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Semin Reprod Med 2006; 24(5): 348-357
DOI: 10.1055/s-2006-952156
Copyright © 2006 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

In Utero Stem Cell Transplantation

Magnus Westgren1
  • 1Professor, Karolinska Institute, Head of Fetal Medicine, Karolinska University Hospital, Stockholm, Sweden
Further Information

Publication History

Publication Date:
22 November 2006 (online)

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ABSTRACT

Successful in utero stem cell transplantations with hematopoietic or other stem cells should represent a major step forward in the management of patients with congenital, hematological, metabolic, and immunological disorders. The possibility of performing cell transplantations with stem cells across histoincompatibility barriers without chemotherapy has great potential for both pre and postnatal transplantations. The present article includes an overview of this topic with special reference to different animal models and the experience in humans in regard to fetal stem cell transplantations.

This area of research holds great promise for the future, and development of efficient intrauterine stem cell treatment may enable the relative new speciality of fetal medicine to progress from a mainly diagnostic to a therapeutic medical subject.

KEYWORDS

Stem cell - fetal transplantation - fetal therapy - hematopoietic stem cell - mesenchymal stem cell

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 Professor
Magnus Westgren

Karolinska Institutet

14186 Stockholm, Sweden

Email: magnus.westgren@klinvet.ki.se

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