Microwave-Assisted Parallel Synthesis of a 2-Aryl-1H-Isoindole-1,3-Dione Library

Abstract

An efficient parallel synthesis of a representative 28-member library of phthalimides is described. Parallel chromatography afforded the library members in suitable purity and with high yields.

Key words

library - microwave - phthalimide - 2-aryl-1H-isoindole-1,3-dione - TNF-α

References

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11

Acquired from International Sorbent Technology Ltd., U.K.

12

Savant Automatic Environmental SpeedVac (AES 2000) was used.

13

Microsoft® Excel 97 was used.

22

Hokko Chemical Industry Co. Ltd., Jpn. Kokai Tokkyo Koh, 1980, Jp55136210A2; Chem. Abstr. 1980, 94, 78435.