DOI : 10.1055/s-00000094

Zeitschrift für Gastroenterologie

Issue 01 · Volume 51 · January 2013 DOI: 10.1055/s-003-24333


29. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber
Hannover, 25.–26. 1. 2013

Kongresspräsident: Prof. Dr. Michael P. Manns
Abstracts (HTML) List of Authors
  • V_1_01
    Hammerich, L; Heymann, F; Zimmermann, HW; Bangen, JM; Gaßler, N; Huss, S; Liedtke, C; Prinz, I; Lira, SA; Luedde, T; Trautwein, C; Tacke, F:

    Hepatic accumulation of IL-17 producing γδ T cells via chemokine receptor CCR6 restricts liver inflammation and fibrosis by inhibiting hepatic stellate cells

  • V_1_02
    Wuestefeld, T; Pesic, M; Longerich, T; Kang, TW; Yevsa, T; Dauch, D; Potapova, A; Rudalska, R; Rittelmeyer, I; Jarek, M; Geffers, R; Scharfe, M; Klawonn, F; Malek, NP; Schirmacher, P; Ott, M; Vogel, A; Manns, MP; Zender, L:

    In vivo RNAi screening identified MKK4 as a new therapeutic target for the improvement of liver regeneration

  • V_1_03
    Jeliazkova, P; Jörs, S; Lee, M; Zimber-Strobl, U; Ferrer, J; Schmid, RM; Siveke, JT; Geisler, F:

    Notch2 converts hepatoblasts and adult hepatocytes to the biliary lineage via canonical Notch signalling independent of Hes1 in mice

  • P_1_01
    Al-samman, M; Meurer, SK; Sahin, H; Wasmuth, HE; Kisseleva, T; Brenner, D; Trautwein, C; Weiskirchen, R; Scholten, D:

    Effekt von Endoglin auf die Differenzierung und das Signalling in einer neuen Col-GFP-exprimierenden immortalisierten murinen Sternzell-Linie

  • P_1_02
    Bangen, JM; Hammerich, L; Lambertz, D; Huss, S; Barbacid, M; Trautwein, C; Liedtke, C:

    Genetische Inaktivierung von CdK2 in Hepatozyten führt zu erhöhter Fibrogenese in der Leber

  • P_1_03
    Barikbin, R; Quaas, A; Soares, M; Tiegs, G; Sass, G:

    Comparative analysis of inflammation and fibrosis in MDR2/ HO-1 double knockout mice

  • P_1_04
    Borkham-Kamphorst, E; van de Leur, E; Zimmermann, HW; Karlmark, KR; Tihaa, L; Haas, U; Tacke, F; Berger, T; Mak, TW; Weiskirchen, R:

    Protective effects of Lipocalin-2 (LCN2) in acute and chronic liver injury indicate a novel function in liver homeostasis

  • P_1_05
    Böttger, J; Zellmer, S; Scheller, J; Ueberham, E; Rose-John, S; Gebhardt, R:

    Hyper-Interleukin-6 dependent changes in normal and regenerating mouse livers

  • P_1_06
    Böttger, J; Ueberham, E; Zellmer, S; Scheller, J; Rose-John, S; Gebhardt, R:

    Untersuchungen zum Einfluss von Glial-fibrilaric-acidic-protein (GFAP) am Umbau der Mausleber

  • P_1_07
    Bowe, A; Schievenbusch, S; Curth, HM; Goeser, T; Nierhoff, D:

    Expression of the novel stem/progenitor cell marker Neighbor of Punc E 11 after acute and chronic liver injury in the adult mouse liver

  • P_1_08
    Cubero, FJ; Zhao, G; Hatting, M; Nevzorova, YA; Boekschoten, MV; Drvarov, O; Roskams, T; Müller, M; Davis, RJ; Trautwein, C:

    Hepatic Stellate Cells-derived JNK1 is a crucial mediator

  • P_1_09
    Cubero, FJ; Zhao, G; Nevzorova, YA; Hatting, M; Hermanns, N; Schäfer, F; Drvarov, O; Gaßler, N; Liedtke, C; Trautwein, C:

    Crosstalk between IKKγ/Nemo and the Jnk genes in the progression from hepatitis to hepatocellular carcinoma

  • P_1_10
    Czech, B; Valletta, D; Saugspier, M; Müller, M; Bosserhoff, A; Hellerbrand, C:

    Effect of increased glucose transporter 1 (GLUT1) expression in activated hepatic stellate cells

  • P_1_11
    Czech, B; Valletta, D; Dettmer, K; Müller, M; Bosserhoff, A; Oefner, P; Hellerbrand, C:

