Zusammenfassung
Die Haut schützt den Körper vor äußeren Einflüssen (Wärme, Kälte, Verdunstung, UV-Strahlung,
etc.). Sie ist als Organ sehr komplex und aus verschiedenen Schichten aufgebaut. Zum
Schutz funktionell und strukturell wichtiger Biomoleküle (Lipide, Proteine, Nukleinsäuren)
vor Schädigung durch reaktive Sauerstoffspezies (ROS) hat die menschliche Haut im
Laufe der Evolution ein komplexes Abwehrsystem entwickelt. Es besteht aus lipophilen
und hydrophilen, enzymatischen und nicht-enzymatischen antioxidativen Komponenten
und wird als das »antioxidative Netzwerk der Haut« bezeichnet. Vitamin E nimmt als
lipophiles Antioxidans eine entscheidende Rolle in diesem System ein. So schützt es
die Oberflächenlipide vor der Schädigung durch UV-induzierte Lipidperoxidation. Hauteigene,
aber auch systemische und topische antioxidative Strategien sind in der Lage, den
oxidativen Schaden insbesondere in der UV-exponierten Haut signifikant zu begrenzen.
Die in der vorliegenden Arbeit vorgestellten Ergebnisse stellen den kombinierten Einsatz
von Antioxidantien und UV-Filtern zur Prävention UV-induzierter Hautschädigung auf
eine wissenschaftliche Basis.
Summary
The skin is frequently and directly exposed to a prooxidative environment, including
ultraviolet radiation, drugs, and air pollution. Besides external inducers of oxidative
attack, the skin has to cope with endogenous generation of reactive oxygen species
(ROS) and other free radicals. To counteract the oxidative injuries of structural
molecules (lipids, nucleic acids, proteins) caused by ROS, the skin possesses a variety
of antioxidant mechanisms. Together, they form a powerful »antioxidative network«.
It comprises lipophilic and hydrophilic, enzymatic and non-enzymatic antioxidative
components. Vitamin E plays a major role in this system, protecting not only the membranes
of cutaneous cells, but also the lipophilic components of the stratum corneum and
skin surface lipids against lipid peroxidation. Besides natural antioxidative strategies
of the skin, topical and systemic applications are able to significantly prevent oxidative
damage in UV-exposed skin. Thus, basic and clinical research on the photoprotective
properties of antioxidants in skin may help to increase the efficacy of modern sunscreen
formulations.
Schlüsselwörter
Photoaging - Hautalterung - Stratum corneum - oxidativer Stress - Tocopherol - Vitamin
E - Antioxidantien - Barriere - UV-Licht
Key words
Photoaging - cutaneous degeneration - stratum corneum - oxidative stress - tocopherol
- vitamin E - antioxidants - barrier - UV rays
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OA Dr. med. Jens Thiele
Klinik für Dermatologie der Friedrich-Schiller-Universität
Erfurter Straße 35
D-07740 Jena, Deutschland
Email: thiele@derma.uni-jena.de
