Identifying Complementary and Alternative Medicine Usage Information from Internet Resources

Vivekanand Sharma; John H. Holmes; Indra N. Sarkar

doi:10.3414/ME15-01-0154

Methods of Information in Medicine, Table of Contents

Methods Inf Med 2016; 55(04): 322-332
DOI: 10.3414/ME15-01-0154

Original Articles

Schattauer GmbH

Identifying Complementary and Alternative Medicine Usage Information from Internet Resources

A Systematic Review

Authors

Vivekanand Sharma

¹Center for Biomedical Informatics, Brown University, Providence, RI, USA
John H. Holmes

²Institute for Biomedical Informatics and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA
Indra N. Sarkar

¹Center for Biomedical Informatics, Brown University, Providence, RI, USA

Abstract

Summary

Objectives: Identify and highlight research issues and methods used in studying Complementary and Alternative Medicine (CAM) information needs, access, and exchange over the Internet.

Methods: A literature search was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines from PubMed to identify articles that have studied Internet use in the CAM context. Additional searches were conducted at Nature.com and Google Scholar.

Results: The Internet provides a major medium for attaining CAM information and can also serve as an avenue for conducting CAM related surveys. Based on the literature analyzed in this review, there seems to be significant interest in developing methodologies for identifying CAM treatments, including the analysis of search query data and social media platform discussions. Several studies have also underscored the challenges in developing approaches for identifying the reliability of CAM-related information on the Internet, which may not be supported with reliable sources. The overall findings of this review suggest that there are opportunities for developing approaches for making available accurate information and developing ways to restrict the spread and sale of potentially harmful CAM products and information.

Conclusions: Advances in Internet research are yet to be used in context of understanding CAM prevalence and perspectives. Such approaches may provide valuable insights into the current trends and needs in context of CAM use and spread.

