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Semin Reprod Med 2006; 24(4): 270-282
DOI: 10.1055/s-2006-948556
Copyright © 2006 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Extracellular Matrix of Ovarian Tumors

Carmela Ricciardelli1 , Raymond J. Rodgers1
  • 1Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia, Australia
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Publication History

Publication Date:
30 August 2006 (online)

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ABSTRACT

Tumor cells interfere with the normal programming of extracellular matrix (ECM) biosynthesis and can extensively modify the structure and composition of the matrix. The role of ECM components is becoming increasingly recognized as an important determinant for the growth and progression of solid tumors. The extensive remodeling of the normal ECM in tumors can proceed through the degradation of pre-existing ECM molecules and/or by the neosynthesis of ECM components, which in many cases are not present in the ECM of normal tissues. In the ovary the ECM comprises a variety of molecules including the collagen superfamily and noncollagenous proteins such as glycoproteins, proteoglycans, and hyaluronan. Elevated levels of laminin-γ2, collagen types I and III, fibronectin, syndecan-1, glypican-1, versican, and hyaluronan and its receptors CD44 have all been associated with a poor prognosis of ovarian cancers. Generally, there is a differential expression of laminin chains α1, α4, and β2 among serous (α1, β2), mucinous (α4), and endometrioid (α1) tumors. This review focuses on these and other ECM molecules in ovarian tumors.

KEYWORDS

Ovary - tumor - cancer - metastasis - extracellular matrix - basal lamina - laminin - collagen type IV - tenascin C - hyaluronan - CD44 - decorin - versican - glypican - perlecan - syndecan - fibulin-1

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 Dr.
Carmela Ricciardelli

Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health

University of Adelaide, Adelaide, South Australia 5005, Australia

Email: carmela.ricciardelli@adelaide.edu.au

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