Molecular basis for insulin resistance: elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation

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Exp Clin Endocrinol Diabetes 1997; 105: 10
DOI: 10.1055/s-0029-1211820

Session 2: Insulin action in animal models with spontaneous or diet induced NIDDM syndromes

Keren Paz¹ , Rina Hemi² , Derek LeRoith³ , Avraham Karasik² , Hannah Kanety² , Yehiel Zick¹

¹Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
²Institute of Endocrinology, Chaim Sheba Medical Center, Tel-Hashomer, Israel
³Diabetes Branch, NIH, Bethesda, MD, USA

Further Information

Publication Date:
15 July 2009 (online)

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