    Functional effects of methylthioadenosine phosphorylase (MTAP) expression in chronic liver disease

  • P_1_12
    Czech, B; Weigand, K; Neumann, I; Müller, M; Reber, S; Hellerbrand, C:

    Combination of psychosocial stress and a NASH-inducing diet in mice

  • P_1_13
    Dorn, C; Kreutz, M; Müller, M; Hellerbrand, C:

    Gender-specific differences in a murine model of non-alcoholic steatohepatitis

  • P_1_14
    Dorn, C; Engelmann, J; Saugspier, M; Hartmann, A; Müller, M; Spang, R; Bosserhoff, A; Hellerbrand, C:

    Increased expression of c-jun in nonalcoholic fatty liver disease

  • P_1_15
    Galante, A; Jagemann, B; Lohse, AW; Lüth, S:

    No evidence for increased intestinal permeability in cirrhosis

  • P_1_16
    Genz, B; Reetz, J; Meier, C; Kowtharapu, BS; Stoll, A; Timm, F; Vollmar, B; Pützer, B; Abshagen, K; Herchenröder, O:

    Adenoviral-mediated specific targeting of hepatic stellate cells as a selective therapeutic approach in liver fibrosis

  • P_1_17
    Glässner, A; Kokordelis, P; Eisenhardt, M; Krämer, B; Wolter, F; Nischalke, HD; Boesecke, C; Strassburg, CP; Rockstroh, JK; Spengler, U; Nattermann, J:

    NK-Zellen aus HIV/HCV koinfizierten Patienten besitzen im Vergleich zu HCV monoinfizierten Patienten eine verminderte anti-fibrotische Aktivität

  • P_1_18
    Granzow, M; Klein, S; Schierwagen, R; Heinzen, J; Huss, S; Sauerbruch, T; Trebicka, J:

    beta-Arrestin-2 ist an der hepatischen Fibrogenese beteiligt

  • P_1_19
    Hall, R; Liebe, R; Lammert, F:

    Identifying gene expression networks in hepatic fibrosis

  • P_1_20
    Heinrichs, D; Berres, ML; Nellen, A; Fischer, P; Trautwein, C; Wasmuth, HE; Sahin, H:

    Macrophage inflammatory protein-1α shows profibrotic effects in two experimental liver fibosis

  • P_1_21
    Hintermann, E; Ehser, J; Bayer, M; Pfeilschifter, J; Christen, U:

    Induction of hepatic fibrosis by an adenovirus encoding the human liver autoantigen cytochrome P450 2D6

  • P_1_22
    Hochrath, K; Goebel, R; Hiththetiya, K; Stokes, C; Lammert, F:

    Vitamin D modulates biliary fibrosis in ABCB4 deficient mice

  • P_1_23
    Jörs, S; Jeliazkova, P; Ringelhan, M; Ferrer, J; Schmid, RM; Siveke, JT; Geisler, F:

    Adult HNF1beta+ cells give rise to oval cells but do not significantly contribute to normal homeostasis or injury repair of hepatocytes in mice

  • P_1_24
    Kegel, V; Schulz, T; Burkhardt, B; Haase, A; Zellmer, S; Luch, A; Seehofer, D; Glanemann, M; Nüssler, A; Damm, G:

    Establishment of a human in vitro model to investigate inflammatory immune reactions between Kupffer cell activation and hepatocyte damage – an approach to study DILI

  • P_1_25
    Kirstein, MM; Puls, F; Krech, T; Schlue, J; Dämmrich, ME; Pischke, S; Kreipe, HH; Manns, MP; Vogel, A:

    The clinical presentation and prognosis of patients with Congenital Hepatic Fibrosis

  • P_1_26
    Klein, S; Grace, J; Granzow, M; Schierwagen, R; Masing, N; Herath, C; Burell, L; Angus, P; Sauerbruch, T; Trebicka, J:

    Intramural gebildetes Angiotensin 1–7 bewirkt eine splanchnische Vasodilatation via Mas-Rezeptor Stimulierung und induziert dadurch eine vaskuläre Dysfunktion in der Leberzirrhose

  • P_1_27
    Krawczyk, M; Grünhage, F; Lammert, F:

    Elastography-based analysis of variants identified by a genome-wide association study as genetic determinants of liver enzyme activities

  • P_1_28
    Lange, N; Sass, G; Tiegs, G:

    Influence of USP2-Isoforms on TNF-a dependent NFkB activation in primary hepatocytes versus hepatoma cells

