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Horm Metab Res 2007; 39(9): 658-664
DOI: 10.1055/s-2007-985372
Review

© Georg Thieme Verlag KG Stuttgart · New York

Emerging Role of SUMO in Pancreatic β-Cells

A. Ehninger 1 , H. Mziaut 1 , M. Solimena 1 , 2
  • 1Experimental Diabetology, Carl Gustav Carus Medical School, Dresden University of Technology, Dresden, Germany
  • 2III° Medical Clinic, Carl Gustav Carus Medical School, Dresden University of Technology, Dresden, Germany
Further Information

Publication History

received 20.11.2006

accepted 18.12.2006

Publication Date:
10 September 2007 (online)

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Abstract

Post-translational attachment of small ubiquitin-like modifier (SUMO), defined as SUMOylation, can affect the localization, interactions, stability and/or activity of substrate proteins, and thus can participate in a large variety of cellular processes. Most SUMO substrates are involved in transcriptional regulation. Hence, SUMOylation can either activate or, more commonly, repress gene transcription. The modulation of gene expression by SUMO through diverse mechanisms and specifically the recent findings concerning SUMOylation in pancreatic β-cells are reviewed.

Key words

insulin - diabetes - ICA512 - PDX-1 - Maf-A - STAT - PIAS

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Correspondence

M. Solimena

Experimental Diabetology

Carl Gustav Carus Medical School

Dresden University of Technology

Fetscherstrasse 74

01307 Dresden

Germany

Phone: +49/351/458 66 11

Fax: +49/351/458 63 30

Email: michele.solimena@tu-dresden.de

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