Keywords

Internet - complementary therapies - informatics

Full Text

References

References
1 Internet User Over Time: Pew Research Center. [cited 2015 Feb 4]. Available from: http://www.pewinternet.org/data-trend/internet-use/internet-use-over-time.
2 Social Media Use Over Time: Pew Research Center. [cited 2015 Feb 4]. Available from: http://www.pewinternet.org/data-trend/social-media/social-media-use-all-users.
3 Fox S, Duggan M. Health Online 2013: Pew Internet & American Life Project. 2013 [updated Feb 4, 2015]. Available from: http://www.pewinternet.org/2013/01/15/health-online-2013/.
4 Goldstein MS. The persistence and resurgence of medical pluralism. J Health Polit Policy Law 2004; 29 (4–5) 925-45 discussion 1005–19.
5 Hardey M. Doctor in the house: the Internet as a source of lay health knowledge and the challenge to expertise. Sociol Health Ill 1999; 21 (Suppl. 06) 820-35.
6 Pitts V. Illness and Internet empowerment: writing and reading breast cancer in cyberspace. Health 2004; 8 (Suppl. 01) 33-59.
7 Radin P. “To me, it’s my life“: Medical communication, trust, and activism in cyberspace. Soc Sci Med 2006; 62 (Suppl. 03) 591-601.
8 Sharf BF. Communicating breast cancer on-line: Support and empowerment on the Internet. Women Health 1997; 26 (Suppl. 01) 65-84.
9 Maggini V, Gallo E, Vannacci A, Gori L, Mugelli A, Firenzuoli F. e-Phytovigilance for misleading herbal information. Trends Pharmacol Sci 2013; 34 (Suppl. 11) 594-5.
10 McGregor F, Somner JE, Bourne RR, Munn-Giddings C, Shah P, Cross V. Social media use by patients with glaucoma: what can we learn?. Ophthalmic Physiol Opt 2014; 34 (Suppl. 01) 46-52.
11 Molassiotis A, Xu M. Quality and safety issues of web-based information about herbal medicines in the treatment of cancer. Complement Ther Med 2004; 12 (Suppl. 04) 217-27.
12 Reddi A. Health information and the like. Science 2013; 342 (6164) 1315.
13 Campbell E, Salathe M. Complex social contagion makes networks more vulnerable to disease outbreaks. Sci Rep 2013; 3: 1905.
14 Muchnik L, Aral S, Taylor SJ. Social influence bias: a randomized experiment. Science 2013; 341 (6146) 647-51.
15 Broom A. Virtually healthy: The impact of Internet use on disease experience and the doctor-patient relationship. Qual Health Res 2005; 15 (Suppl. 03) 325-45.
16 Broom A, Tovey P. The role of the Internet in cancer patients’ engagement with complementary and alternative treatments. Health (London) 2008; 12 (Suppl. 02) 139-55.
17 Elsner T, Muecke R, Micke O, Prott FJ, Muenstedt K, Waldmann A, Geissler J, Huebner J. Survey on the worldwide Chronic Myeloid Leukemia Advocates Network regarding complementary and alternative medicine. J Cancer Res Clin Oncol 2013; 139 (Suppl. 06) 1025-31.
18 Paul M, Davey B, Senf B, Stoll C, Munstedt K, Mucke R, Micke O, Prott FJ, Buentzel J, Hubner J. Patients with advanced cancer and their usage of complementary and alternative medicine. J Cancer Res Clin Oncol 2013; 139 (Suppl. 09) 1515-22.
19 Musaiger AO, Abahussain NA. Attitudes and practices of complementary and alternative medicine among adolescents in Saudi Arabia. Glob J Health Sci 2015; 7 (Suppl. 01) 173-9.
20 Fox S, Duggan M. Alternative treatments or medicines: Pew Internet & American Life Project. 2009 [cited 2015 Feb 4]. Available from: http://www.pewinternet.org/2009/06/11/alternative-treatments-or-medicines.
21 Brijnath B, Antoniades J, Adams J. Investigating Patient Perspectives on Medical Returns and Buying Medicines Online in Two Communities in Melbourne, Australia: Results from a Qualitative Study. The Patient. 2014
