. BMJ . 1989; 299 1491-1494
- 3 Owen G O, Canter R J, Robinson A. Snoring, apnoea and ENT symptoms in the paediatric community. Clin Otolaryngol . 1996; 21 130-134
- 4 Hulcrantz E, Löfstrand T B, Ahlquist R J. The epidemiology of sleep related breathing disorders in children. Int J Pediatr Otorhinolaryngol . 1995; 6(suppl) S63-S66
- 5 Ferreira A M, Clemente V, Gozal D. Snoring in Portuguese primary school children. Pediatrics [online] 2000; 106:e64. Available at:http://www.pediatrics.org/cgi/ content/full/106/5/e64
MissingFormLabel
- 6 Marcus C L, Omlin K J, Basinski D J. Normal polysomnographic values for children and adolescents. Am Rev Respir Dis . 1992; 146 1235-1239
- 7 Redline S, Tishler P V, Schluchter M. Risk factors for sleepdisordered breathing in children. Associations with obesity, race, and respiratory problems. Am J Respir Crit Care Med . 1999; 159 1527-1532
- 8 Marcus C L. Pathophysiology of childhood obstructive sleep apnea: current concepts. Respir Physiol . 2000; 119 143-154
- 9 Richards W, Ferdman R M. Prolonged morbidity due to delays in the diagnosis and treatment of obstructive sleep apnea in children. Clin Pediatr . 2000; 39 103-108
- 10 Rosen C L. Clinical features of obstructive sleep apnea hypoventilation syndrome in otherwise healthy children. Pediatr Pulmonol . 1999; 27 403-409
- 11 Marcus C L, Hamer A, Loughlin G M. Natural history of primary snoring in children. Pediatr Pulmonol . 1998; 26 6-11
- 12 Brouillette R T, Hanson D, David R. Diagnostic approach to suspected obstructive sleep apnea in children. J Pediatr . 1984; 105 10-14
- 13 Kahn A, Groswasser J, Sottiaux M. Clinical symptoms associated with brief obstructive sleep apnea in normal infants. Sleep . 1993; 16 409-413
- 14 Carroll J L, McColley S A, Marcus C L. Inability of clinical history to distinguish primary snoring from obstructive sleep apnea syndrome in children. Chest . 1995; 108 610-618
- 15 Wang R C, Elkins T P, Keech D. Accuracy of clinical evaluation in pediatric obstructive sleep apnea. Otolaryngol Head Neck Surg . 1998; 118 69-73
- 16 Suen J S, Arnold J E, Brooks L J. Adenotonsillectomy for treatment of obstructive sleep apnea in children. Arch Otolaryngol Head Neck Surg . 1995; 121 525-530
- 17 Brooks L J, Stephens B M, Bacevice A M. Adenoid size is related to severity but not the number of episodes of obstructive apnea in children. J Pediatr . 1998; 132 682-686
- 18 Goldstein N A, Sculerati N, Walsleben J A. Clinical diagnosis of pediatric obstructive sleep apnea validated by polysomnography. Otolaryngol Head Neck Surg . 1994; 111 611-617
- 19 Tilley A J, Empson J AC. REM sleep and memory consolidation. Biol Psychol . 1978; 6 293-300
- 20 Stepansky E, Lamphere J, Badia P. Sleep fragmentation and daytime sleepiness. Sleep . 1984; 7 18-26
- 21 Stepansky E, Lamphere J, Roehrs T. Experimental sleep fragmentation in normal subjects. Int J Neurosci . 1987; 33 207-214
- 22 Bonnett M H. The effect of sleep disruption on performance, sleep and mood. Sleep . 1985; 8 11-19
- 23 Gottlieb D J, Whitney C W, Bonekat W H. Relation of sleepiness to respiratory disturbance index: the Sleep Heart Health Study. Am J Respir Crit Care Med . 1999; 159 502-507
- 24 Cirelli C, Shaw P J, Rechtschaffen A, Tononi G. No evidence of brain cell degeneration after longterm sleep deprivation in rats. Brain Res . 1999; 840 184-193
- 25 Cirelli C, Tononi G. Differences in brain gene expression between sleep and waking as revealed by mRNA differential display and cDNA microarray technology. J Sleep Res . 1999; 8(suppl 1) 44-52
- 26 Spiegel K, Leproult R, Van Cauter E. Impact of sleep debt on metabolic and endocrine function. Lancet . 1999; 354 1435-1439
- 27 Spiegel K, Leproult R, Colecchia E F. Adaptation of the 24h growth hormone profile to a state of sleep debt. Am J Physiol . 2000; 279 R874-R883
- 28 Muenter N K, Watenpaugh D E, Wasmund W L. Effect of sleep restriction on orthostatic cardiovascular control in humans. J Appl Physiol . 2000; 88 966-972
- 29 Kato M, Phillips B G, Sigurdsson G. Effects of sleep deprivation on neural circulatory control. Hypertension . 2000; 35 1173-1175
