DOI: 10.1055/s-00000017

Experimental and Clinical Endocrinology & Diabetes

Issue S 03 · Volume 105 · 1997 DOI: 10.1055/s-002-19246

Session 1: Spontaneous IDDM syndromes and their prevention

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    Buschard, Karsten; Pakkenberg, Bente; Weber, Ulrik; Bock, Troels:

    Encephalomyocarditis (EMC-3M) virus induced diabetes in mice

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    Petersen, Jacob Sten; Enselman, Rachel; Lantry, Megan; De Jongh, Karen; Grossmann, Angelika; Velasco, Ramel; Hansen, Birgit; Ren, Ping; Bailey, Craig; Kindsvogel, Wayne; Dyrberg, Thomas; Forstrom, John:

    A cholera toxoid-insulin conjugate as oral vaccine against spontaneous autoimmune diabetes

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  • Posters

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    Chung, Y. H.; Jun, H. S.; Kang, Y.; Hirasawa, K.; Lee, B. R.; Van Rooijen, N.; Yoon, J.-W.:

    Role of cytokines in the pathogenesis of autoimmune IDDM in KRV-infected DR-BB rats

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    Hirasawa, K.; Jun, H. S.; Maeda, K.; Kawaguchi, Y.; Itagaki, S.; Mikami, T.; Baek, H. S.; Doi, K.; Yoon, J.-W.:

    Role of macrophage-derived cytokines and oxygen free radicals in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice

  • 9
    Sparre, Thomas; Christensen, Ulla Bjerre; Larsen, Peter Mose; Fey, Stephen J.; Mandrup-Poulsen, Thomas; Nerup, Jørn:

    Similarities in expression levels of proteins in IL-1β stimulated BB-DP islets and islets syngrafted to BB-DP rats

  • Session 2: Insulin action in animal models with spontaneous or diet induced NIDDM syndromes

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    Larner, J.; Allen, G.; Sleevi, M.; Price, J.; Rule, G.; Piccariello, T.; Abe, S.; Heimark, D.; Huang, L. C.:

    Molecular mechanism of insulin resistance. Structure and formation of a novel galactosamine disaccharide – A putative insulin mediator

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    Patti, Mary-Elizabeth; Brambilla, Eugenia; Luzi, Livio; Landaker, Edwin J.; Kahn, C. Ronald:

    Differential regulation of insulin signaling by amino acids

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    Ruderman, Neil B.; Saha, Asish K.; Vavvas, Demetrios; Kurowski, Theodore; Laybutt, D. Ross; Kraegen, Edward W.:

    Malonyl CoA fuel sensing mechanism in muscle of insulin resistant rodents

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    Kraegen, E. W.; Oakes, N. D.; Cooney, G. C.; Laybutt, D. R.; Bell, K. S.; Schmitz-Peiffer, C.; Biden, T.; Chisholm, D. J.:

    Muscle lipid availability and insulin resistance

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  • Posters

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    Othmani-Mecif, Khira; Dahmani, Yasmina; Benazzoug, Yasmina; Amraoui, Linda:

    Effects of cafeine and theophylline on lipolysis in isolated adipocytes of diabetic rats

  • Session 3: Immunomodulation, immunogenetics and environmental factors in animal IDDM

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    Satoh, Jo; Miyaguchi, Shuichi; Sakata, Yoshiyuki; Takahashi, Kazuma; Toyota, Takayoshi:

    Lymphotoxin (TNF-β)-mediated resistance to autoimmune diabetes is induced in NOD but not NOD-scid mice and reversed by IL-12

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    Scott, Fraser W.; Burghardt, Karolina; Rastegar, Shila; Zegers, Alexandre; Jee, Penny:

    Oral agents encountered in infancy modify control of diabetes outcome by weaning diets in BB rats

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    Efrat, Shimon; Herrath, Matthias G. von; Oldstone, Michael B.A.; Horwitz, Marshall S.:

    B-cell survival in mouse models of allotransplantation and autoimmunity mediated by adenovirus immunomodulatory genes

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    Homo-Delarche, Françoise; Durant, Sylvie; Throsby, Marc; Amrani, Abdelaziz; Coulaud, Josiane; Dardenne, Mireille:

    Elements modulating glucose homeostasis in the NOD mouse at the prediabetic stage

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    Casteels, Kristina; Waer, Mark; Laureys, Jos; Depovere, Jos; Bouillon, Roger; Mathieu, Chantal:

