Semin Speech Lang 2008; 29(1): 044-059
DOI: 10.1055/s-2008-1061624
© Thieme Medical Publishers

In Search of Meaning: Reading and Writing in Alzheimer's Disease

Stacy M. Harnish1 , 3 , Jean Neils-Strunjas2 , 3
  • 1Doctoral candidate
  • 2Professor and Director of Graduate Studies, Department of Communication Sciences & Disorders, University of Cincinnati, Cincinnati, Ohio
  • 3Department of Communication Sciences & Disorders, University of Cincinnati, Cincinnati, Ohio
Further Information

Publication History

Publication Date:
28 April 2008 (online)

ABSTRACT

Decline in semantic memory is a key feature of Alzheimer's disease, and reading and writing performance reflects this loss. The article presents an overview of theoretical reading and spelling models, including definitions of key terminology and controversies surrounding the interaction of semantics and the orthographic lexicon. We review literature supporting a direct lexical nonsemantic route in reading and writing. The reading and writing deficits of Alzheimer's disease are contrasted with those of semantic dementia. Methods of assessing semantic memory in reading and writing are outlined, including administering published tests, word lists, homophones, written confrontation naming, verbal fluency, and written narrative analysis.

REFERENCES

  • 1 Neils J, Roeltgen D P, Constantinidou F. Decline in homophone spelling associated with loss of semantic influence on spelling in Alzheimer's disease.  Brain Lang. 1995;  49 27-49
  • 2 Noble K, Glosser G, Grossman M. Oral reading in dementia.  Brain Lang. 2000;  74 48-69
  • 3 Patterson K, Graham N, Hodges J. Reading in dementia of the Alzheimer's type: a preserved ability?.  Neuropsychology. 1994;  8 395-407
  • 4 Jefferies E, Lambon Ralph M A, Jones R, Bateman D, Patterson K. Surface dyslexia in semantic dementia: a comparison of the influence of consistency and regularity.  Neurocase. 2004;  10 290-299
  • 5 Kemper S, Greiner L H, Marquis J G, Prenovost K, Mitzner T L. Language decline across the life span: findings from the Nun Study.  Psychol Aging. 2001;  16 227-239
  • 6 Horner J, Heyman A, Dawson D, Rogers H. The relationship of agraphia to the severity of dementia in Alzheimer's disease.  Arch Neurol. 1988;  45 760-763
  • 7 Neils J, Boller F, Gerdeman B, Cole M. Descriptive writing abilities in Alzheimer's disease.  J Clin Exp Neuropsychol. 1989;  11 692-698
  • 8 Kavrie S, Neils-Strunjas J. Dysgraphia in Alzheimer's disease with mild cognitive impairment.  J Med Speech Lang Pathol. 2002;  10 73-85
  • 9 Coltheart M. Are there lexicons?.  Q J Exp Psychol A. 2004;  57 1153-1171
  • 10 Miceli G, Capasso R. Spelling and dysgraphia.  Cogn Neuropsychol. 2006;  23 110-134
  • 11 Coltheart M, Rastle K, Perry C, Langdon R, Ziegler J. DRC: a dual route cascaded model of visual word recognition and reading aloud.  Psychol Rev. 2001;  108 204-256
  • 12 Radvansky G A. Human Memory. Boston, MA; Pearson Allyn and Bacon 2006
  • 13 Saumier D, Chertkow H. Semantic memory.  Curr Neurol Neurosci Rep. 2002;  2 516-522
  • 14 Patterson K, Plaut D C, McClelland J L, Seidenberg M S, Behrmann M, Hodges J R. Connections and disconnections: a connectionist account of surface dyslexia. In: Reggia J, Berndt R, Ruppins E Neural Modeling of Cognitive and Brain Disorders. New York, NY; World Scientific 1996: 177-199
  • 15 Blazely A M, Coltheart M, Casey B J. Semantic impairment with and without surface dyslexia: implications for models of reading.  Cogn Neuropsychol. 2005;  22 695-717
  • 16 Weekes C, Coltheart M. Surface dyslexia and surface dysgraphia: treatment studies and their theoretical implications.  Cogn Neuropsychol. 1996;  13 277-315
  • 17 Neils-Strunjas J, Groves-Wright K, Mashima P, Harnish S. Dysgraphia in Alzheimer's disease: a review for clinical and research purposes.  J Speech Lang Hear Res. 2006;  49 1313-1330
  • 18 Colangelo A, Buchanan L, Westbury C. Deep dyslexia and semantic errors: a test of the failure of inhibition hypothesis using a semantic blocking paradigm.  Brain Cogn. 2004;  54 232-234
  • 19 Southwood M H, Chatterjee A. The interaction of multiple routes in oral reading: evidence from dissociations in naming and oral reading in phonological dyslexia.  Brain Lang. 2000;  72 14-39
