DOI : 10.1055/s-00000094

Zeitschrift für Gastroenterologie

Issue 01 · Volume 58 · January 2020 DOI: 10.1055/s-009-45326

Deutsche Arbeitsgemeinschaft zum Studium der Leber (GASL)
36. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber
Mainz, 14.–15.02.2020

Kongresspräsident: Prof. Dr. Peter Galle
Abstracts (HTML) List of Authors
5.4
Filpe, P; Wöstemeier, A; De Martin, E; Weidemann, S; Taubert, R; Schramm, C; Lohse, AW; Herkel, J; Sebode, M: Aberrant expression of activation regulators CBL-B, CTLA-4 and PD-1 in intrahepatic Teff cells in autoimmune hepatitis
5.5
Michael, D; Dominik, P; Sainitin, D; Pamela, F; Rupert, Î; Mathias, H; Ansgar, L; Roland, R; Percy, K: Autoaggression of FOXO1lowCXCR6hiCD8+ T cells causing liver pathology in NASH
5.6
Karatayli, E; Weber, SN; Karatayli, SC; Hall, RA; Dooley, S; Lammert, F: Il-2, Il-22 and Rantes upregulation in a new mouse model of bacterial infection related acute-on-chronic liver injury
5.7
Zoldan, K; Killmer, S; Smits, M; Russ, M; Hofmann, M; Thimme, R; Boettler, T: HCV-specific CD4 T cells show strong Tfh functionality after DAA-mediated viral clearance
5.8
Pfister, D; Nunez, N; Sinha, A; Weiner, A; Deckowska, A; Pinter, M; Govaere, O; Müller, F; Anstee, QM; Entgleitner, T; Rad, R; Pinyol, R; Torrecilla, S; Dudek, M; Knolle, P; Weber, A; Lengenhagger, D; Llovet, JM; Amit, I; Meissner, F; Becher, B; Heikenwälder, M: Adverse effects of PD-1 targeted immunotherapy in NAFLD-triggered HCC
5.9
Krzikalla, D; Leypoldt, L; Laschtowitz, A; Schwinge, D; Schramm, C; Lohse, AW; Herkel, J; Carambia, A: Systemic CD4 T cell tolerance induction in the liver depends on interferon-γ and CTLA-4
5.10
Poch, T; Krause, J; Glau, L; Liwinski, T; Casar, C; Ahrenstorf, AE; Hess, LU; Ziegler, AE; Martrus, G; Lunemann, S; Sebode, M; Schwinge, D; Krebs, CF; Franke, A; Fischer, L; Altfeld, M; Lohse, AW; Tolosa, E; Gagliani, N; Schramm, C: Single cell RNA sequencing reveals naïve T cells ready for effector function in livers of Primary Sclerosing Cholangitis
5.11
Csernalabics, B; Smits, M; Zoldan, K; Panning, M; Neumann-Haefelin, C; Thimme, R; Boettler, T: Cytokine patterns of newly identified HEV-specific CD4 T cell epitope
5.12
Riedl, T; Faure-Dupuy, S; Hizir, Z; Neuhaus, K; Farhat, R; Reisinger, F; Zhuang, X; Schönung, M; Stadler, M; Wettengel, J; Barnault, R; Parent, R; Prokosch, S; Schneider, M; Unger, K; Stottmeier, B; Schirmacher, P; Lipka, D; McKeating, J; Protzer, U; Durantel, D; Lucifora, J; Dejardin, E; Heikenwälder, M: Oxygenation and miR138-5 p act as rheostats in APOBEC3B-mediated Hepatitis B Virus control
5.13
Kallin, N; Bosch, M; Donakonda, S; Manske, K; Wohlleber, D; Knolle, P: Development of liver-resident CD8 T cells during persistent viral liver infection results in functional adaptation
5.14
Namineni, S; O'Connor, T; Faure-Dupuy, S; Johansen, P; Riedl, T; Liu, K; Xu, H; Singh, I; Shinde, P; Li, F; Pandyra, A; Sharma, P; Ringelhan, M; Muschaweckh, A; Borst, K; Blank, P; Lampl, S; Durantel, D; Farhat, R; Weber, A; Lenggenhager, D; Kündig, TM; Stäheli, P; Protzer, U; Wohlleber, D; Holzmann, B; Binder, M; Breuhahn, K; Abdullah, Z; Rolland, M; Dejardin, E; Lang, PA; Lang, KS; Karin, M; Lucifora, J; Kalinke, U; Knolle, PA; Heikenwalder, M: A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control
5.15
Allweiss, L; Giersch, K; Pirosu, A; Volz, T; Lütgehetmann, M; Dandri, M: Both interferon and siRNA treatments promote reappearance of SMC5/6 complex but have different impact on cccDNA
5.16
Ibidapo-Obe, O; Stengel, S; Köse-Vogel, N; Quickert, S; Reuken, P; Busch, M; Bauer, M; Stallmach, A; Bruns, T: Inflammatory peritoneal MAIT cells accumulate during the early phase of spontaneous bacterial peritonitis
5.17
