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Semin Vasc Med 2002; 2(1): 097-108
DOI: 10.1055/s-2002-23100
Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Nephropathy in Type 1 Diabetes

Michel Marre
  • Service d'Endocrinologie Diabétologie Métabolisme Nutrition, Centre Hospitalier Universitaire Bichat-Claude Bernard, Paris, France
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Publication History

Publication Date:
25 March 2002 (online)

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ABSTRACT

Nephropathy is the major life-threatening complication of type 1 diabetes. It is due to the adverse effects of glucose-induced preglomerular vasodilation on glomerular hemodynamics. Glomerulosclerosis is initiated early in the course of diabetic nephropathy by exacerbated expression of cytokines like tumor growth factor β1. Not all type 1 diabetes patients are at risk of nephropathy, probably because some polymorphisms in the various factors involved in its pathogenesis can modulate the course of this disease from one individual to another. Blocking the course of nephropathy by blockers of the renin-angiotensin system relies on solid pathophysiological hypotheses and has proved to be efficacious for improving the prognosis of type 1 diabetes nephropathy.

KEYWORD

Type 1 diabetes - nephropathy - glomerular disease - albuminuria - angiotensin converting enzyme - genetics - transforming growth factors β1

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