Zusammenfassung
Die semantische Demenz (SemD) gehört neben der primär progressiven Aphasie (PA) und
der frontotemporalen Demenz zur Gruppe der Demenzerkrankungen mit frontotemporaler,
lobärer Degeneration (FTLD). Mittels Positronenemissionstomographie (PET) wurden 8
Patienten mit SemD und 7 Patienten mit PA untersucht. Patienten mit SemD zeigten eine
signifikante Minderung des Glukosestoffwechsels im rechten Temporallappen (Gyrus fusiformis,
Gyrus temporalis inferior) im Vergleich zu den Patienten mit PA. Dieser Befund unterstreicht
die Rolle der PET in der Differenzialdiagnose von Demenzen aus der Gruppe der FTLD.
Abstract
Objective Semantic dementia (SemD) and progressive non-fluent aphasia (PA) are dementia syndromes
associated with frontotemporal lobar degeneration (FTLD). There is evidence for a
common pattern of cerebral glucose metabolism in FTLD. However a few reports exist,
pointing at a differential distribution of cerebral hypometabolism as regards SemD
and PA. The aim of this study was to quest for areas of decreased metabolism in SemD
as compared to PA. Methods 8 patients with SemD and 7 patients with PA were examined using [18F]fluorodeoxyglucose
positron emission tomography. Scans were analysed with statistical parametric mapping
(SPM2). Results A significant decrease in metabolism in SemD as compared to PA was detected in the
right temporal lobe (fusiform gyrus, Brodmann area 37; inferior temporal gyrus, Brodmann
area 19). Conclusions Despite the limited number of patients included, this observation supports previous
results of a left accentuated but bilateral temporal hypometabolism in SemD. These
findings emphasize differences in regional cerebral metabolism as biological correlates
for the different clinical presentations of dementias associated with FTLD.
Schlüsselwörter
frontotemporale lobäre Degeneration - Positronenemissionstomographie - semantische
Demenz - primär progressive Aphasie - SPM2
Key words
frontotemporal lobar degeneration - positron emission tomography - semantic dementia
- progressive non-fluent aphasia - SPM2
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Privatdozent Dr. med. Bernd Ibach
Bezirksklinikum Regensburg
Universitätsstraße 84
93053 Regensburg
Phone: 0941/941-0
Email: bernd.ibach@medbo.de
