Experimentelle Behandlung von chronischem Tinnitus: Neue Therapieindikationen für die repetitive Magnetstimulation?

Zusammenfassung

Die Modulation kortikaler Exzitabilität durch transkranielle Stimulationsverfahren ist in den letzten Jahren ein Schwerpunkt in der neurophysiologischer Forschung geworden. Die transkranielle Magnetstimulation (TMS) ist dabei eine Methode zur Untersuchung und Beeinflussung neuronaler Prozesse im intakten menschlichen Gehirn. Veränderungen der kortikalen Exzitabilität sowie Imbalance exzitatorischer und inhibitorischer neuronaler Einflüsse spielen eine Rolle in der Pathophysiologie verschiedener neuropsychiatrischer Krankheiten wie z. B. beim chronischen Tinnitus. Die vorliegende Arbeit bietet eine Übersicht der Studien, welche mittels Applikation repetitiver transkranieller Magnetstimulation (rTMS) versuchten, Tinnituswahrnehmung zu beeinflussen.

Abstract

Modulation of cortical excitability by means of transcranial stimulation has developed as a focus in neurophysiological research. Transcranial magnetic stimulation (TMS) is a useful tool to examine and influence neuronal processes in the intact human brain. Cortical excitability changes as well as imbalances of excitatory and inhibitory influences play a distinct role in the pathophysiology of some neuropsychiatric diseases such as chronic tinnitus. This work reviews studies that have attempted to influence the sensation of tinnitus using repetitive magnetic stimulation (rTMS).

Schlüsselwörter

rTMS - Tinnitus - Neuronavigation

Key words

rTMS - tinnitus - neuronavigation

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