A Simple Protocol for the One Pot Synthesis of Chiral Secondary Benzylic Alcohols by Catalytic Enantioselective Reduction of Aromatic Ketones

Viviana L. Ponzo; Teodoro S. Kaufman

doi:10.1055/s-2002-32598

LETTER

A Simple Protocol for the One Pot Synthesis of Chiral Secondary Benzylic Alcohols by Catalytic Enantioselective Reduction of Aromatic Ketones

Viviana L. Ponzo, Teodoro S. Kaufman*
Instituto de Química Orgánica de Síntesis -IQUIOS- (CONICET-UNR) and Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Casilla de Correo 991, S2000WAJ Rosario, República Argentina
Fax: +54(341)4370477; e-Mail: tkaufman@fbioyf.unr.edu.ar;

Abstract

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Abstract

A simple and efficient protocol for the one-pot catalytic enantioselective reduction of prochiral aromatic ketones mediated by in situ prepared catalysts derived from (S)-(-)-diphenyl-pyrrolidin-2-yl-methanol, is reported.

Key words

enantioselective reduction - chiral alcohols - oxazaborolidines - chiral catalysts - one-pot reaction

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References

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