Electrochemically Induced Aza-Henry Reaction: A New, Mild, and Clean Synthesis of α-Nitroamines

Leucio Rossi; Gabriele Bianchi; Marta Feroci; Achille Inesi

doi:10.1055/s-2007-986643

LETTER

Electrochemically Induced Aza-Henry Reaction: A New, Mild, and Clean Synthesis of α-Nitroamines

Leucio Rossi*^a, Gabriele Bianchi^a, Marta Feroci^b, Achille Inesi*^b
^a Dipartimento di Chimica, Ingegneria Chimica e Materiali, Universita degli Studi, 67040 L’Aquila, Italy
Fax: +39(0862)434203; e-Mail: rossil@ing.univaq.it;
^b Dipartimento ICMMPM, Università ‘La Sapienza’, Via C. Laurenziano 7, 00161 Roma, Italy

Abstract

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Abstract

The addition reaction of nitro compounds to azomethine functions, known as the aza-Henry (or nitro-Mannich) reaction was performed electrochemically under solvent and supporting electrolyte-free conditions. Reaction yields are very good and the method is very clean, avoiding the use of any classical solvent or catalyst.

Key words

carbanions - green chemistry - imines - Michael additions - nucleophilic additions

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References

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