An Alternate Hypothesis to Explain the High Frequency of “Revertants” in Hothead Mutants in Arabidopsis

Abstract

Lolle et al. reported a high frequency of genomic changes in Arabidopsis plants carrying the hothead mutation and proposed that the changes observed were the result of a gene correction system mediated by a hypothetical RNA cache. Here, we propose a very different hypothesis to explain the data reported by Lolle et al. Our hypothesis is based on a relatively straightforward developmental aberration in which maternal cells (“Legacy cells”) fuse with the developing embryo, resulting in a chimera, which could then give rise to the aberrant genetic segregations reported by Lolle et al.

Key words

Hothead - legacy cell - non-Mendelian.

References

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Editor: F. Salamini