Osteosynthesis and Trauma Care 2006; 14(1): 10-15
DOI: 10.1055/s-2006-921363
Original Article

© Georg Thieme Verlag Stuttgart · New York

Extracorporeal Life Support in Traumatology - Review of 9 Patients between 1997 and 2003

H. Wolf1 , G. Pajenda1 , B. Steiner2 , M. Mousavi1 , V. Vécsei1
  • 1Universitätsklinik für Unfallchirurgie, Medizinische Universität Wien, AKH-Wien, Wien, Austria
  • 2Universitätsklinik für Anästhesiologie und Intensivmedizin, Medizinische Universität Wien, AKH-Wien, Wien, Austria
Further Information

Publication History

Publication Date:
02 March 2006 (online)

Abstract

Objective: Polytraumatised patients with lung contusion can mainly be treated by aggressive ventilation techniques in order to maintain sufficient organ O2 perfusion. In rare critical cases adequate tissue oxygenation cannot be achieved, despite high ventilatory procedures. ECMO (extracorporeal membrane oxygenation) can be used for these patients. ECMO is an important part of treatment in trauma patients developing All (acute lung insufficiency), ARDS (adult respiratory distress syndrome) and/or severe hypotension. It is widely accepted that, after fulfilling defined criteria like the Murray lung injury score (LlSS), a pathological Horrowitz index, and chronically elevated peak ventilation pressures, an ECMO is initiated. Methods: This study on 9 trauma patients (6 normothermic, 3 hypothermic) focuses on use of this method in patients in an emergency room or intra- and postoperative setting. Results: Duration time on ECMO in 5 CPR-resuscitated patients was 62.4 hours, in 4 non-resuscitated patients 43.5 hours (chi test p < 0.0036). Three patients suffered from hypothermia after trauma (mean body temperature 22.6 °C). Five patients developed acute hypovolaemic shock and pulmonary failure. In five patients ECMO was initiated in the ER, in one patient intraoperatively during emergency surgery two hours after injury. In three patients ECMO was started in intensive care 24 hours, 48 hours and 5 days after injury. Median duration time of ECMO was 36 hours, average duration 54 hours. CPR was performed in 5 patients, and in 2 non-survivors. The average ISS in total was 22; the average ISS in survivors was 23, in non-survivors 17. The lower ISS in non-survivors results in a lower AIS in the hypothermic patients with minor additional injuries. Three patients died (33 %), 2 of hypothermia, one of MOF after 6 days on ECMO. Four patients survived in good physical health. One patient suffers from tetrapalsy. One suffers from liver dysfunction. Conclusion: This study shows the value of ECMO in acutely injured, critically ill patients during the early period of injury in the ER, OR and ICU. The indications here are pulmonary failure (ARDS), hypovolaemic shock, cardiac support and hypothermia. We conclude therefore that acute ECMO is technically possible in selected trauma patients with severe acute respiratory failure.