22 Miron-Shatz T, Hansen MM, Grajales FJ, 3rd Martin-Sanchez F, Bamidis PD. Social Media for the Promotion of Holistic Self-Participatory Care: An Evidence Based Approach. Contribution of the IMIA Social Media Working Group. Yearb Med Inform 2013; 8 (Suppl. 01) 162-8.
23 Keshet Y. Network gatekeeping: complementary medicine information on the websites of medical institutions. Health (London) 2012; 16 (Suppl. 02) 151-68.
24 Sagaram S, Walji M, Bernstam E. Evaluating the prevalence, content and readability of complementary and alternative medicine (CAM) web pages on the internet. Proceedings / AMIA Annual Symposium AMIA Symposium 2002; 672-6.
25 Ernst E, Schmidt K. ‘Alternative’ cures for depression – how safe are web sites?. Psychiat Res 2004; 129 (Suppl. 03) 297-301.
26 Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med 2009; 6 (Suppl. 07) e1000100.
27 Braun V, Clarke V. Using thematic analysis in psychology. Qualitative Research in Psychology 2006; 3 (Suppl. 02) 77-101.
28 Huebner J, Prott FJ, Micke O, Muecke R, Senf B, Dennert G, Muenstedt K. Prio Online survey of cancer patients on complementary and alternative medicine. Oncol Res Treat 2014; 37 (Suppl. 06) 304-8.
29 Shaeer O, Shaeer K. The Global Online Sexuality Survey (GOSS): Erectile Dysfunction Among Arabic-Speaking Internet Users in the Middle East. J Sex Med 2011; 8 (Suppl. 08) 2152-63.
30 Chisolm DJ. Does Online Health Information Seeking Act Like a Health Behavior?: A Test of the Behavioral Model. Telemed J E-Health 2010; 16 (Suppl. 02) 155-61.
31 Ebel MD, Rudolph I, Keinki C, Hoppe A, Muecke R, Micke O, Muenstedt K, Huebner J. Perception of cancer patients of their disease, self-efficacy and locus of control and usage of complementary and alternative medicine. J Cancer Res Clin Oncol 2015; 141 (Suppl. 08) 1449-55.
32 D’arena G, Laurenti L, Coscia M, Cortelezzi A, Chiarenza A, Pozzato G, Vigliotti ML, Nunziata G, Fragasso A, Villa MR, Grossi A, Selleri C, Deaglio S, La Sala A, Del Poeta G, Simeon V, Aliberti L, De Martino L, Giudice A, Musto P, De Feo V. Complementary and alternative medicine use in patients with chronic lymphocytic leukemia: an Italian multicentric survey. Leuk Lymphoma 2014; 55 (Suppl. 04) 841-7.
33 Bussing R, Zima BT, Gary FA, Garvan CW. Use of complementary and alternative medicine for symptoms of attention-deficit hyperactivity disorder. Psychiatr Serv 2002; 53 (Suppl. 09) 1096-102.
34 Xie B, Wang M, Feldman R, Zhou L. Internet Use Frequency and Patient-Centered Care: Measuring Patient Preferences for Participation Using the Health Information Wants Questionnaire. J Med Internet Res 2013; 15 (Suppl. 07) 140-56.
35 Walsh MC, Trentham-Dietz A, Schroepfer TA, Reding DJ, Campbell B, Foote ML, Kaufman S, Barrett M, Remington PL, Cleary JF. Cancer Information Sources Used by Patients to Inform and Influence Treatment Decisions. J Health Commun 2010; 15 (Suppl. 04) 445-63.
36 Markowitz JE, Mamula P, delRosario JF, Baldassano RN, Lewis JD, Jawad AF, Culton K, Strom BL. Patterns of complementary and alternative medicine use in a population of pediatric patients with inflammatory bowel disease. Inflamm Bowel Dis 2004; 10 (Suppl. 05) 599-605.
37 Bruce B, Lorig K, Laurent D, Ritter P. The impact of a moderated e-mail discussion group on use of complementary and alternative therapies in subjects with recurrent back pain. Patient Educ Couns 2005; 58 (Suppl. 03) 305-11.
38 Curtis B, Alanis-Hirsch K, Kaynak Ö, Cacciola J, Meyers K, McLellan AT. Using Web searches to track interest in synthetic cannabinoids (aka ‘herbal incense’). Drug Alcohol Rev 2015; 34 (Suppl. 01) 105-8.