- 30 Krueger J M, Obal Jr F, Fang J. Humoral regulation of physiological sleep: cytokines and GHRH. J Sleep Res . 1999; 8(suppl 1) 53-59
- 31 Hall M, Baum A, Buysse D J. Sleep as a mediator of the stress-immune relationship. Psychosom Med . 1998; 60 48-51
- 32 Renegar K B, Floyd R A, Krueger J M. Effects of shortterm sleep deprivation on murine immunity to influenza virus in young adult and senescent mice. Sleep . 1998; 21 241-248
- 33 Rosen C L, D'Andrea L, Haddad G G. Adult criteria for obstructive sleep apnea do not identify children with serious obstruction. Am Rev Respir Dis . 1992; 146 1231-1234
- 34 McNamara F, Issa F G, Sullivan C E. Arousal pattern following central and obstructive breathing abnormalities in infants and children. J Appl Physiol . 1996; 81 2651-2657
- 35 Marcus C L, Lutz J, Carroll J L, Bamford O. Arousal and ventilatory responses during sleep in children with obstructive sleep apnea. J Appl Physiol . 1998; 84 1926-1936
- 36 Goh D Y, Galster P, Marcus C L. Sleep architecture and respiratory disturbances in children with obstructive sleep apnea. Am J Respir Crit Care Med . 2000; 162 682-686
- 37 Bandla H PR, Gozal D. Dynamic changes in EEG spectra during obstructive apnea in children. Pediatr Pulmonol . 2000; 29 359-365
- 38 Everett A D, Koch W C, Saulsbury F T. Failure to thrive due to obstructive sleep apnea. Clin Pediatr . 1987; 26 90-92
- 39 Ahlqvist-Rastad J, Hutcrantz E, Melander H. Body growth in relation to tonsillar enlargement and tonsillectomy. Int J Pediatr Otorhinolaryngol . 1992; 24 55-61
- 40 Freezer N J, Bucens I K, Robertson C F. Obstructive sleep apnoea presenting as failure to thrive in infancy. J Paediatr Child Health . 1995; 31 172-175
- 41 Soultan Z, Wadowski S, Rao M, Kravath R E. Effect of treating obstructive sleep apnea by tonsillectomy and/or adenoidectomy on obesity in children. Arch Pediatr Adolesc Med . 1999; 153 33-37
- 42 Waters K A, Kirjavainen T, Jimenez M. Overnight growth hormone secretion in achondroplasia: deconvolution analysis, correlation with sleep state, and changes after treatment of obstructive sleep apnea. Pediatr Res . 1996; 39 547-553
- 43 Marcus C L, Carroll J L, Koerner C B. Determinants of growth in children with the obstructive sleep apnea syndrome. J Pediatr . 1994; 125 556-562
- 44 Cooper B G, White J E, Ashworth L A. Hormonal and metabolic profiles in subjects with obstructive sleep apnea syndrome and the acute effects of nasal continuous positive airway pressure (CPAP) treatment. Sleep . 1995; 18 172-179
- 45 Bar A, Tarasiuk A, Segev Y. The effect of adenotonsillectomy on serum insulin-like growth factor-I and growth in children with obstructive sleep apnea syndrome. J Pediatr . 1999; 135 76-80
- 46 Morielli A, Desjardins D, Brouillette R T. Transcutaneous and end-tidal carbon dioxide pressures should be measured during pediatric polysomnography. Am Rev Respir Dis . 1993; 148 1599-1604
- 47 Verbraecken J, Willemen M, De Cock W. Relationship between CO2 drive and characteristics of apneas in obstructive and central sleep apnea. Respir Physiol . 1998; 114 185-194
- 48 Marcus C L, Gozal D, Arens R. Ventilatory and cardiac responses to hypercapnea and hypoxia during wakefulness in children with the obstructive sleep apnea syndrome. Am J Respir Crit Care Med . 1994; 149 715-721
- 49 Diomedi M, Placidi F, Cupini L M. Cerebral hemodynamic changes in sleep apnea syndrome and effect of continuous positive airway pressure treatment. Neurology . 1998; 51 1051-1056
- 50 Loeppky J A, Miranda F G, Eldridge M W. Abnormal cerebrovascular responses to CO2 in sleep apnea patients. Sleep . 1984; 7 97-109
- 51 Balfors E M, Franklin K A. Impairment of cerebral perfusion during obstructive sleep apneas. Am J Respir Crit Care Med . 1994; 150 1587-1591
- 52 Hayakawa T, Terashima M, Kayukawa Y. Changes in cerebral oxygenation and hemodynamics during obstructive sleep apneas. Chest . 1996; 109 916-921
- 53 Ficker J H, Feistel H, Moller C. Changes in regional CNS perfusion in obstructive sleep apnea syndrome: initial SPECT studies with injected nocturnal 99mTcHMPAO. Pneumologie . 1997; 51 926-930
