Abstract
We report on a 33-year-old man who underwent an odyssey of doctors for investigation
of dysphagia. Eventually, a nasopharyngeal mass was found by several otorhinolaryngologists
who repeatedly recommended biopsy or excision, because a polyp or fibroma was assumed
on nasal endoscopy and MR imaging. However, we finally diagnosed the nasopharyngeal
mass to be an ectopic pituitary gland after thorough clinical (cleft lip and palate)
and radiological re-examination. Literally, the patient had a “good nose”, since he
refused manipulations on the nasopharyngeal tumour and assumably prevented inadvertent
hypopituitarism. We conclude that biopsy or excision of nasopharyngeal masses should
always be considered carefully, especially in patients with facial anomalies.
Key words
ectopic pituitary - incidentaloma - nasal polyp - hypopituitarism
References
- 1
Currarino G, Maravilla KR, Salyer KE.
Transsphenoidal canal (large craniopharyngeal canal) and its pathologic implications.
Am J Neuroradiol.
1985;
6
39-43
- 2
Das CJ, Seith A, Gamangagatti S, Goswami R.
Ectopic pituitary adenoma with an empty sella.
Am J Roentgenol.
2006;
186
1468-1472
- 3
Ekinci G, Kilic T, Baltacioglu F, Elmaci I, Altun E, Pamir MN, Erzen C.
Transsphenoidal (large craniopharyngeal) canal associated with a normally functioning
pituitary gland and nasopharyngeal extension, hyperprolactinemia, and hypothalamic
hamartoma.
Am J Roentgenol.
2003;
180
76-77
- 4
Hori A, Schmidt D, Kuebber S.
Immunohistochemical survey of migration of human anterior pituitary cells in developmental,
pathological, and clinical aspects: a review.
Microsc Res Tech.
1999;
46
59-68
- 5
Hori E, Akai T, Kurimoto M, Hirashima Y, Endo S.
Growth hormone-secreting pituitary adenoma confined to the sphenoid sinus associated
with a normal-sized empty sella.
J Clin Neurosci.
2002;
9
196-199
- 6
Hughes ML, Carty AT, White FE.
Persistent hypophyseal (craniopharyngeal) canal.
Br J Radiol.
1999;
72
204-206
- 7
Marsot-Dupuch K, Smoker WR, Grauer W.
A rare expression of neural crest disorders: an intrasphenoidal development of the
anterior pituitary gland.
Am J Neuroradiol.
2004;
25
285-288
- 8
Osman M, Allan JC, Kramer B.
A pharyngeal and ectopic hypophysis in a neonate with craniofacial abnormalities:
a case report and review of development and structure.
Cleft Palate Craniofac J.
2006;
43
117-122
- 9
Tweedie AR, Keith A.
Ectopia of the pituitary, with other congenital anomalies of the nose, palate and
upper lip.
J R Soc Med.
1910-1911;
5
47-54
- 10
Weber FT, Donnelly WH Jr, Bejar RL.
Hypopituitarism following extirpation of a pharyngeal pituitary.
Am J Dis Child.
1977;
131
525-528
Correspondence
Dr. L. Sze
Diabetes & Obesity Research Program
Garvan Institute of Medical Research
384 Victoria Street
Darlinghurst
Sydney
2010 NSW
Australia
Phone: +61/2/9295 82 14
Fax: +61/2/9295 84 81
Email: lisa.sze@bluewin.ch