39 Hill S, Mao J, Ungar L, Hennessy S, Leonard CE, Holmes J. Natural Supplements for H1N1 Influenza: Retrospective Observational Infodemiology Study of Information and Search Activity on the Internet. J Med Internet Res 2011; 13 (Suppl. 02) e36.
40 Fung IC, Hao Y, Cai J, Ying Y, Schaible BJ, Yu CM, Tse ZT, Fu KW. Chinese Social Media Reaction to Information about 42 Notifiable Infectious Diseases. PLoS One 2015; 10 (Suppl. 05) e0126092.
41 Flower A, Bishop FL, Lewith G. How women manage recurrent urinary tract infections: an analysis of postings on a popular web forum. BMC Fam Pract 2014; 15: 162.
42 Alsawaf MA, Jatoi A. Shopping for nutrition-based complementary and alternative medicine on the internet: How much money might cancer patients be spending online?. J Cancer Educ 2007; 22 (Suppl. 03) 174-6.
43 Owen JE, Boxley L, Goldstein MS, Lee JH, Breen N, Rowland JH. Use of Health-Related Online Support Groups: Population Data from the California Health Interview Survey Complementary and Alternative Medicine Study. J Comput-Mediat Comm 2010; 15 (Suppl. 03) 427-46.
44 Pfeil U, Zaphiris P. Applying qualitative content analysis to study online support communities. Universal Access Inf 2010; 9 (Suppl. 01) 1-16.
45 Mursch K, Behnke-Mursch J. Internet-based interaction among brain tumour patients. Analysis of a medical mailing list. Zbl Neurochir 2003; 64 (Suppl. 02) 71-5.
46 Culver JD, Gerr F, Frumkin H. Medical information on the Internet – A study of an electronic bulletin board. J Gen Intern Med 1997; 12 (Suppl. 08) 466-70.
47 Smith CA, Wicks PJ. PatientsLikeMe: Consumer health vocabulary as a folksonomy. AMIA Annual Symposium proceedings / AMIA Symposium 2008; 682-6.
48 Kim J, Joo J, Shin Y. An exploratory study on the health information terms for the development of the consumer health vocabulary system. Stud Health Technol Inform 2009; 146: 785.
49 Gupta S, MacLean DL, Heer J, Manning CD. Induced lexico-syntactic patterns improve information extraction from online medical forums. J Am Med Inform Assoc 2014; 21 (Suppl. 05) 902-9.
50 Suarez-Almazor ME, Kendall CJ, Dorgan M. Surfing the Net – Information on the World Wide Web for persons with arthritis: Patient empowerment or patient deceit?. J Rheumatol 2001; 28 (Suppl. 01) 185-91.
51 Borzekowski DLG, Rickert VI. Adolescent cybersurfing for health information – A new resource that crosses barriers. Arch Pediat Adol Med 2001; 155 (Suppl. 07) 813-7.
52 Koh HL, Teo HH, Ng HL. Pharmacists’ patterns of use, knowledge, and attitudes toward complementary and alternative medicine. J Altern Complem Med 2003; 9 (Suppl. 01) 51-63.
53 Koo M. Complementary and Alternative Medicine on Wikipedia: Opportunities for Improvement. Evid-Based Compl Alt. 2014
54 Hubner J, Munstedt K, Micke O, Senf B. Information on complementary and alternative medicine at homepages of German cancer self-help. Deut Med Wochenschr 2013; 138 (1–2) 17-22.
55 Price A, Grann VR. Portrayal of Complementary and Alternative Medicine for Cancer by Top Online News Sites. J Altern Complem Med 2012; 18 (Suppl. 05) 487-93.
56 Keykhaie Z, Zareban I, Shahrakipoor M, Hormozi M, Sharifi-Rad J, Masoudi G, Rahimi F. Implementation of internet training on posture reform of computer users in iran. Acta Inform Med 2014; 22 (Suppl. 06) 379-84.
57 Narayanaswami P, Gronseth G, Dubinsky R, Pen-fold-Murray R, Cox J, Bever Jr. C, Martins Y, Rheaume C, Shouse D, Getchius TS. The Impact of Social Media on Dissemination and Implementation of Clinical Practice Guidelines: A Longitudinal Observational Study. J Med Internet Res 2015; 17 (Suppl. 08) e193.
58 Shon J, Marshall J, Musen MA. The impact of displayed awards on the credibility and retention of Web site information. Proceedings / AMIA Annual Symposium AMIA Symposium 2000; 794-8.
