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Aktuelle Neurologie 2008; 35(1): 28-33
DOI: 10.1055/s-2007-986222
Übersicht

© Georg Thieme Verlag KG Stuttgart · New York

Experimentelle Behandlung von chronischem Tinnitus: Neue Therapieindikationen für die repetitive Magnetstimulation?

Experimental Treatment of Chronic Tinnitus: New Therapeutic Indications for Repetitive Magnetic Stimulation?C.  Poreisz1 , N.  Lang1 , 2 , W.  Paulus1
  • 1Abteilung Klinische Neurophysiologie, Georg-August-Universität, Göttingen
  • 2Klinik für Neurologie, Christian-Albrechts-Universität, Kiel
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Publication History

Publication Date:
29 October 2007 (online)

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Zusammenfassung

Die Modulation kortikaler Exzitabilität durch transkranielle Stimulationsverfahren ist in den letzten Jahren ein Schwerpunkt in der neurophysiologischer Forschung geworden. Die transkranielle Magnetstimulation (TMS) ist dabei eine Methode zur Untersuchung und Beeinflussung neuronaler Prozesse im intakten menschlichen Gehirn. Veränderungen der kortikalen Exzitabilität sowie Imbalance exzitatorischer und inhibitorischer neuronaler Einflüsse spielen eine Rolle in der Pathophysiologie verschiedener neuropsychiatrischer Krankheiten wie z. B. beim chronischen Tinnitus. Die vorliegende Arbeit bietet eine Übersicht der Studien, welche mittels Applikation repetitiver transkranieller Magnetstimulation (rTMS) versuchten, Tinnituswahrnehmung zu beeinflussen.

Abstract

Modulation of cortical excitability by means of transcranial stimulation has developed as a focus in neurophysiological research. Transcranial magnetic stimulation (TMS) is a useful tool to examine and influence neuronal processes in the intact human brain. Cortical excitability changes as well as imbalances of excitatory and inhibitory influences play a distinct role in the pathophysiology of some neuropsychiatric diseases such as chronic tinnitus. This work reviews studies that have attempted to influence the sensation of tinnitus using repetitive magnetic stimulation (rTMS).

