ABSTRACT
Implantation is a complex event requiring synchronization between a developing embryo
and receptive endometrium. This process is governed by molecular mechanism mediated
by homeobox (Hox) genes, which encode transcription factors. These factors guide embryologic
development as well as regulate differential gene expression within the endometrium
with each menstrual cycle. Spatiotemporal aberrations in HOX gene expression as seen
with polycystic ovarian syndrome, endometriosis, hydrosalpinges, and endocrine disrupters
compromise implantation. The role of HOX genes and their products continues to be
explored as animal models that demonstrate implantation-specific infertile phenotypes
continue to be investigated.
KEYWORDS
HOX - implantation - endometrium - pregnancy
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Hugh S TaylorM.D.
Department of Obstetrics, Gynecology and Infertility, Yale University School of Medicine
333 Cedar Street, New Haven, CT 06520
Email: hugh.taylor@yale.edu
