Enantioselective Synthesis of Chiral α-Aminoalkyl-1,2,3-triazoles Using a Three-Component Reaction

Nina Gommermann; Anna Gehrig; Paul Knochel

doi:10.1055/s-2005-918931

LETTER

Enantioselective Synthesis of Chiral α-Aminoalkyl-1,2,3-triazoles Using a Three-Component Reaction

Nina Gommermann, Anna Gehrig, Paul Knochel*
Ludwig-Maximilians-Universität München, Department Chemie und Biochemie, Butenandtstr. 5-13, Haus F, 81377 München, Germany
Fax: +49(89)218077680; e-Mail: paul.knochel@cup.uni-muenchen.de;

Abstract

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Abstract

A range of chiral α-aminoalkyl-1,2,3-triazoles have been prepared in a modular fashion in 3 steps with up to 98% ee. The key step is a CuBr/Quinap-catalyzed enantioselective asymmetric three-component synthesis of propargylamines.

Key words

alkynes - asymmetric synthesis - C-H activation - copper catalysis - heterocycles

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References

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