References

  • 1 Ashbaugh D G, Bigelow D B, Petty T L. et al . Acute respiratory distress in adults.  Lancet. 1967;  2 319-323
  • 2 Baker S P, O'Neill B, Haddon W, Long W B. The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care.  J Trauma. 1974;  14 187-196
  • 3 Bartlett R H. Extracorporeal life support registry report 1995.  ASAIO J. 1997;  43 104-107
  • 4 Bartlett R H, Roloff D W, Custer J R, Younger J G, Hirschi R B. Extracorporeal life support: the University of Michigan experience.  JAMA. 2000;  283 904-908
  • 5 Bennett J B, Hill J G, Bruhn P S. et al . Heparin-free cardiopulmonary support, utilizing Carmedia coated circuit for a patient with pulmonary hemorrhage and multiple trauma.  J Extra-Corpor Technol. 1992;  23 86
  • 6 Byrne M F, Chong H I, O'Donovan D, Sheehan K M, Leader M B, Kay E. et al . Idiopathic cholangiopathy in a biliary cast syndrome necessitating liver transplantation following head trauma.  Eur J Gastroenterol Hepatol. 2003;  5 415-417
  • 7 Chung C, Buchman A L. Postoperative and total parenteral nutrition-associated hepatic dysfunction.  Clin Liver Dis. 2002;  6 1067-1084
  • 8 Fuchs M, Ullrich R, Kdolsky A, Germann P, Kdolsky R. Extracorporal life support in polytraumatized patients.  Eur J Trauma. 2002;  28 (Suppl 1) 35-36
  • 9 Hill J D, De Leval M R, Fallat R J, Bramson M l, Eberhart R C, Schulte H D, Osborn J J, Barber R, Gerbode F. Acute respiratory insufficiency. Treatment with prolonged extracorporal oxygenation.  J Thorac Cardiovasc Surg. 1972;  64 551-562
  • 10 Holtermann W. et al . When should a patient with severe acute respiratory distress syndrome (ARDS) be transferred to a specialized hospital?.  Wien Med Wochenschr. 1999;  149 345-351
  • 11 http://pediatric.um-surgery.org/new_070 198/new/Library/ECMO.htm
  • 12 Jurkovich G J, Greiser W B, Luterman A, Curreri P W. Hypothermia in trauma victims: an ominous predictor of survival.  J Trauma. 1987;  27 1019-1024
  • 13 Knight G R, Dudell G G, Evans M L, Grimm P S. A comparison of venovenous and venoarterial extracorporeal membrane oxygenation in the treatment of neonatal respiratory failure.  Crit Care Med. 1996;  24 1678-1683
  • 14 Larsen A. Herzchirurgie. In: Anästhesie. Urban und Schwarzenberg, Wien, Baltimore 2000; 1156-1160
  • 15 Lisagor P, Cohen D, McDonnell B, Lawlor D, Moore C. Irreversible shock revisited: A case report and review.  J Trauma. 1997;  42 1182-1186
  • 16 Masiakos P, Hirsch E, Millham F. Management of severe combined pulmonary and myocardial contusion with extracorporeal membrane oxygenation.  J Trauma. 2003;  54 1012-1015
  • 17 Meinhardt J P, Quintel M. Extrakorporale Membranoxygenierung (ECMO) im Erwachsenenalter.  Intensivmed. 2002;  39 694-706
  • 18 Michaels A J, Schriener R J, Kolla S, Awad S, Rich P B, Reickert C. et al . Extracorporal life support in pulmonary failure after trauma.  J Trauma. 1999;  46 638-645
  • 19 Morris A H, Wallace C J, Menlove R L, Clemmer T P, Orme J F, Weaver L K, Dean N C. et al . Randomized clinical trial of pressure-controlled inverse ratio ventilation and extracorporeal CO2 removal for adult respiratory distress syndrome.  Am J Respir Crit Care Med. 1994;  149 295-305
  • 20 O'Rourke P P, Stolar C J, Zwischenberger J B, Snedecor S M, Bartlett R H. Extracorporeal membrane oxygenation: support for overwhelming pulmonary failure in the pediatric population. Collective experience from the extracorporeal life support organization.  J Pediatr Surg. 1993;  28 523-528
  • 21 Perchinsky M J, Long W B, Hill J G. et al . Extracorporal cardiopulmonary life support with heparin-bonded circuitry in the resuscitation of massively injured trauma patients.  Am J Surg. 1995;  169 488
  • 22 Plotkin J S, Shah J B, Lofland G K, DeWolf A M. Extracorporeal membrane oxygenation in the successful treatment of traumatic adult respiratory distress syndrome: case report and review.  J Trauma. 1994;  37 127-130
  • 23 Sasadeuz K, Long W, Kemalyan N, Datena S, Hill J G. Successful treatment of a patient with multiple injuries using extracorporeal membrane oxygenation and inhaled nitric oxide.  J Trauma. 2000;  49 1126-1128
  • 24 Schupp M, Swanevelder J, Peek G J, Sosnowski A W, Spyt T. Postoperative extracorporeal membrane oxygenation for severe intraoperative SIRS 10 h after multiple trauma.  BJA. 2003;  90 91-94
  • 25 Segesser L K. Cardiopulmonary bypass without systemic heparinization.  J Thorac Cardiovasc Surg. 1989;  98 386-396
  • 26 Steiner R B, Adolph V R, Heaton J F, Bonis S L, Falterman K W, Arensman R M. Pediatric extracorporeal membrane oxygenation in posttraumatic respiratory failure.  J Pediatr Surg. 1991;  26 1011-1014
  • 27 Thalmann M, Trampitsch E, Haberfellner N, Eisendle E, Kraschl R, Kobinia G. Resuscitation in near drowning with extracorporeal membrane oxygenation.  Ann Thorac Surg. 2001;  72 607-608
  • 28 Ullrich R, Lorber C, Roder G, Urak G, Faryniak B, Siaden R, Germann P. Controlled airway pressure therapy, nitric oxide inhalation, prone position, and extracorporeal membrane oxygenation (ECMO) as components of an integrated approach to ARDS.  Anesthesiology. 1999;  91 1577-1586
  • 29 Voelckel W, Wenzel V, Rieger M, Antretter H, Padosch S, Schobersberger W. Temporary extracorporeal membrane oxygenation in the treatment of acute traumatic lung injury.  Can J Anaesth. 1998;  45 1097-1102
  • 30 Zapol W M, Snider M T, Hill J D, Fallat R J, Bartlett R H, Edmunds L H, Morris A H, Peirce E C. et al . Extracorporal membrane oxygenation in severe acute respiratory failure. A randomized prospective study.  JAMA. 1979;  242 2193-2196

Dr. H. Wolf

Universitätsklinik für Unfallchirurgie · Medizinische Universität Wien · AKH-Wien

Währinger Gürtel 18-20

1090 Wien

Austria

Phone: +43/1/4 04 00 59 59

Fax: +43/1/4 04 00 59 38

Email: Harald.Wolf@meduniwien.ac.at

    >