59 Ernst E, Schmidt K. ‘Alternative’ cancer cures via the Internet?. Brit J Cancer 2002; 87 (Suppl. 05) 479-80.
60 Molassiotis A, Xu M. Quality and safety issues of web-based information about herbal medicines in the treatment of cancer. Complement Ther Med 2004; 12 (Suppl. 04) 217-27.
61 Schmidt K, Ernst E. Assessing websites on complementary and alternative medicine for cancer. Ann Oncol 2004; 15 (Suppl. 05) 733-42.
62 Corazza O, Martinotti G, Santacroce R, Chillemi E, Di Giannantonio M, Schifano F, Cellek S. Sexual Enhancement Products for Sale Online: Raising Awareness of the Psychoactive Effects of Yohimbine, Maca, Horny Goat Weed, and Ginkgo biloba. Biomed Res Int. 2014
63 Owens C, Baergen R, Puckett D. Online Sources of Herbal Product Information. Am J Med 2014; 127 (Suppl. 02) 109-15.
64 Minervini L, Romanini FA, Solmi M, Passamani A, Sferrazza E, Schifono F. Acute Psychotic Episode Associated with the Intake of a TestosteroneEnhancer Herbal Mixture Purchased Online. Psychother Psychosom 2012; 81 (Suppl. 04) 248-9.
65 Ozdemir B, Sahin I, Kapucu H, Celbis O, Karakoc Y, Erdogan S, Onal Y. How safe is the use of herbal weight-loss products sold over the Internet?. Hum Exp Toxicol 2013; 32 (Suppl. 01) 101-6.
66 Cienki JJ, Zaret L. An Internet Misadventure: Bloodroot Salve Toxicity. J Altern Complem Med 2010; 16 (Suppl. 10) 1125-7.
67 Hillebrand J, Olszewski D, Sedefov R. Legal Highs on the Internet. Subst Use Misuse 2010; 45 (Suppl. 03) 330-40.
68 Muller D, Weinmann W, Hermanns-Clausen M. Chinese Slimming Capsules Containing Sibutra-mine Sold Over the Internet A Case Series. Dtsch Arztebl Int 2009; 106 (Suppl. 13) 218-U17.
69 Pauzé DK, Brooks DE. Lithium toxicity from an Internet dietary supplement. J Med Toxicol 2007; Jun 3 (Suppl. 02) 61-2.
70 Ashar BH, Miller RG, Getz KJ, Pichard CP. A critical evaluation of Internet marketing of products that contain ephedra. Mayo Clin Proc 2003; 78 (Suppl. 08) 944-6.
71 Black M, Hussain H. Hydrazine, cancer, the internet, isoniazid, and the liver. Ann Intern Med 2000; 133 (Suppl. 11) 911-3.
72 Dennehy CE, Tsourounis C, Miller AE. Evaluation of herbal dietary supplements marketed on the internet for recreational use. Ann Pharmacother 2005; 39 (Suppl. 10) 1634-9.
73 Gold LS, Slone TH. Aristolochic acid, an herbal carcinogen, sold on the Web after FDA alert. New Engl J Med 2003; 349 (Suppl. 16) 1576-7.
74 Haard J, Slater MD, Long M. Scientese and ambiguous citations in the selling of unproven medical treatments. Health Commun 2004; 16 (Suppl. 04) 411-26.
75 Jordan MA, Haywood T. Evaluation of internet websites marketing herbal weight-loss supplements to consumers. J Altern Complem Med 2007; 13 (Suppl. 09) 1035-43.
76 Nguyen MH, Ormiston T, Kurani S, Woo DK. Amphetamine lacing of an Internet-marketed neutraceutical. Mayo Clin Proc 2006; 81 (Suppl. 12) 1627-9.
77 Ross K. Crackdown on unproven cancer treatments focuses on Internet marketers. J Natl Cancer I 2008; 100 (Suppl. 17) 1200-U6.
78 Saper RB, Phillips RS, Sehgal A, Khouri N, Davis RB, Paquin J, Thuppil V, Kales SN. Lead, mercury, and arsenic in US- and Indian-manufactured Ayurvedic medicines sold via the Internet. JAMA 2008; 300 (Suppl. 08) 915-23. Erratum in: JAMA 2008; 300(14): 1652.
79 Kim JE, Lee YB, Lee JH, Kim HS, Lee KH, Park YM, Cho SH, Lee JY. Disease awareness and management behavior of patients with atopic dermatitis: a questionnaire survey of 313 patients. Ann Dermatol 2015; 27 (Suppl. 01) 40-7.
80 Morris CA, Avorn J. Internet marketing of herbal products. JAMA 2003; 290 (Suppl. 11) 1505-9.
81 Oleson TD. Herbal medicine online. J Altern Complement Med 2003; 9 (Suppl. 04) 581-4.