Schlüsselwörter

rTMS - Tinnitus - Neuronavigation

Key words

rTMS - tinnitus - neuronavigation

Literatur

  • 1 Barker A T, Jalinous R, Freeston I L. Non-invasive magnetic stimulation of human motor cortex.  Lancet. 1985;  11 1106-1107
    PubMedSearch in Google Scholar
  • 2 Siebner H R, Rothwell J. Transcranial magnetic stimulation: new insights into representational cortical plasticity.  Exp Brain Res. 2003;  148 1-16
    CrossrefPubMedSearch in Google Scholar
  • 3 Peinemann A, Reimer B, Löer C. et al . Long-lasting increase in corticospinal excitability after 1800 pulses of subthreshold 5 Hz repetitive TMS to the primary motor cortex.  Clin Neurophysiol. 2004;  115 1519-1526
    CrossrefPubMedSearch in Google Scholar
  • 4 Quartarone A, Bagnato S, Rizzo V. et al . Distinct changes in cortical and spinal excitability following high-frequency repetitive TMS to the human motor cortex.  Exp Brain Res. 2005;  161 114-124
    CrossrefPubMedSearch in Google Scholar
  • 5 Chen R, Classen J, Gerloff C. et al . Depression of motorcortex excitability by low-frequency transcranial magnetic stimulation.  Neurology. 1997;  48 1398-1403
    CrossrefPubMedSearch in Google Scholar
  • 6 Lang N, Harms J, Weyh T. et al . Stimulus intensity and coil characteristics influence the efficacy of rTMS to suppress cortical excitability.  Clin Neurophysiol. 2006;  117 2292-2301
    CrossrefPubMedSearch in Google Scholar
  • 7 George M S, Wassermann E M, Kimbrell T A. et al . Mood improvement following daily left prefrontal repetitive transcranial magnetic stimulation in patients with depression: a placebo-controlled crossover trial.  Am J Psychiatry. 1997;  154 1752-1756
    PubMedSearch in Google Scholar
  • 8 Klein E, Kreinin I, Chistyakov A. et al . Therapeutic efficacy of right prefrontal slow repetitive magnetic stimulation in major depression: a double-blind controlled study.  Arch Gen Psychiatry. 1999;  56 315-320
    PubMedSearch in Google Scholar
  • 9 Menkes D L, Bodnar P, Ballesteros R A, Swenson M R. Right frontal lobe slow frequency repetitive transcranial magnetic stimulation (SF-rTMS) is an effective treatment for depression: a case-control pilot study of safety and efficacy.  J Neurol Neurosurg Psychiatry. 1999;  67 113-115
    PubMedSearch in Google Scholar
  • 10 Pascual-Leone A, Rubio B, Pallardó F, Catalá M D. Rapid-rate transcranial magnetic stimulation of left dorsolateral prefrontal cortex in drug-resistant depression.  Lancet. 1996;  348 233-237
    CrossrefPubMedSearch in Google Scholar
  • 11 Cordes J, Mobascher A, Arends M. et al . Ein neues Behandlungsverfahren der Depression: Die repetitive transcranielle Magnetstimulation (rTMS).  Dtsch Med Wochenschrift. 2005;  130 889-892
    Thieme ConnectPubMedSearch in Google Scholar
  • 12 Lefaucheur J P. Transcranial magnetic stimulation in the management of pain.  Suppl Clin Neurophysiol. 2004;  57 737-748
    PubMedSearch in Google Scholar
  • 13 Sampson S M, Rome J D, Rummans T A. Slow-frequency rTMS reduces fibromyalgia pain.  Pain Med. 2006;  7 115-118
    CrossrefPubMedSearch in Google Scholar
  • 14 Leo R J, Latif T. Repetitive transcranial magnetic stimulation (rTMS) in experimentally induced and chronic neuropathic pain: a review.  J Pain. 2007;  8 453-459
    CrossrefPubMedSearch in Google Scholar
  • 15 Saba G, Schurhoff F, Leboyer M. Therapeutic and neurophysiologic aspects of transcranial magnetic stimulation in schizophrenia.  Neurophysiol Clin. 2006;  36 185-194
    CrossrefPubMedSearch in Google Scholar
  • 16 Plewnia C, Bartels M, Gerloff C. Transient suppression of tinnitus by transcranial magnetic stimulation.  Ann Neurol. 2003;  53 263-266
    CrossrefPubMedSearch in Google Scholar
  • 17 De Ridder D, De Mulder G, Walsh V. et al . Magnetic and electrical stimulation of the auditory cortex for intractable tinnitus. Case report.  J Neurosurg. 2004;  100 560-564
    PubMedSearch in Google Scholar
  • 18 De Ridder D, Verstraeten E, Van der Kelen K. et al . Transcranial magnetic stimulation for tinnitus: influence of tinnitus duration on stimulation parameter choice and maximal tinnitus suppression.  Otol Neurotol. 2005;  26 616-619
    CrossrefPubMedSearch in Google Scholar
  • 19 Fregni F, Marcondes R, Boggio P S. et al . Transient tinnitus suppression induced by repetitive transcranial magnetic stimulation and transcranial direct current stimulation.  Eur J Neurol. 2006;  13 996-1001
    CrossrefPubMedSearch in Google Scholar
  • 20 Folmer R L, Carroll J R, Rahim A. et al . Effects of repetitive transcranial magnetic stimulation (rTMS) on chronic tinnitus.  Acta Otolaryngol Suppl. 2006;  126 96-101