    1,25(OH)2D3 protects against cyclophosphamide-induced diabetes and enhances apoptosis induced by cyclophosphamide

  • Posters

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    Gunaratnam, Lakshman; Hammond-McKibben, Denise; Karges, Wolfram; Dosch, Hans-Michael:

    Modification of adoptively transferred NOD mouse diabetes by peptide treatment of ICA69 in IDDM

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    Kurrer, Michael O.; Pakala, Syamasundar V.; Hanson, Holly L.; Katz, Jonathan D.:

    B-cell apoptosis in T-cell-mediated autoimmune diabetes

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    Wiest-Ladenburger, Uta; Fortnagel, Anja; Richter, Wiltrud; Moeller, Peter; Reimann, Joerg; Boehm, Bernhard O.:

    Genetic immunization with the autoantigen glutamic acid decarboxylase (GAD) induces a humoral GAD response in BALB/C C57BL/6, and in diabetes-prone NOD mice

  • Session 4: Obesity and NIDDM

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    Campfield, L. Arthur; Smith, Françoise J.; Kochan, Jarema P.; Yagaloff, Keith A.; Burn, Paul:

    Interaction of the OB protein pathway with other brain mechanisms: Impact on metabolic state

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    Cusin, I.; Sainsbury, A.; Zakrzewska, K.; Rohner-Jeanrenaud, F.; Jeanrenaud, B.:

    Loop between hypothalamic neuropeptide Y and leptin: modulation by glucocorticoids and dysfunction in obesity

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    Collier, G. R.; Walder, K.; de Silva, A.; Morton, G.; Zimmet, P.:

    Diabetes, obesity and leptin in the Israeli sand rat (Psammomys obesus)

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    Igel, Michael; Becker, Walter; Joost, Hans-Georg; Herberg, Lieselotte:

    Post-receptor resistance to leptin in New Zealand Obese mice

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    Giacca, Adria; Wiesenthal, Stephanie; Sandhu, Harmanjit; McCall, Richard; Tchipachvili, Vaja; Rashid, Shirya; Lewis, Gary; Shi, Zhi Qing; Vranic, Mladen; Efendic, Suad:

    Hyperinsulinemia, insulin resistance and free fatty acids. The dog model in diabetes and obesity research

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  • Posters

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    Gernigon-Spychalowicz, Thérèse; Berger, Michel; Lécher, Pierre:

    Seasonal changes in sexual function of Psammomys obesus – histocytological studies

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    Smith, Françoise J.; Campfield, L. Arthur; Huzsar, Dennis; Burn, Paul:

    Metabolic state following targeted disruption of the melanocortin-4 receptor in mice

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  • Session 5: Transgenic and gene knockout animals contributing to the elucidation of pathogenesis and dysfunction in IDDM and NIDDM

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    André, Isabelle; Gonzalez, Antonio; Lühder, Fred; Hoglund, Petter; Poirot, Laurent; Benoist, Christophe; Mathis, Diane:

    A “stripped-down” model of autoimmune diabetes

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    Duvillié, Bertrand; Cordonnier, Nathalie; Joshi, Rajiv L.; Jami, Jacques; Bucchini, Danielle:

    Growth retardation, morphogenesis of pancreas and neonatal diabetes mellitus in double homozygous mutant mice lacking insulin

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    Hammond-McKibben, Denise; Gaedigk, Roger; Chen, Hillary; Dosch, Hans-Michael:

    Construction of a reversible demand knock-out mouse to study the function and role of ICA69 in IDDM

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    Sarvetnick, Nora; Balasa, Balaji; Lee, Myung-Shik; Mueller, Regula:

    Regulatory and counterregulatory effectors in IDDM

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    Pakala, Syamasundar V.; Lee Chivetta, Mary; Strots, Olga; Katz, Jonathan D.:

    Effect of TNF-α receptor deficiencies on the development of insulitis and diabetes in NOD mouse

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    Patel, Salil D.; Parry, Sarrah; Cope, Andrew P.; Congia, Mauro; Fugger, Lars; Sonderstrup-McDevitt, Grete:

    Identification of immunodominant T-cell epitopes of human glutamic acid decarboxylase 65 using HLA-DR4 transgenic mice

  • Session 6: Diabetes complications: neuropathy, nephropathy, retinopathy and vasculopathy