82 Matthews SC, Camacho A, Mills PJ, Dimsdale JE. The Internet for medical information about cancer: Help or hindrance?. Psychosomatics 2003; 44 (Suppl. 02) 100-3.
83 Cooke A, Gray L. Evaluating the quality of Internet-based information about alternative therapies: development of the BIOME guidelines. J Public Health Med 2002; 24 (Suppl. 04) 261-7.
84 Gunasekera V, Ernst E, Ezra DG. Systematic internet-based review of complementary and alternative medicine for glaucoma. Ophthalmology 2008; 115 (Suppl. 03) 435-9e2.
85 Charnock D, Shepperd S, Needham G, Gann R. DISCERN: an instrument for judging the quality of written consumer health information on treatment choices. J Epidemiol Community Health 1999; 53 (Suppl. 02) 105-11.
86 Silberg WM, Lundberg GD, Musacchio RA. Assessing, controlling, and assuring the quality of medical information on the Internet: Caveant lector et viewor – Let the reader and viewer beware. JAMA 1997; 277 (Suppl. 15) 1244-5.
87 Boyer C, Baujard V, Geissbuhler A. Evolution of health web certification through the HONcode experience. Stud Health Technol Inform 2011; 169: 53-7.
88 Hirasawa R, Saito K, Yachi Y, Ibe Y, Kodama S, Asumi M, Horikawa C, Saito A, Heianza Y, Kondo K, Shimano H, Sone H. Quality of Internet information related to the Mediterranean diet. Public Health Nutr 2012; 15 (Suppl. 05) 885-93.
89 Thakor V, Leach MJ, Gillham D, Esterman A. The quality of information on websites selling St. John’s wort. Complement Ther Med 2011; 19 (Suppl. 03) 155-60.
90 Tuna S, Dizdar O, Calis M. The prevalence of usage of herbal medicines among cancer patients. J Buon 2013; 18 (Suppl. 04) 1048-51.
91 Deng GE, Cassileth BR, Cohen L, Gubili J, Johnstone PAS, Kumar N, Vickers A. Integrative Oncology Practice Guidelines. J Soc Integr Oncol 2007; 5 (Suppl. 02) 65-84.
92 McDermott CL, Hsieh AA, Sweet ES, Tippens KM, McCune JS. A Pilot Study of Website Information Regarding Aromatase Inhibitors: Dietary Supplement Interactions. J Altern Complem Med 2011; 17 (Suppl. 11) 1043-9.
93 Brauer JA, El Sehamy A, Metz JM, Mao JJ. Complementary and Alternative Medicine and Supportive Care at Leading Cancer Centers: A Systematic Analysis of Websites. J Altern Complem Med 2010; 16 (Suppl. 02) 183-6.
94 van der Marel S, Duijvestein M, Hardwick JC, van den Brink GR, Veenendaal R, Hommes DW, Fidder HH. Quality of web-based information on inflammatory bowel diseases. Inflamm Bowel Dis 2009; 15 (Suppl. 12) 1891-6.
95 Whelan AM, Jurgens TM, Bowles SK, Doyle H. Efficacy of Natural Health Products in Treating Osteoporosis: What is the Quality of Internet Patient Advice?. Ann Pharmacother 2009; 43 (Suppl. 05) 899-907.
96 Kim DY, Lee HR, Nam EM. Assessing cancer treatment related information online: unintended retrieval of complementary and alternative medicine web sites. Eur J Cancer Care (Engl) 2009; 18 (Suppl. 01) 64-8.
97 Walji M, Sagaram S, Sagaram D, Meric-Bernstam F, Johnson C, Mirza NQ, Bernstam EV. Efficacy of quality criteria to identify potentially harmful information: a cross-sectional survey of complementary and alternative medicine web sites. J Med Internet Res 2004; 6 (Suppl. 02) e21.
98 Bernstam EV, Waiji MF, Sagaram S, Sagaram D, Johnson CW, Meric-Bernstam F. Commonly cited website quality criteria are not effective at identifying inaccurate online information about breast cancer. Cancer 2008; 112 (Suppl. 06) 1206-13.
99 Breckons M, Jones R, Morris J, Richardson J. What do evaluation instruments tell us about the quality of complementary medicine information on the internet?. J Med Internet Res 2008; 10 (Suppl. 01) e3.
