Scirrhous gastric carcinoma is a diffusely infiltrating type of poorly differentiated
gastric carcinoma. It is characterized by cancer cell infiltration and proliferation
beneath the gastric mucosa with marked stromal fibrosis [1]. The gastric wall is thickened and stiffened due to diffuse infiltration and proliferation
of cancer cells with extensive stromal fibrosis. Endoscopy is useful for assessing
the growth pattern, but it is very difficult to obtain an appropriate sample with
a routine pinch biopsy. However, after utilizing argon plasma coagulation (APC) to
remove the superficial gastric epithelium and cauterize the denuded surface, we were
easily able to confirm the diagnosis of scirrhous gastric carcinoma with pinch biopsy.
A 79-year-old woman attended a clinic because of upper abdominal discomfort. Gastrointestinal
endoscopy strongly suggested the presence of advanced gastric cancer, but no cancer
cells were found in routine biopsy specimens. The patient was referred to our hospital
for definitive diagnosis and further treatment. At gastrointestinal endoscopy, the
stomach was very hard and could not be distended with air; it was covered with roughened
mucosa that was red and edematous, but no erosions or ulcerations were seen ([Fig. 1]). Biopsy was done again, but a histopathological diagnosis was not obtained.
Fig. 1 Endoscopic view of the stomach. The stomach was very rigid and could not be distended
with air; it was covered with roughened mucosa that was red and edematous. No erosions
or ulcerations were seen.
To obtain a definitive diagnosis, biopsy after APC treatment was utilized [2]. APC treatment included 50 W soft-mode coagulation and 0.5 L/min argon gas (ICC200;
Erbe Co., Tübingen, Germany). The first biopsy after APC treatment yielded a definite
histopathological diagnosis; cancer cells were observed beneath the APC-burned area
in the biopsied sample ([Fig. 2]). The cancer cells, clustered together, were small-sized, atypical cells that contained
PAS-positive material in their cytoplasm. On the basis of these findings, a definite
histopathological diagnosis of poorly differentiated adenocarcinoma was made.
Fig. 2 a Light micrograph of the biopsy specimen at low magnification (× 100). The margin
burned by APC treatment prior to the biopsy is seen on the right half of the figure.
The left half of the figure shows the undamaged tissue sample containing cancer cells.
b Light micrograph of biopsy specimen at high magnification (× 400). Poorly differentiated
adenocarcinoma cells with signet ring cells are clearly seen.
Endoscopy_UCTN_Code_TTT_1AO_2AC
