Zusammenfassung
Die Mehrzahl aller Parkinson-Patienten entwickelt im Laufe der medikamentösen Therapie
ihrer Erkrankung motorische Probleme wie zunehmend schlechteres Ansprechen auf dopaminerge
Medikation, Fluktuationen und Dyskinesien. Zudem treten häufig nichtmotorische Probleme
wie Demenz, Angst, Depression, autonome Störungen und therapieresistente Phänomene
wie Gangstörungen, Sprechstörungen, Fallneigung und Freezing hinzu. Die Behandlung
dieser Komplikationen stellt eine Herausforderung sowohl für den Arzt als auch für
den Patienten und seine Angehörigen dar. In diesem Artikel werden medikamentöse Therapiestrategien
zur Behandlung von Komplikationen im Spätstadium des M. Parkinson zusammengefasst.
Abstract
The majority of patients with Parkinson's disease experiences motor complications
during long-term treatment of their disease including a decreasing response to dopaminergic
stimulation, motor fluctuations, and dyskinesias. Many patients also develop non-motor
problems such as dementia, depression, autonomic dysfunction and therapy-resistent
phenomena like gait disorders, speech disorders, postural instability, falls, and
freezing. This article summarizes current treatment strategies in the drug management
of motor complications in advanced Parkinson's disease.
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Prof. Dr. Markus Naumann
Neurologische Klinik der Bayerischen Julius-Maximilians-Universität Würzburg
Josef-Schneider-Straße 11
97080 Würzburg
Email: naumann@mail.uni-wuerzburg.de