  • P_1_29
    Lerche, KS; Mahn, D; Struck, F; Gebhardt, R:

    Die Verteilung der CD44-positiven Vorläuferzellen bei hepatischen Regenerationsprozessen

  • P_1_30
    Liebe, R; Hall, R; Dooley, S; Lammert, F:

    A single quantitative trait locus on mouse chromosome 11 modifies in vitro hepatocyte susceptibility to TGF-β and in vivo fibrogenesis following CCl4 injections

  • P_1_31
    Mahli, A; Saugspier, M; Thasler, WE; Müller, M; Hellerbrand, C:

    In vitro and in vivo models for irinotecan induced steatohepatitis

  • P_1_32
    Mahli, A; Thasler, WE; Müller, M; Hellerbrand, C:

    A novel in vitro model for joint effects of alcohol and free fatty acids on hepatocellular steatosis and inflammation

  • P_1_33
    Mogler, C; Wieland, M; Hu, J; Sivanandam, V; Korn, C; Arnsperger, T; Neumann, A; Longerich, T; Schirmacher, P; Augustin, HG:

    Control of hepatic stellate cells of liver health and disease

  • P_1_34
    Moriconi, F; Malik, IA; Amanzada, A; Ramadori, G; Hess, CF:

    Rat model of long term effects after fractionated (2Gy/day) 60Gy irradiation of rat liver

  • P_1_35
    Nevzorova, YA; Hu, W; Haas, U; Freimuth, J; Tacke, F; Trautwein, C; Liedtke, C:

    Novel findings in an old model: Overexpression of c-myc in hepatocytes promotes the activation of hepatic stellate cells and facilitates the onset of liver fibrosis

  • P_1_36
    Nischalke, HD; Berger, C; Luda, C; Wolter, F; Krämer, B; Glässner, A; Eisenhardt, M; Nattermann, J; Sauerbruch, T; Strassburg, CP; Spengler, U:

    Der rs4240624 Polymorphismus im PPP1R3B Gen zeigt keinen Einfluss bei alkoholischer Zirrhose und hepatozellulärem Karzinom

  • P_1_37
    Noetel, A; Elfimova, N; Becker, D; Nürnberg, P; Teufel, A; Wasmuth, HE; Dienes, HP; Odenthal, M:

    Next generation sequencing of the Ago2 interacting transcriptome identified chemokine family members as novel targets of neuronal microRNAs in hepatic stellate cells

  • P_1_38
    Pasupuleti, S; Roderfeld, M; Roeb, E:

    Bone marrow transplantation (BM-Tx) of CD117+ cells in Abcb4 knockout mice

  • P_1_39
    Pathil-Warth, A; Ludwig, J; Chamulitrat, W; Stremmel, W:

    Hemmung der Aktivierung LPS- und IL-6-vermittelter, pro-fibrogener Signalwege in hepatischen Sternzellen durch Ursodeoxycholyl Lysophosphatidylethanolamid (UDCA-LPE)

  • P_1_40
    Pinna, F; Sahle, S; Beuke, K; Bissinger, MB; Tuncay, S; D'Alessandro, L; Gauges, R; Timmer, J; Raue, A; Klingmüller, U; Schirmacher, P; Kummer, U; Breuhahn, K:

    Role of protein turnover in NF-κB signalling: A systems biology study on primary hepatocytes

  • P_1_41
    Reinhard, H; Roderfeld, M; Pasupuleti, S; Tschuschner, A; Kopsch, K; Kremer, S; Churin, Y; Roeb, E:

    Etablierung und Charakterisierung eines murinen second Hit- Modells für die virale medikamentös- toxische Leberschädigung

  • P_1_42
    Roderburg, C; Vargas Cardenas, D; Tacke, F; Trautwein, C; Luedde, T:

    Ein Netzwerk TGF-beta-abhängiger miRNAs reguliert die sternzellspezifische Kollagenexpression in der Leberfibrose

  • P_1_43
    Roderfeld, M; Hage, L; Rath, T; Tschuschner, A; Nährlich, L; Schulz, R; Zachoval, R; Roeb, E:

    TIMP-4 und Endoglin sowie die Transiente Elastografie sind für die nicht invasive Diagnostik der Leberbeteiligung bei Zystischer Fibrose geeignet

  • P_1_44
    Sahin, H; Rickert, C; Koenen, RR; Trautwein, C; Wasmuth, HE:

    Platelet Specific Junctional Adhesion Molecule-A Deletion verringert die experimentell induzierte Leberfibrose