  • 20 Crutch S J. Qualitatively different semantic representations for abstract and concrete words: further evidence from the semantic reading errors of deep dyslexic patients.  Neurocase. 2006;  12 91-97
  • 21 Plaut D C, McClelland J L, Seidenberg M S, Patterson K. Understanding normal and impaired word reading: computational principles in quasi-regular domains.  Psychol Rev. 1996;  103 56-115
  • 22 Shallice T. From Neuropsychology to Mental Structure. Cambridge, UK; Cambridge University Press 1988
  • 23 Coltheart M. Deep Dyslexia. London, UK; Routledge and Kegan Paul 1980
  • 24 Hillis A E, Rapp B C, Caramazza A. When a rose is a rose in speech but a tulip in writing.  Cortex. 1999;  35 337-356
  • 25 Spiro R J, Myers A. Individual differences and underlying cognitive processes in reading. In: Pearson PD, Barr R, Kamil M, Mosenthal P Handbook of Reading Research. Mahwah, NJ; Lawrence Erlbaum 2002: 471-501
  • 26 Strain E, Patterson K, Graham N, Hodges J R. Word reading in Alzheimer's disease: cross-sectional and longitudinal analyses of response time and accuracy data.  Neuropsychologia. 1998;  36 155-171
  • 27 Ober B A, Shenaut G K. Semantic Memory. In: Traxler MJ, Gernsbacher MA Handbook of Psycholinguistics. 2nd ed. Amsterdam, The Netherlands; Elsevier 2006: 403-454
  • 28 Reilly J, Grossman M. Language processing in dementia. In: Budson A, Kowell N Alzheimer's Disease and Associated Disorders. Edinburgh, Scotland; Blackwell Synergy Press In Press
  • 29 Camus J F, Nicolas S, Wenisch E, Morrone I, Blanchard F, Bakchine S. Implicit memory for words presented in short texts is preserved in Alzheimer's disease.  Psychol Med. 2003;  33 169-174
  • 30 Altmann L J, McClung J S. Effects of semantic impairment on language use in Alzheimer disease.  Semin Speech Lang. 2008;  29 xx
  • 31 Giffard B, Desgranges B, Eustache F. Semantic memory disorders in Alzheimer's disease: clues from semantic priming effects.  Curr Alzheimer Res. 2005;  2 425-434
  • 32 Rapcsak S Z, Henry M L, Teague S L, Carnahan S D, Beeson P M. Do dual-route models accurately predict reading and spelling performance in individuals with acquired alexia and agraphia?.  Neuropsychologia. 2007;  45 2519-2524
  • 33 Raymer A M, Berndt R S. Reading lexically without semantics: evidence from patients with probable Alzheimer's disease.  J Int Neuropsychol Soc. 1996;  2 340-349
  • 34 Mechelli A, Crinion J T, Long S et al.. Dissociating reading processes on the basis of neuronal interactions.  J Cogn Neurosci. 2005;  17 1753-1765
  • 35 Hillis A E, Caramazza A. Mechanisms for accessing lexical representations for output: evidence from a category-specific semantic deficit.  Brain Lang. 1991;  40 106-144
  • 36 Lambon Ralph M A, Ellis A W, Franklin S. Semantic loss without surface dyslexia.  Neurocase. 1995;  1 363-369
  • 37 Perry C, Ziegler J, Zorzi M. Nested incremental modeling in the development of computational theories: the CDP + model of reading aloud.  Psychol Rev. 2007;  114 273-315
  • 38 Coltheart M. Acquired dyslexias and the computational modelling of reading.  Cogn Neuropsychol. 2006;  23 96-109
  • 39 Hodges J R, Graham K S. Episodic memory: insights from semantic dementia.  Philos Trans R Soc Lond B Biol Sci. 2001;  356 1423-1434
  • 40 Lovden M, Ronnlund M, Wahlin A, Backman L, Nyberg L, Nilsson L. The extent of stability and change in episodic and semantic memory in old age: demographic predictors of level and change.  J Gerontol B Psychol Sci Soc Sci. 2004;  59B 130-134
  • 41 Salmon D P, Butters N, Chan A S. The deterioration of semantic memory in Alzheimer's disease.  Can J Exp Psychol. 1999;  53 108-117
  • 42 Howard D, Patterson K. Pyramids and Palm Trees: A Test of Semantic Access from Pictures and Words. Bury St. Edmunds, UK; Thames Valley Test Co 1992
  • 43 Kay J, Lesser R, Coltheart M. PALPA: Psycholinguistic Assessments of Language Processing in Aphasia. London; Lawrence Erlbaum Associates 1992
  • 44 LaPointe L L, Horner J. Reading Comprehension Battery for Aphasia (RCBA-2). 2nd ed. Austin, TX; PRO-ED 1998
  • 45 Blair J R, Spreen O. Predicting premorbid IQ: A revision of the National Reading Test.  The Clinical Neuropsychologist. 1989;  3 129-136
  • 46 Goodman R A, Caramazza A. The Johns Hopkins Dyslexia Battery. Baltimore, MD; Johns Hopkins University Press 1986