Neumann, K; Ochel, A; Heinrich, F; Schoedsack, M; Tiegs, G: The alarmin IL-33 drives a ST2+ Treg-mediated anti-inflammatory immune response during immune-mediated hepatitis
5.18
Preti, M; Schlott, L; Luebbering, D; Krzikalla, D; Müller, AL; Schwinge, D; Weidemann, S; Lohse, AW; Weiler-Normann, C; Schramm, C; Carambia, A; Herkel, J: Autoimmune hepatitis in mice is enabled by insufficient deletion of autoreactive CD4 T cells and plasticity of Tregs
5.19
Luo, X; Lu, M; Baba, HA; Gerken, G; Wedemeyer, H; Broering, R: Hippo signaling counter regulates early innate immunity in hepatocytes exposed to Hepatitis B virus
5.20
Rueschenbaum, S; Queck, A; Schwarzkopf, K; Brüne, B; Welsch, C; Wedemeyer, H; Zeuzem, S; Weigert, A; Lange, C: Cirrhosis and acute-on-chronic liver failure are linked with aberrant expression of co-stimulatory markers on T-cells
5.21
Hensel, N; Wieland, D; Gu, Z; Sagar, S; Jechow, K; Kemming, J; Bengsch, B; Neumann-Haefelin, C; Bartenschlager, R; Conrad, C; Gruen, D; Ishaque, N; Hofmann, M; Thimme, R: Persistence of a transcriptional chronic scar on HCV-specific CD8+ T cells after DAA-mediated antigen removal
5.22
Kellerer, M; Schramm, C; Tiegs, G; Horst, AK: Soluble CEACAM1 induces activation of STAT5, Foxp3 expression and proliferation of Tregs in DC- T cell cocultures
5.23
Moll, K; Weidemann, S; Huber, S; Tiegs, G; Horst, AK: Pyruvate kinase M2-deficiency in T cells leads to exacerbation of ConA hepatitis and alterations of T cell polarization
5.24
Winkler, F; Hensel, N; Martin, B; Villa, M; Pearce, EL; Hofmann, M; Thimme, R; Bengsch, B: Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis
5.25
Stengel, S; Quickert, S; Ibidapo-Obe, O; Steube, A; Köse-Vogel, N; Yarbakht, M; Reuken, P; Deshmukh, S; Stallmach, A; Bruns, T: CD206 expression characterizes an inflammatory, resident human peritoneal macrophage subset in decompensated cirrhosis
5.26
Adenugba, A; Kupke, P; Schemmerer, M; Hornung, M; Schlitt, H; Geissler, E; Wenzel, J; Werner, J: In-vitro Activation and anti-viral Function of Innate NK cells in HEV Infection
5.27
Buescher, G; Ozga, AK; Addo, M; Lohse, A; Pischke, S; Horvatits, T: Vergleich der Hepatitis E Seroprävalenz und Virämie zwischen HIV- und Transplant-Patienten
5.28
Khera, T; Du, Y; Hengst, J; Deterding, K; Hardtke, S; Strunz, B; Bjorkstrom, N; Port, K; Manns, MP; Cornberg, M; Wedemeyer, H: Soluble inflammatory molecules do not completely normalize despite early treatment of acute symptomatic hepatitis C
5.29
Rufinatscha, K; Stindt, S; Dobner, J; Ehlting, C; Häussinger, D; Bode, JG: The Hepatitis C Virus influences CXC chemokine expression of infected host cells in response to IL-1β
5.30
Heilig, J; Stindt, S; Ehlting, C; Häussinger, D; Bode, J: Neuregulin-1 down-regulates expression of ErbB3 expression in hepatoma cell lines at the level of transcription
5.31
Hinrichsen, H; Stoehr, A; Cornberg, M; Klinker, H; Heyne, R; John, C; Simon, KG; Bilzer, M; Guenther, V; Witte, V; Zeuzem, S: Real-world efficacy of EBR/GZR in HCV GT1 patients with multiple comorbidities and medications: results from the DHC-R
5.32
Lohr, C; Missing, L; Ehlting, C; Häussinger, D; Bode, JG: The inflammatory mediators IL-1β and TNFα prevent CDCA-induced BSEP expression via induction of chemokines
5.33
Schattenberg, J; Stoehr, A; Cornberg, M; Klinker, H; Heyne, R; John, C; Simon, KG; Bilzer, M; Guenther, V; Witte, V; Zeuzem, S: Real-world efficacy of elbasvir/grazoprevir in HCV GT1 infected diabetics: results from the German Hepatitis C Registry
5.34
Casper, M; Reichert, M; Grünhage, F; Lammert, F: Ribavirin-Dauertherapie als Therapieoption bei chronischer Hepatitis E Virus-Infektion
5.35
Christoph, S; Willuweit, K; Hilgard, G; Gerken, G; Wedemeyer, H; Kahraman, A: Long-term course of a patient with overlap hepatitis C and IgG4-related cholangitis