  • P_1_45
    Saugspier, M; Dorn, C; Engelmann, J; Weiss, TS; Müller, M; Spang, R; Hellerbrand, C:

    Aging promotes progression of non-alcoholic fatty liver disease in mice

  • P_1_46
    Schaffrath, C; Borkham-Kamphorst, E; van de Leur, E; Tihaa, L; Haas, U; Weiskirchen, R:

    Expression analysis of CCN1/CYR61 in primary liver cells and in models of experimental liver fibrogenesis

  • P_1_47
    Schierwagen, R; Granzow, M; Klein, S; Kowallick, B; Vogt, A; Gonzalez-Carmona, M; Huss, S; Sauerbruch, T; Trebicka, J:

    AT1-Rezeptor vermittelte Aktivierung der Janus-Kinase 2 (JAK2) in myofibroblastischen aktivierten hepatischen Sternzellen wirkt fibrogenetisch und erhöht den Portaldruck

  • P_1_48
    Schlosser, M; Wojtalla, A; Schildberg, FA; Knolle, PA; Singer, MV; Sauerbruch, T; Zimmer, A; Siegmund, SV:

    The novel endocannabinoid noladin ether holds putative anti-fibrotic properties by selectively inducing cell death in hepatic stellate cells

  • P_1_49
    Schumacher, F; Hatting, M; Gaßler, N; Boekschoten, MV; Müller, M; Streetz, KL; Trautwein, C; Kroy, DC:

    Hepatocyte specific deletion of Mesenchymal-epithelial transition factor (c-Met) leads to the development of severe non-alcoholic-steatohepatitis (NASH) in a murine NASH model

  • P_1_50
    Valletta, D; Czech, B; Hellerbrand, C; Müller, M:

    Heterozygous p53 knockout affects development of obesity, insulin resistance and non-alcoholic steatohepatitis in mice fed with a Western type diet

  • P_1_51
    Waidmann, O; Brunner, F; Piiper, A; Zeuzem, S; Kronenberger, B:

    Macrophage activation is a prognostic parameter for variceal bleeding and overall survival in patients with liver cirrhosis

  • P_1_52
    Wang, B; Broering, R; Real, CI; Lutterbeck, M; Gerken, G; Lu, M; Schlaak, JF:

    Activation by Pathogen- and Damage-Associated Molecular Patterns Regulates the Expression of RANTES in Primary Hepatic Stellate Cells

  • P_1_53
    Wang, J; Xu, W; Deng, X; Tuma, S; Stremmel, W; Chamulitrat, W:

    Hepatic hypolipidemia in phospholipase A2 VIA-null mice mediates apoptosis, chronic persistent hepatitis, and sensitivity for autoimmune hepatitis

  • P_1_54
    Weiskirchen, R; MM, P; Gaßler, N; Becker, S:

    Establishment of novel innovative bioimaging techniques of metals by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) for diagnosis of liver damage

  • P_1_55
    Weiskirchen, R; Meurer, S; Xu, L; Friedman, S; Bergmann, C:

    Defining the genetic characteristics of human hepatic stellate cell line LX-2 by spectral karyotyping and short tandem repeat genotyping

  • P_1_56
    Weng, HL; Liu, Y; Shen, Z; Xu, MY; Liebe, R; Zimmer, V; Lammert, F; ten Dijke, P; Lu, LG; Li, Y; Dooley, S:

    Notch signaling participates in liver fibrosis

  • P_1_57
    Wertenbruch, S; Großarth, V; Kaldenbach, M; Bennek, E; Heinrich, D; Zhao, G; Sellge, G; Trautwein, C; Brandenburg, LO; Streetz, KL:

    Die Rolle des Antimikrobiellen Peptides LL-37/CRAMP in der Leberfibrose

  • P_1_58
    Yagmur, E; Haumann, M; Koch, A; Lutz, H; Trautwein, C; Tacke, F:

    Evaluation of an automated hyaluronan latex agglutination assay enables the implementation of routine laboratory HEPASCORE calculation

  • P_1_59
    Yagmur, E; Helden, J von; Roelofs, S; Haumann, M; Millonig, G; Seitz, HK; Müller, S:

    Automatisierung des Hepascore zur non-invasive Beurteilung des Fibrosegrades: Eine klinische Evaluation der mechanisierten immunturbidimetrischen Hyaluronanbestimmung

  • P_1_60
    Yuan, Q; Waern, J; Sharma, AD; Manns, MP; Ott, M:

    Matrix metalloproteinase 14 (MMP14) over-expression increases invasiveness and engraftment of transplanted hepatocytes