ABSTRACT
Colonoscopy and polypectomy are being performed in increasing numbers. Pathologic
review of the polyps occasionally demonstrates the presence of invasive carcinoma.
This challenges the clinician to determine whether to recommend observation and colonoscopic
follow-up or a surgical resection to the patient. Management of this peculiar condition
is based on an understanding of colorectal carcinoma, colonic anatomy, and endoscopy.
Specific principles of polyp evaluation include complete endoscopic excision, proper
histologic orientation, and pathologic evaluation of the polyp (assessment of tumor
grade and margin of excision). Retrospective studies have evaluated many of these
features. Until additional studies of tumor biology are available, previous studies
suggest that polyps that have been completely excised with clear margins along with
the absence of poor differentiation and lymphovascular invasion can be observed and
followed with colonoscopy. Patients with polyps that do not meet these criteria who
are acceptable surgical risks should undergo surgical resection. Adherence to these
recommendations has produced excellent long-term survival and minimized unnecessary
surgical resections.
KEYWORDS
Polyp - malignant - carcinoma - endoscopy - polypectomy