New Polymer-Supported Allyloxycarbonyl (Alloc) and Propargyloxycarbonyl (Proc) Amino-Protecting Reagents

Abstract

New polymer-supported reagents, Alloc-P-OSu and Proc-P-OSu, have been prepared from a polymeric N-hydroxysuccinimide (P-HOSu), and used as solid-supported reagents for the allyloxycarbonyl (Alloc) and propargyloxycarbonyl (Proc) protection of the amino group. These new polymeric reagents are safe and stable, the residual P-HOSu generated after the protection reaction can be easily separated by simple filtration and reused.

amino acids - polymers - protecting reagents - solid-supported reagents

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