100 Bernstam EV, Sagaram S, Walji M, Johnson CW, Meric-Bernstam F. Usability of quality measures for online health information: Can commonly used technical quality criteria be reliably assessed?. Int J Med Inform 2005; 74 (7–8) 675-83.
101 Sagaram S, Walji M, Meric-Bernstam F, Johnson C, Bernstam E. Inter-observer agreement for quality measures applied to online health information. Studies in Health Technology and Informatics 2004; 107 (Pt 2) 1308-12.
102 Bonakdar RA. Herbal cancer cures on the Web: noncompliance with The Dietary Supplement Health and Education Act. Fam Med 2002; 34 (Suppl. 07) 522-7.
103 Schmidt K, Ernst E. Assessing websites on complementary and alternative medicine for cancer. Ann Oncol 2004; 15 (Suppl. 05) 733-42.
104 Black M, Hussain H. Hydrazine, cancer, the Internet, isoniazid, and the liver. Ann Intern Med 2000; 133 (Suppl. 11) 911-3.
105 Gelles J. Web marketers to stop making unsubstantiated health claims. The Philadelphia Inquirer [Internet]. 2000
106 Masoni M, Guelfi MR, Gensini GF. Google needs better control of its advertisements and suggested links. Brit Med J 2009; 338.
107 Schifano F, Ricciardi A, Corazza O, Deluca P, Davey Z, Rafanelli C. Gruppo di Ricerca “Psychonaut Web Mapping”. [New drugs of abuse on the Web: the role of the Psychonaut Web Mapping Project]. Riv Psichiatr 2010; 45 (Suppl. 02) 88-93. Italian.
108 Lanier WL. Near-death experiences delivered to your home by your friends on the Internet. Mayo Clin Proc 2004; 79 (Suppl. 08) 979-82.
109 National Health Interview Survey. [cited 2015 Feb 4]. Available from: http://www.cdc.gov/nchs/nhis/nhis_2012_data_release.htm.
110 Greenberg S. Alternative medicine and the Internet. Paediatr Child Health 1999; 4 (Suppl. 08) 539-41.
111 Stone TW, Jumper JM. Information about age-related macular degeneration on the Internet. Southern Med J 2001; 94 (Suppl. 01) 22-5.
112 Ting W, Gross M, Oz MC. The Internet as a research tool in complementary and alternative medicine: A pilot study. Altern Ther Health Med 2002; 8 (Suppl. 03) 84-6.
113 Walji M, Sagaram S, Meric-Bernstam F, Johnson C, Bernstam E. Cancer-related complementary and alternative medicine online: factors affecting information retrieval. Studies in Health Technology and Informatics 2004; 107 (Pt 2) 1318-22.
114 Yamey G. Can complementary medicine be evidence-based?. Western J Med 2000; 173 (Suppl. 01) 4-5.
115 Griffiths P, Sedefov R, Gallegos A, Lopez D. How globalization and market innovation challenge how we think about and respond to drug use: ’Spice’ a case study. Addiction 2010; 105 (Suppl. 06) 951-3.
116 Bower H. Internet sees growth of unverified health claims. BMJ 1996; 313 (7054) 381.
117 Omar HR, Komarova I, El-Ghonemi M, Fathy A, Rashad R, Abdelmalak HD, Yerramadha MR, Ali Y, Helal E, Camporesi EM. Licorice abuse: time to send a warning message. Ther Adv Endocrinol Metab 2012; 3 (Suppl. 04) 125-38.
118 Vickers A. Regulating the practice of CAM – the view from the Web. Complement Ther Med 2001; 9 (Suppl. 02) 127-8.
119 Ekman A, Dickman PW, Klint A, Weiderpass E, Litton JE. Feasibility of using web-based questionnaires in large population-based epidemiological studies. Eur J Epidemiol 2006; 21 (Suppl. 02) 103-11.
120 Huybrechts KF, Mikkelsen EM, Christensen T, Riis AH, Hatch EE, Wise LA, Sorensen HT, Rothman KJ. A successful implementation of e-epidemiology: the Danish pregnancy planning study ‘Snart-Gravid’. Eur J Epidemiol 2010; 25 (Suppl. 05) 297-304.
121 van Gelder MM, Bretveld RW, Roeleveld N. Web-based questionnaires: the future in epidemiology?. Am J Epidemiol 2010; 172 (Suppl. 11) 1292-8.
