Single nucleotide polymorphisms in the VKORC1 gene and the risk of stroke in the Southern German population

Marie-Luise Arnold; Christoph Lichy; Inge Werner; Alexander Radbruch; Simone Wagner; Caspar Grond-Ginsbach

doi:10.1160/TH07-10-0617

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2008; 100(04): 614-617
DOI: 10.1160/TH07-10-0617

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

Single nucleotide polymorphisms in the VKORC1 gene and the risk of stroke in the Southern German population

Authors

Marie-Luise Arnold

¹Department of Neurology, University of Heidelberg, Heidelberg, Germany
Christoph Lichy

¹Department of Neurology, University of Heidelberg, Heidelberg, Germany
Inge Werner

¹Department of Neurology, University of Heidelberg, Heidelberg, Germany
Alexander Radbruch

¹Department of Neurology, University of Heidelberg, Heidelberg, Germany
Simone Wagner

¹Department of Neurology, University of Heidelberg, Heidelberg, Germany
Caspar Grond-Ginsbach

¹Department of Neurology, University of Heidelberg, Heidelberg, Germany

Abstract

Summary

Variation in the gene that encodes the vitamin K epoxide reductase subunit 1 (VKORC1) was recently proposed as a genetic risk factor for stroke in a Chinese population. In this ethnic group, only two common haplotypes were observed, with the C-allele of the polymorphism rs2359612 (VKORC1: c.283+837C>T) associated with stroke and other cardiovascular diseases. Recently, the influence of VKORC1 haplotypes on venous thrombosis and coronary heart disease was analyzed in study populations from France and Northern Germany. We studied the frequencies of theVKORC1 haplotypes in a series of young (<50 years, n = 158) patients with ischemic stroke from Southern Germany. The data were compared with findings from age-matched healthy control subjects from the same population (n = 213). In a replica study we also analysed older stroke patients (>50 years, n = 135) and matched control subjects (n = 113). Neither in the young population, nor in the replica study, we observed significant differences in VKORC1 haplotype distributions between healthy control subjects and patients with ischemic stroke. Our data do not confirm the association between polymorphism in the VKORC1 gene and stroke in the German population.

Keywords

Stroke - vitamin K epoxide reductase - haplotype - SNP

Full Text

References

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