- 54 Shiomi T, Guilleminault C, Stoohs R, Schnittger I. Obstructed breathing in children during sleep monitored by echocardiography. Acta Paediatr . 1993; 82 863-871
- 55 Tal A, Leiberman A, Margulis G, Sofer S. Ventricular dysfunction in children with obstructive sleep apnea: radionuclide assessment. Pediatr Pulmonol . 1988; 4 139-143
- 56 Fletcher E C. Effect of episodic hypoxia on sympathetic activity and blood pressure. Respir Physiol . 2000; 119 189-197
- 57 Fletcher E C, Bao G, Li R. Renin activity and blood pressure in response to chronic episodic hypoxia. Hypertension . 1999; 34 309-314
- 58 Kraiczi H, Hedner J, Peker Y, Carlson J. Increased vasoconstrictor sensitivity in obstructive sleep apnea. J Appl Physiol . 2000; 89 493-498
- 59 Loredo J S, Ziegler M G, AncoliIsrael S. Relationship of arousals from sleep to sympathetic nervous system activity and BP in obstructive sleep apnea. Chest . 1999; 116 655-659
- 60 Khoo M C, Kim T S, Berry R B. Spectral indices of cardiac autonomic function in obstructive sleep apnea. Sleep . 1999; 22 443-451
- 61 Brooks D, Horner R L, Floras J S. Baroreflex control of heart rate in a canine model of obstructive sleep apnea. Am J Respir Crit Care Med . 1999; 159 1293-1297
- 62 Peled N, Greenberg A, Pillar G. Contributions of hypoxia and respiratory disturbance index to sympathetic activation and blood pressure in obstructive sleep apnea syndrome. Am J Hypertens . 1998; 11 1284-1289
- 63 Duchna H W, Guilleminault C, Stoohs R A. Vascular reactivity in obstructive sleep apnea syndrome. Am J Respir Crit Care Med . 2000; 161 187-191
- 64 Phillips B G, Somers V K. Neural and humoral mechanisms mediating cardiovascular responses to obstructive sleep apnea. Respir Physiol . 2000; 119 181-187
- 65 Aljadeff G, Gozal D, Shechtman V L. Heart rate variability in children with obstructive sleep apnea. Sleep . 1997; 20 151-157
- 66 Baharav A, Kotagal S, Rubin B K. Autonomic cardiovascular control in children with obstructive sleep apnea. Clin Auton Res . 1999; 9 345-351
- 67 Marcus C L, Greene M G, Carroll J L. Blood pressure in children with obstructive sleep apnea. Am J Respir Crit Care Med . 1998; 157 1098-1103
- 68 Hill W. On some causes of backwardness and stupidity in children: and the relief of the symptoms in some instances by nasopharyngeal scarifications. BMJ . 1889; 2 711-712
- 69 Weissbluth M, Davis A, Poncher J, Reiff J. Signs of airway obstruction during sleep and behavioral, developmental and academic problems. Dev Behav Pediatr . 1983; 4 119-121
- 70 Leach J, Olson J, Hermann J, Manning S. Polysomnographic and clinical findings in children with obstructive sleep apnea. Arch Otolaryngol Head Neck Surg . 1992; 118 741-744
- 71 Singer L P, Saenger P. Complications of pediatric obstructive sleep apnea. Otolaryngol Clin North Am . 1990; 23 665-676
- 72 Guilleminault C, Korobkin R, Winkle R. A review of 50 children with obstructive sleep apnea syndrome. Lung . 1981; 159 275-287
- 73 Chervin R, Dillon J, Bassetti C. Symptoms of sleep disorders, inattention, and hyperactivity in children. Sleep . 1997; 20 1185-1192
- 74 Owens J, Opipari L, Nobile C, Spirito A. Sleep and daytime behavior in children with obstructive sleep apnea and behavioral sleep disorders. Pediatrics . 1998; 102 1178-1184
- 75 Ali N J, Pitson D, Stradling J R. Sleep disordered breathing: effects of adenotonsillectomy on behaviour and psychological functioning. Eur J Pediatr . 1996; 155 56-62
- 76 Rhodes S K, Shimoda K C, Wald L R. Neurocognitive deficits in morbidly obese children with obstructive sleep apnea. J Pediatr . 1995; 127 741-744
- 77 Gozal D. Sleep-disordered breathing and school performance in children. Pediatrics . 1998; 102 616-620
- 78 Gozal D, Pope D W. Long-term impact of snoring during early childhood on academic performance in middle school. Sleep . 2000; 23(suppl 2) A29
- 79 Daniel J M, Chen J, Xue Y D. Effect of chronic intermittent daytime hypoxia on maze performance, NMDA receptor and c-fos expression in the neocortex and hippocampus of adult rats. Sleep Res Online (www.sro.org) . 1999; 2(suppl 1) 344