Moderne Immuntherapie der multiplen Sklerose

Zusammenfassung

Wesentliche Fortschritte auf verschiedenen Gebieten der neuroimmunologischen Forschung haben im letzten Jahrzehnt zu einer deutlichen Erweiterung der zur Verfügung stehenden therapeutischen Möglichkeiten in der Behandlung der multiplen Sklerose geführt. Diese Fortschritte beinhalten ein verbessertes Verständnis zugrunde liegender pathogenetischer Veränderungen, biotechnologische Weiterentwicklungen, aber auch Fortentwicklungen in der Gestaltung klinischer Studien. In dieser Übersicht werden pathophysiologische Aspekte, klinische Rationale sowie die praktische Anwendung etablierter MS-Therapeutika diskutiert.

Abstract

Considerable progress in different fields of neuroimmunological research has led to a major increase in the therapeutic options available for the treatment of multiple sclerosis over the last decade. This progress not only includes advances in our understanding of the pathophysiology of MS, and biotechnological developments but also improvements in clinical trial design. Here, we will review pathophysiological aspects, clinical rationale and practical issues of current MS therapy.

Schlüsselwörter

multiple Sklerose - immunmodulatorische Therapie - Schubtherapie - Eskalationstherapie

Key words

multiple sclerosis - immunomodulatory therapy - relapse therapy - escalation therapy

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