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    Yabe-Nishimura, Chihiro; Hashimoto, Yasuhiro; Yamagishi, Shin-Ichiro; Yagihashi, Soroku:

    Renal glomerulus of transgenic mice expressing human aldose reductase

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    Toyota, Takayoshi; Qiang, Xiao Ling; Sagara, Mikio; Satoh, Jo:

    Treatment of diabetic neuropathy with TNF inhibitors

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    Erlanson-Albertsson, C.; Duan, R.; Rippe, C.; Berger, K.:

    Influence of diabetes on intestinal fat digestion

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    Pugliese, Giuseppe; Pricci, Flavia; Romeo, Giulio; Leto, Gaetano; Diaz-Horta, Oscar; Albanese, Eleonora; Cordone, Samantha; Pesce, Carlo; Purrello, Francesco; Di Mario, Umberto:

    Extracellular matrix overproduction vs. altered cell turnover in glomeruli from experimental diabetic rats

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    Sasson, Shlomo; Kredy-Farahan, Lily; Kaiser, Nurit; Reich, Reuven:

    Bovine vascular cells and extracellular matrix interactions: dual effect of hyperglycemia

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    Renaudin, Corinne; Michoud, Edouard; Lagarde, Michel; Wiernsperger, Nicolas:

    Insulin resistance and diabetes modify the microvascular response to glucose infusion

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    Plagemann, Andreas; Harder, Thomas; Rake, Annett; Melchior, Kerstin; Voits, Mechthild; Fink, Heidrun; Rohde, Wolfgang; Dörner, Günter:

    Acquired neuroendocrine disposition to diabetes and obesity due to perinatal quantitative malnutrition in rats

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  • Posters

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    Sima, A. A. F.; Merry, A. C.; Lightle, R.:

    Impaired macrophage recruitment in axotomized diabetic nerve

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    Sima, A. A. F.; Merry, A. C.; Hall, D. E.; Grant, M. B.; Murray, F. T.; Guberski, D.:

    The BBZ/WORDR-rat: A model for Type II diabetic neuropathy

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    Kelly, Darren J.; Berka, Jennifer L.; Allen, Terri J.; Cooper, Mark E.; Skinner, Sandford L.:

    Diabetic renal failure and associated pathology are ameliorated by Perindopril treatment in transgenic Ren-2 rats

  • Session 7: Amylin/IAPP-relation to insulin secretion and action

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    Young, Andrew; Gedulin, Bronislava; Vine, William; Pittner, Richard; Bhavsar, Sunil; Denaro, Maurizio:

    Amylin and its role in metabolic control

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    Clark, Anne; Badman, Michael K.; MacArthur, Diane L. A.; Higham, Claire A.; Hansen, Barbara C.; de Koning, Eelco J. P.:

    Islet amyloid in transgenic mouse and monkey islets; formation and degradation in vivo and in vitro

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    Westermark, Per; Leckström, Arnold; Ma, Zhi; Westermark, Gunilla T.:

    Formation of amyloid fibrils from IAPP

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    Marco, José; Angeles Silvestre, R.:

    Effect of amylin on islet cell secretion

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    Höppener, J. W. M.; Oosterwijk, C.; Shulman, G. I.; Jiménez-Chillarón, J. C.; Guinovart, J. J.; Chico, S.; Gómez-Foix, A. M.; Ahrén, B.; Lips, C. J. M.:

    Human IAPP/amylin overproducing transgenic mice: Characterization of an animal model to study the role of IAPP in the pathogenesis of Type 2 diabetes

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    Beaumont, Kevin; Albrandt, Keith; Moore, Candace; Dilts, Roger; Prickett, Kathryn; Young, Andrew:

    Pharmacology of amylin action

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    Gebre-Medhin, Samuel; Mulder, Hindrik; Pekny, Milos; Törnell, Jan; Westermark, Per; Sundler, Frank; Ahrén, Bo; Betsholtz, Christer:

    Impact of IAPP deficiency on carbohydrate metabolism and insulin release

  • Poster

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    Leckström, Arnold; Östenson, Claes-Göran; Efendic, Suad; Lundquist, Ingmar; Ziv, Ehud; Shafrir, Eleazar; Westermark, Per:

    Disproportionate plasma concentration of islet amyloid polypeptide (IAPP) relative to insulin in the Goto-Kakizaki (GK) rat, the ob/ob mouse and the Psammomys obesus (sand rat)

