Endoscopy 2003; 35(8): 717
DOI: 10.1055/s-2003-41507
Unusual Cases and Technical Notes
© Georg Thieme Verlag Stuttgart · New York

Severe Hyperphosphatemia and Hypocalcemia Following Sodium Phosphate Bowel Preparation: A Forgotten Menace

K.  K.  Ma1 , C.  S. H.  Ng1 , L.  M.  Mui1 , K.  C.  Chan1 , E.  K. W.  Ng1 , S.  C. S.  Chung1
  • 1Dept. of Surgery, Chinese University of Hong Kong, Prince of Wales Hospital, Sha Tin, New Territories, Hong Kong
Further Information

S. S. C. Chung, M.D.

Division of UpperGastrointestinal Surgery
Department of Surgery
The Chinese University of Hong Kong

Sha Tin, NT
Hong Kong

Fax: + 852-2635-0075

Email: sydneychung@cuhk.edu.hk

Publication History

Publication Date:
20 August 2003 (online)

Table of Contents

A 74-year-old woman was scheduled for colonoscopy due to positive fecal occult blood. On admission, her serum levels of creatinine, adjusted calcium, and phosphate were 113 µmol/l, 2.24 mmol/l, and 1.17 mmol/l, respectively. She received 90 ml of oral Fleet Phospho-Soda (C.B. Fleet Co. Inc., Lynchburg, Virginia, USA), from which she developed profuse diarrhea. Six hours later, she complained of facial and limb numbness, and appeared drowsy. Her serum phosphate level had risen to 7.29 mmol/l and her calcium level had fallen to 1.82 mmol/l. During the next hour, muscle cramps and tetany developed over her lower limbs, trunk, and face, with a positive Chvostek’s sign. Intravenous administration of 9.0 mmol (40 ml 10 %) calcium gluconate was carried out over 6 h, resulting in resolution of her tetany, while the numbness persisted over the distal limbs. Further infusions totaling 24.75 mmol calcium gluconate were required over the next 17 h to restore the calcium level to 2.32 mmol/l (Figure [1]). Extensive investigations excluded a secondary cause of the electrolyte disturbance.

Zoom Image

Figure 1 Chart illustrating the evolving signs and symptoms, serum calcium and phosphate derangement, and calcium replacement therapy given.

Most complications of sodium phosphate bowel preparation are the result of hyperphosphatemia after rapid phosphate absorption and subsequent binding to serum calcium, causing secondary hypocalcemia [1]. Patients usually present 6 - 12 h after ingestion, with abdominal pain, vomiting, dizziness, muscle cramping, or seizures [2]. Other associated electrolyte disturbances include hypokalemia, hypernatremia, and metabolic acidosis, with increased anion gap [3]. Excessive diarrhea can lead to significant potassium and bicarbonate loss, contributing to hypokalemia and metabolic acidosis [2]. Hypernatremia is secondary to intestinal absorption of sodium from Phospho-Soda, dehydration, and colonic shifting between sodium and potassium.

Factors exacerbating hyperphosphatemia are old age, impaired renal function with reduced phosphate clearance, dehydration, bowel immotility, and repeated dosing. Symptomatic hyperphosphatemia and hypocalcemia are very uncommon in patients with normal renal function [4]. The aims of treatment are to reduce phosphate absorption by oral phosphate binders (calcium acetate or Alusorb), to increase phosphate clearance, and to correct dehydration and electrolyte disturbances. Care must be taken when giving calcium supplement, as renal calcium-phosphate precipitation may further deteriorate renal function [2].

This unusual case is a dramatic reminder that patients with normal renal function may rapidly develop symptomatic hypocalcemia and hyperphosphatemia after a single dose of oral Phospho-Soda.

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References

  • 1 Boivin M A, Kahn S R.. Symptomatic hypocalcemia from oral sodium phosphate: a report of two cases.  Am J Gastroenterol. 1998;  93 2577-2579
  • 2 Tan H L, Liew Q Y, Loo S. et al. . Severe hyperphosphataemia and associated electrolyte and metabolic derangement following the administration of sodium phosphate for bowel preparation.  Anaesthesia. 2002;  57 478-483
  • 3 Kirschbaum B.. The acidosis of exogenous phosphate intoxication.  Arch Intern Med. 1998;  158 405-408
  • 4 Lieberman D A, Ghormley J, Flora K.. Effect of oral sodium phosphate colon preparation on serum electrolytes in patients with normal serum creatinine.  Gastrointest Endosc. 1996;  43 467-469

S. S. C. Chung, M.D.

Division of UpperGastrointestinal Surgery
Department of Surgery
The Chinese University of Hong Kong

Sha Tin, NT
Hong Kong

Fax: + 852-2635-0075

Email: sydneychung@cuhk.edu.hk

#

References

  • 1 Boivin M A, Kahn S R.. Symptomatic hypocalcemia from oral sodium phosphate: a report of two cases.  Am J Gastroenterol. 1998;  93 2577-2579
  • 2 Tan H L, Liew Q Y, Loo S. et al. . Severe hyperphosphataemia and associated electrolyte and metabolic derangement following the administration of sodium phosphate for bowel preparation.  Anaesthesia. 2002;  57 478-483
  • 3 Kirschbaum B.. The acidosis of exogenous phosphate intoxication.  Arch Intern Med. 1998;  158 405-408
  • 4 Lieberman D A, Ghormley J, Flora K.. Effect of oral sodium phosphate colon preparation on serum electrolytes in patients with normal serum creatinine.  Gastrointest Endosc. 1996;  43 467-469

S. S. C. Chung, M.D.

Division of UpperGastrointestinal Surgery
Department of Surgery
The Chinese University of Hong Kong

Sha Tin, NT
Hong Kong

Fax: + 852-2635-0075

Email: sydneychung@cuhk.edu.hk

Zoom Image

Figure 1 Chart illustrating the evolving signs and symptoms, serum calcium and phosphate derangement, and calcium replacement therapy given.