    CrossrefPubMedSearch in Google Scholar
  • 21 Langguth B, Zowe M, Landgrebe M. et al . Transcranial magnetic stimulation for the treatment of tinnitus: a new coil positioning method and first results.  Brain Topography. 2006;  18 241-247
    CrossrefPubMedSearch in Google Scholar
  • 22 Eichhammer P, Langguth B, Marienhagen J. et al . Neuronavigated repetitive transcranial magnetic stimulation in patients with tinnitus: a short case series.  Biol Psychiatry. 2002;  54 862-865
    PubMedSearch in Google Scholar
  • 23 Langguth B, Eichhammer P, Wiegand R. et al . Neuronavigated rTMS in a patient with chronic tinnitus. Effects of a 4 weeks treatment.  Neuro Report. 2003;  14 977-980
    CrossrefPubMedSearch in Google Scholar
  • 24 Kleinjung T, Eichhammer P, Langguth B. et al . Long-term effects of repetitive transcranial magnetic stimulation (rTMS) in patients with chronic tinnitus.  Otolaryngol Head Neck Surg. 2005;  132 566-569
    CrossrefPubMedSearch in Google Scholar
  • 25 Richter G T, Mennemeier M, Bartel T. et al . Repetitive transcranial magnetic stimulation for tinnitus: a case study.  Laryngoscope. 2006;  116 1867-1872
    CrossrefPubMedSearch in Google Scholar
  • 26 Londero A, Langguth B, De Ridder D. et al . Repetitive transcranial magnetic stimulation (rTMS): A new therapeutic approach in subjective tinnitus?.  Neurophysiologie Clinique. 2006;  36 45-55
    PubMedSearch in Google Scholar
  • 27 Langguth B, Eichhammer P, Kreutzer A. et al . The impact of auditory cortex activity on characterizing and treating patients with chronic tinnitus-first results from a PET study.  Acta Otolaryngol Suppl. 2006;  126 84-88
    CrossrefPubMedSearch in Google Scholar
  • 28 Plewnia C, Reimold M, Najib A. et al . Dose-dependent attenuation of auditory phantom perception (tinnitus) by PET-guided repetitive transcranial magnetic stimulation.  Hum Brain Mapp. 2007;  28 238-246
    CrossrefPubMedSearch in Google Scholar
  • 29 Plewnia C, Reimold M, Najib A. et al . Moderate therapeutic efficacy of positron emission tomography-navigated repetitive transcranial magnetic stimulation for chronic tinnitus: a randomised, controlled pilot study.  J Neurol Neurosurg Psychiatry. 2007;  78 152-156
    CrossrefPubMedSearch in Google Scholar
  • 30 Rossi S, De Capua A, Ulivelli M. et al . Effects of repetitive transcranial magnetic stimulation on chronic tinnitus. A randomised, cross over, double blind, placebo-controlled study.  J Neurol Neurosurg Psychiatry. 2007;  78 857-863
    CrossrefPubMedSearch in Google Scholar
  • 31 Tsuji S. Clinical applications of transcranial magnetic stimulation for the treatment of various neurological diseases.  Rinsho Shinkeigaku. 2005;  11 831-833
    PubMedSearch in Google Scholar
  • 32 Khedr E M, Rothwell J C, Shawky O A. et al . Effect of daily repetitive transcranial magnetic stimulation on motor performance in Parkinson's disease.  Mov Disord. 2006;  21 2201-2205
    CrossrefPubMedSearch in Google Scholar
  • 33 Ellaway P H, Davey N J, Maskill D W, Dick J P. The relation between bradykinesia and excitability of the motor cortex assessed using transcranial magnetic stimulation in normal and parkinsonian subjects.  Electroencephalogr Clin Neurophysiol. 1995;  97 169-178
    CrossrefPubMedSearch in Google Scholar
  • 34 Mally J, Stone T W. Improvement in Parkinsonian symptoms after repetitive transcranial magnetic stimulation.  J Neurol Sci. 1999;  162 179-184
    CrossrefPubMedSearch in Google Scholar
  • 35 Mally J, Stone T W. Therapeutic and „dosedependent” effect of repetitive microelectroshock induced by transcranial magnetic stimulation in Parkinson's disease.  J Neurosci Res. 1999;  57 935-940
    CrossrefPubMedSearch in Google Scholar
  • 36 Pascual-Leone A, Valls-Solé J, Brasil-Neto J P. et al . Akinesia in Parkinson's disease. II. Effects of subthreshold repetitive transcranial motor cortex stimulation.  Neurology. 1994;  44 892-898
    PubMedSearch in Google Scholar
  • 37 Ridding M C, Inzelberg R, Rothwell J C. Changes in excitability of motor cortical circuitry in patients with Parkinson's disease.  Ann Neurol. 1995;  37 181-188
    CrossrefPubMedSearch in Google Scholar
  • 38 Siebner H R, Mentschel C, Auer C, Conrad B. Repetitive transcranial magnetic stimulation has a beneficial effect on bradykinesia in Parkinson's disease.  Neuroreport. 1999;  10 589-594
    PubMedSearch in Google Scholar
  • 39 Siebner H R, Tormos J M, Ceballos-Baumann A O. et al . Low-frequency repetitive transcranial magnetic stimulation of the motor cortex in writer's cramp.  Neurology. 1999;  52 529-537