  • Session 8: Therapeutic approach and pharmacological considerations for the treatment of spontaneous IDDM and NIDDM

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    Gross, David J.; Weiss, Lola; Reibstein, Israel; van den Brand, Joop; Okamoto, Hiroshi; Clark, Anne; Slavin, Shimon:

    Treatment of advanced disease in NOD mice by immunomodulation and expansion of B-cell mass: a combined approach

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    Wilkison, William O.; Kiefer, Laura L.; Zemel, Michael B.; Mountjoy, Kathleen G.:

    Molecular mechanism of agouti-induced obesity: from gene lesion to physiological mechanism

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    Brown, K. K.; Harrington, W. H.; Wiard, B. W.; Collins, S.; Paulik, M.; Lenhard, J.:

    Use of selective β3 and PPARγ agonists for metabolic staging of insulin responsive target tissues both in vivo and in vitro

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  • Session 9: New and recognized animal models of diabetes: particular advantages for specified research topics

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    Peterson, Richard G.; Shaw, Walter N.; Little, Leah A.; Pesek, Joseph F.:

    Syndrome X and NIDDM expression in hybrids of ZDF/Gmi-fa rats with SHHF/Gmi-facp strain

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    Voigt, Birger; Kovacs, Peter; Klöting, Ingrid:

    BB.LL – a newly established congenic BB rat strain

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    Friedman, Jacob E.; Ishizuka, Tatsuya; Liu, Sha; Bedol, David; Koletsky, Richard J.; Ernsberger, Paul:

    Metabolic consequences of a nonsense mutation in the leptin receptor gene (fak) in the obeses spontaneously hypertensive Koletsky rat (SHROB)

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    Khammar, Farida; Gernigon-Spychalowicz, Thérèse:

    Two rodents in Ben-Abbes with predisposition to diabetes (film)

  • Posters

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    Komeda, K.; Yokoi, N.; Kanazawa, M.; Noda, M.; Kitada, K.; Tanaka, A.; Suda, S.; Ito, H.; Serikawa, T.; Kanazawa, Y.:

    Establishment of two substrains, diabetes prone and non-diabetic, from LETL rats with low incidence of IDDM: some characteristics and genetic analyses

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    Reifsnyder, Peter C.; Partke, Hans-Joachim; Flurkey, Kevin; Leiter, Edward H.; Herberg, Lieselotte:

    Quantitative trait analysis of polygenic NIDDM in reciprocal outcrosses between NZO and NON mice

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  • Session 10: B-cell function and responses in diabetes

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    Prentki, Marc; Roche, Enrique; Segall, Laura; Brun, Thierry; Farfari, Salah; Thumelin, Stéphane; Jeannet, Françoise Assimacopoulos; Esser, Victoria; Denis McGarry, J.; Witters, Lee; Yaney, Gordon; Saha, Asish K.; Corkey, Barbara:

    Glucolipoxia and the etiology of obesity-associated Type 2 diabetes

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    Portha, B.; Serradas, P.; Giroix, MH.; Dachicourt, N.; Morin, L.; Saulnier, C.; Movassat, J.; Marie, J. C.; Gangnerau, M. N.; Bailbé, D.:

    Evolution of B-cell dysfunction in the spontaneously diabetic GK rat: Studies after and before the onset of overt hyperglycemia

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    Östenson, Claes-Göran; Abdel-Halim, Samy M.; Guenifi, Amel; Efendic, Suad:

    Aspects on impaired B-cell function in NIDDM; studies in the spontaneously diabetic GK rat

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    Hellerström, Claes; Eizirik, Decio; Andersson, Arne; Pipeleers, Daniel G.; Sandler, Stellan; Delaney, Carol A.; Welsh, Nils; Flodström, Malin; Tyrberg, Björn; Håkan Borg, L. A.:

    Differences between humans and rodents in the susceptibility to pancreatic cell injury. Implications for the pathogenesis of diabetes

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    Hahn, Hans-Jürgen; Kuttler, Beate; Lucke, Silke; Diamantstein, Tibor; Mathieu, Chantal; Bouillon, Roger:

    Redevelopment of the tolerance to pancreatic B-cells in BB rats

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    Bone, Adrian J.; Hitchcock, Paul R.; Gwilliam, Diane J.; Cunningham, James M.; Barley, Jasmine:

    B-cell responses to insulitis and disease progression in the BB/S rat

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