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Synlett 2005(4): 619-622
DOI: 10.1055/s-2005-863720
DOI: 10.1055/s-2005-863720
LETTER
© Georg Thieme Verlag Stuttgart · New YorkEasy Copper-, Ligand- and Amine-Free Sonogashira Coupling Reaction Catalyzed by Palladium on Carbon at Low Catalyst Loading and by Exposure to Air
Further Information
Received
27 October 2004
Publication Date:
22 February 2005 (online)
Publication History
Publication Date:
22 February 2005 (online)
Abstract
An easy copper-, ligand and amine-free Sonogashira coupling reaction catalyzed by commercially available palladium on carbon with air at low catalyst loading (0.2 mol% Pd) has been developed. Aryl iodides coupled with aromatic alkynes gave good to excellent yields and with aliphatic alkyne gave moderate to good yields. The reaction system is easy to handle.
Key words
Sonogashira coupling - palladium - catalysis - heterogeneous
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