  • 47 Beeson P, Hillis A E. Comprehension and production of written words. In: Chapey R Language Intervention Strategies in Adult Aphasia. 4th ed. Baltimore, MD; Lippincott Williams & Wilkins 2001
  • 48 Heilman K M, Doty L, Stewart J T, Bowers D, Gonzalez-Rothi L. Helping People with Progressive Memory Disorders: A Guide for You and Your Family. 2nd ed. Gainesville, FL; University of Florida Press 1999
  • 49 Sabe L, Jason L, Juejati M, Leiguarda R, Starkstein S E. Dissociation between declarative and procedural learning in dementia and depression.  J Clin Exp Neuropsychol. 1995;  17 841-848
  • 50 Groves-Wright K, Neils-Strunjas J, Burnett R, O'Neill M J. A comparison of verbal and written language in Alzheimer's disease.  J Commun Disord. 2004;  37 109-130
  • 51 Neils-Strunjas J, Shuren J, Roeltgen D, Brown C. Perseverative writing errors in a patient with Alzheimer's disease.  Brain Lang. 1998;  63 303-320
  • 52 Forbes K E, Shanks M F, Venneri A. The evolution of dysgraphia in Alzheimer's Disease.  Brain Res Bull. 2004;  63 19-24
  • 53 Silveri M C, Corda F, Di Nardo M. Central and peripheral aspects of writing disorders in Alzheimer's disease.  J Clin Exp Neuropsychol. 2007;  29 179-186
  • 54 Neils J, Roeltgen D. Does lexical dysgraphia occur in early Alzheimer's disease?.  J Med Speech-Lang Pathol. 1994;  2 281-289
  • 55 Roeltgen D. Agraphia. In: Heilman KM, Valenstein E Clinical Neuropsychology. 3rd ed. New York, NY; Oxford University Press 1993: 63-89
  • 56 Croisile B, Brabant M J, Carmoi T, Lepage Y, Aimard G, Trillet M. Comparison between oral and written spelling in Alzheimer's disease.  Brain Lang. 1996;  54 361-387
  • 57 Folstein M F, Folstein S E, McHugh P. Mini-mental state: A practical method for grading the cognitive state of patients for the clinician.  Journal of Psychiatric Research. 1975;  12 189-198
  • 58 Kaplan E, Goodglass H, Weintraub S. Boston Naming Test. 2nd ed. Philadelphia, PA; Lea & Febiger 1983
  • 59 Paul R H, Cohen R A, Williams L M et al.. Category and letter verbal fluency across the adult lifespan: relationship to EEG theta power.  Arch Clin Neuropsychol. 2005;  20 561-573
  • 60 Adlam A L, Bozeat S, Arnold R, Watson P, Hodges J R. Semantic knowledge in mild cognitive impairment and mild Alzheimer's disease.  Cortex. 2006;  42 675-684
  • 61 Rapcsak S Z, Arthur S A, Bliklen D A, Rubens A B. Lexical agraphia in Alzheimer's disease.  Arch Neurol. 1989;  46 65-68
  • 62 Hughes J C, Graham N, Patterson K, Hodges J R. Dysgraphia in mild dementia of Alzheimer's type.  Neuropsychologia. 1997;  35 533-545
  • 63 Platel H, Lambert J, Eustache F et al.. Characteristics and evolution of writing impairment in Alzheimer's disease.  Neuropsychologia. 1993;  31 1147-1158
  • 64 Pestell S, Shanks M F, Warrington J, Venneri A. Quality of spelling breakdown in Alzheimer's disease is independent of disease progression.  J Clin Exp Neuropsychol. 2000;  22 599-612
  • 65 Luzzatti C, Laiacona M, Agazzi D. Multiple patterns of writing disorders in dementia of the Alzheimer type and their evolution.  Neuropsychologia. 2003;  41 759-772
  • 66 Croisile B, Ska B, Brabant M J et al.. Comparative study of oral and written picture description in patients with Alzheimer's disease.  Brain Lang. 1996;  53 1-19
  • 67 Garrard P, Maloney L M, Hodges J R, Patterson K. The effects of very early Alzheimer's disease on the characteristics of writing by a renowned author.  Brain. 2005;  128 250-260
  • 68 Goodglass H, Kaplan E. The Assessment of Aphasia and Related Disorders. Philadelphia, PA; Lea & Febiger 1972
  • 69 Kertesz A. Western Aphasia Battery. New York; Grune & Stratton 1982
  • 70 Bayles K A, Kaszniak A W. Communication and Cognition in Normal Aging and Dementia. Boston, MA; College Hill/Little Brown and Co. 1987
  • 71 Goodglass H, Kaplan E. The Assessment of Aphasia and Related Disorders. 3rd ed. Philadelphia, PA; Lea & Febiger 2000
  • 72 Huff F J, Collins C, Corkin S, Rosen T J. Equivalent forms of the Boston Naming Test.  J Clin Exp Neuropsychol. 1986;  8 556-562

Jean Neils-StrunjasPh.D. 

Department of Communication Sciences & Disorders, University of Cincinnati

P.O. Box 670379, Cincinnati, OH 45267-0379

Email: neilsjr@ucmail.uc.edu

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