    CrossrefPubMedSearch in Google Scholar
  • 40 Schrader L M, Stern J M, Koski L. et al . Seizure incidence during single- and paired-pulse transcranial magnetic stimulation (TMS) in individuals with epilepsy.  Clin Neurophysiol. 2004;  115 2728-2737
    CrossrefPubMedSearch in Google Scholar
  • 41 Bae E H, Schrader L M, Machii K. et al . Safety and tolerability of repetitive transcranial magnetic stimulation in patients with epilepsy: a review of the literature.  Epilepsy Behav. 2007;  10 521-528
    CrossrefPubMedSearch in Google Scholar
  • 42 Wassermann E M. Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the international workshop on the safety of rTMS.  Electroencephalogr Clin Neurophysiol. 1998;  108 1-16
    PubMedSearch in Google Scholar
  • 43 Rossini P M, Rossi S. Transcranial magnetic stimulation: diagnostic, therapeutic, and research potential.  Neurology. 2007;  68 484-488
    CrossrefPubMedSearch in Google Scholar
  • 44 Huang Y Z, Edwards M J, Rounis E. et al . Theta burst stimulation of the human motor cortex.  Neuron. 2005;  45 201-206
    CrossrefPubMedSearch in Google Scholar
  • 45 Thickbroom G W, Byrnes M L, Edwards D J, Mastaglia F L. Repetitive paired-pulse TMS at I-wave periodicity markedly increases corticospinal excitability: a new technique for modulating synaptic plasticity.  Clin Neurophysiol. 2006;  117 61-66
    CrossrefPubMedSearch in Google Scholar
  • 46 Lang N, Siebner H R, Ernst D. et al . Preconditioning with transcranial direct current stimulation sensitizes the motor cortex to rapid-rate transcranial magnetic stimulation and controls the direction of after-effects.  Biol Psychiatry. 2004;  56 634-639
    CrossrefPubMedSearch in Google Scholar
  • 47 Siebner H R, Lang N, Rizzo V. et al . Preconditioning of low-frequency repetitive transcranial magnetic stimulation with transcranial direct current stimulation: evidence for homeostatic plasticity in the human motor cortex.  J Neurosci. 2004;  24 3379-3385
    CrossrefPubMedSearch in Google Scholar
  • 48 Heller A J. Classification and epidemiology of tinnitus.  Otolaryngol Clin North Am. 2003;  36 239-248
    CrossrefPubMedSearch in Google Scholar
  • 49 Dobie R A. Depression and tinnitus.  Otolaryngol Clin North Am. 2003;  36 383-388
    CrossrefPubMedSearch in Google Scholar
  • 50 Guitton M J, Caston J, Ruel J. et al . Salicylate induces tinnitus through activation of cochlear NMDA receptors.  J Neurosci. 2003;  23 3944-3952
    PubMedSearch in Google Scholar
  • 51 Duan M, Agerman K, Ernfors P, Canlon B. Complementary roles of neurotrophin 3 and a N-methyl-D-aspartate antagonist in the protection of noise and aminoglycoside-induced ototoxicity.  Proc Natl Acad Sci USA. 2000;  97 7597-7602
    CrossrefPubMedSearch in Google Scholar
  • 52 Lenarz T, Schreiner C, Snyder R L, Ernst A. Neural mechanisms of tinnitus.  Eur Arch Otorhinolaryngol. 1993;  249 441-446
    PubMedSearch in Google Scholar
  • 53 Matthies C, Samii M. Management of 1000 vestibular schwannomas (acoustic neuromas): clinical presentation.  Neurosurgery. 1997;  40 1-9; discussion 9 - 10
    CrossrefPubMedSearch in Google Scholar
  • 54 Eggermont J J, Roberts L E. The neuroscience of tinnitus.  Trends Neurosci. 2004;  27 676-682
    CrossrefPubMedSearch in Google Scholar
  • 55 Muhlnickel W, Elbert T, Taub E, Flor H. Reorganization of auditory cortex in tinnitus.  Proc Natl Acad Sci USA. 1998;  95 10340-10343
    CrossrefPubMedSearch in Google Scholar
  • 56 Rajan R. Receptor organ damage causes loss of cortical surround inhibition without topographic map plasticity.  Nat Neurosci. 1998;  1 138-143
    CrossrefPubMedSearch in Google Scholar
  • 57 Rauschecker J P. Auditory cortical plasticity: a comparison with other sensory systems.  Trends Neurosci. 1999;  22 74-80
    CrossrefPubMedSearch in Google Scholar
  • 58 Moller A R. Similarities between severe tinnitus and chronic pain.  J Am Acad Audiol. 2000;  11 115-124
    PubMedSearch in Google Scholar
  • 59 Hoffman R E, Hawkins K A, Guerguieva R. et al . Transcranial magnetic stimulation of left temporoparietal cortex and medication-resistant auditory hallucinations.  Arch Gen Psych. 2003;  60 49-56
    CrossrefPubMedSearch in Google Scholar
  • 60 Goebel G, Hiller W. Tinnitus-Fragebogen (TF).  HNO. 1994;  42 166-172
    PubMedSearch in Google Scholar

Dr. Csaba Poreisz

Klinische Neurophysiologie, Georg-August-Universität

Robert-Koch-Straße 40

37077 Göttingen

Email: csaba.poreisz@med.uni-goettingen.de