Periodontal disease, but not edentulism, is independently associated with increased plasma fibrinogen levels

Christian Schwahn; Henry Völzke; Daniel M. Robinson; Jan Luedemann; Olaf Bernhardt; Dietmar Gesch; Ulrich John; Thomas Kocher

doi:10.1160/TH04-02-0092

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2004; 92(02): 244-252
DOI: 10.1160/TH04-02-0092

Theme Issue Article

Schattauer GmbH

Periodontal disease, but not edentulism, is independently associated with increased plasma fibrinogen levels

Results from a population-based study

Christian Schwahn

¹School of Dentistry, Ernst-Moritz-Arndt-University, Greifswald, Germany

,

Henry Völzke

²Institute of Epidemiology and Social Medicine, Ernst-Moritz-Arndt-University, Greifswald, Germany

,

Daniel M. Robinson

³Department of Internal Medicine B, Ernst-Moritz-Arndt-University, Greifswald, Germany

,

Jan Luedemann

⁴Institute of Clinical Chemistry and Laborartory Medicine, Ernst-Moritz-Arndt-University, Greifswald, Germany

,

Olaf Bernhardt

¹School of Dentistry, Ernst-Moritz-Arndt-University, Greifswald, Germany

,

Dietmar Gesch

¹School of Dentistry, Ernst-Moritz-Arndt-University, Greifswald, Germany

,

Ulrich John

²Institute of Epidemiology and Social Medicine, Ernst-Moritz-Arndt-University, Greifswald, Germany

,

Thomas Kocher

¹School of Dentistry, Ernst-Moritz-Arndt-University, Greifswald, Germany

› Author Affiliations

Abstract

Summary

The systemic response to periodontal disease was analyzed in the cross-sectional Study of Health in Pomerania (SHIP). The completed data of 2,738 subjects aged 20 to 59 years were used for logistic regression analysis with an increased plasma fibrinogen level (≥3.25 g/L according to Clauss) as the dependent variable. Participants were divided into four groups according to the number of periodontal pockets ≥ 4mm (0, 1-7, 8-14, ≥15 pocketing). An additional group comprised the 52 edentulous subjects. The adjusted odds ratio (OR) of ≥15 periodontal pockets for increased plasma fibrinogen levels was 1.88 (95% CI: 1.25-2.83). Edentulism per se was not associated with increased plasma fibrinogen levels but was contained in a two-way interaction with the number of cigarettes/day in current smokers (p = 0.031). For edentulous nonsmokers the adjusted OR was 1.10 (95% CI: 0.51-2.39). Furthermore, body mass index, the interaction between gender and body mass index, serum LDL cholesterol, medication, the interaction between LDL cholesterol and medication, aspirin, smoking, school education, chronic bronchitis, and the interaction between alcohol consumption and chronic gastritis were associated with plasma fibrinogen levels. Our results show that periodontal disease but not edentulism per se is associated with an increased plasma fibrinogen level.

Keywords

Fibrinogen - periodontal disease - Study of Health in Pomerania - SHIP

Full Text

References

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