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Semin Liver Dis 2002; 22(4): 379-386
DOI: 10.1055/s-2002-35707
Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Transplantation for Autoimmune Hepatitis

James Neuberger
  • Liver Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom
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Publication History

Publication Date:
25 November 2002 (online)

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ABSTRACT

Autoimmune hepatitis (AIH) is a good indication for liver transplantation, with 5- and 10-year survival rates approaching 75%. Determining the timing for transplantation remains difficult because progression to end-stage disease may be difficult to predict. After transplantation, the patients are at risk of recurrent AIH. This syndrome is not well-characterized and requires clearer definition. Introduction of corticosteroids is not always associated with arrest of disease. De novo AIH may also develop in the allograft. Although there is usually a good response to the reintroduction of corticosteroids or greater immunosuppression, some patients develop graft failure. Patients grafted for AIH tend to be at higher risk for both acute and chronic rejection. Withdrawal of immunosuppression is unlikely to be achieved.

KEYWORDS

Autoimmune hepatitis - liver transplantation - recurrent autoimmune hepatitis

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