122 Marriott LK, Nelson DA, Allen S, Calhoun K, Eldredge CE, Kimminau KS, Lucero RJ, PinedaReyes F, Rumala BB, Varanasi AP, Wasser JS, Shannon J. Using Health Information Technology to Engage Communities in Health, Education, and Research. Sci Transl Med 2012; 4 (Suppl. 119) 119mr1.
123 Corley CD, Cook DJ, Mikler AR, Singh KP. Text and structural data mining of influenza mentions in Web and social media. Int J Environ Res Public Health 2010; 7 (Suppl. 02) 596-615.
124 Leaman R, Wojtulewicz L, Sullivan R, Skariah A, Yang J, Gonzalez G. Towards internet-age pharmacovigilance: extracting adverse drug reactions from user posts to health-related social networks. Proceedings of the 2010 Workshop on Biomedical Natural Language Processing; Uppsala, Sweden. 1869976: Association for Computational Linguistics; 2010 p. 117-25.
125 Yom-Tov E, Gabrilovich E. Postmarket Drug Surveillance Without Trial Costs: Discovery of Adverse Drug Reactions Through Large-Scale Analysis of Web Search Queries. J Med Internet Res 2013; 15 (Suppl. 06) e124.
126 Denecke K, Krieck M, Otrusina L, Smrz P, Dolog P, Nejdl W, Velasco E. How to Exploit Twitter for Public Health Monitoring?. Method Inform Med 2013; 52 (Suppl. 04) 326-39.
127 Fox S, Jones S. The Social Life of Health Information. [Internet]. Pew Research Center: Internet, Science & Tech. 2009 [cited 2015 Feb 04]. Available from: http://www.pewinternet.org/2009/06/11/the-social-life-of-health-information.
128 Choudhury MD, Morris MR, White RW. Seeking and sharing health information online: comparing search engines and social media. Proceedings of the 32nd annual ACM conference on Human factors in computing systems Toronto, Ontario, Canada: 2557214 ACM; 2014. p. 1365-76.
129 Wang S, Paul MJ, Dredze M. Exploring Health Topics in Chinese Social Media: An Analysis of Sina Weibo: AAAI Conference on Artificial Intelligence. The World Wide Web and Public Health Intelligence 2014 Available from: https://www.aaai.org/ocs/index.php/WS/AAAIW14/paper/view/8721.
130 Arnold E, Lane S, Webert KE, Chan A, Walker I, Tufts J, Rubin S, Poon MC, Heddle NM. What should men living with haemophilia need to know? The perspectives of Canadian men with haemophilia. Haemophilia 2014; 20 (Suppl. 02) 219-25.
131 Yom-Tov E, Gabrilovich E. Postmarket drug surveillance without trial costs: discovery of adverse drug reactions through large-scale analysis of web search queries. J Med Internet Res 2013; 15 (Suppl. 06) e124.
132 Mitchell L, Frank MR, Harris KD, Dodds PS, Danforth CM. The Geography of Happiness: Connecting Twitter Sentiment and Expression, Demographics, and Objective Characteristics of Place. Plos One 2013; 8 (Suppl. 05) e64417.
133 Giles J. Making the Links. Nature 2012; 488 (7412) 448-50.
134 Liang B, Scammon DL. Incidence of online health information search: a useful proxy for public health risk perception. J Med Internet Res 2013; 15 (Suppl. 06) e114.
135 Chomutare T, Arsand E, Fernandez-Luque L, Lauritzen J, Hartvigsen G. Inferring community structure in healthcare forums. An empirical study. Methods Inf Med 2013; 52 (Suppl. 02) 160-7.
136 SUBDUE – Graph Based Knowledge Discovery. Available from: http://ailab.wsu.edu/subdue.
137 Moore NG. Alternative medicine on the Internet. Altern Ther Health Med 1997; 3 (Suppl. 05) 22-4.
138 Pihlak R, Liivand R, Trelin O, Neissar H, Peterson I, Kivistik S, Lilo K, Jaal J. Complementary medicine use among cancer patients receiving radio-therapy and chemotherapy: methods, sources of information and the need for counselling. Eur J Cancer Care (Engl) 2014; 23 (Suppl. 02) 249-54.
139 Eysenbach G, Diepgen TL. Labeling and filtering of medical information on the Internet. Methods Inf Med 1999; 38 (Suppl. 02) 80-8.