Klinische Pädiatrie

Issue 03 · May 2020

eFirst
Issue
33. Jahrestagung der Kind-Philipp-Stiftung für pädiatr. onkolog. Forschung
Wilsede, 27.03.2020

Prof. Marschalek

Abstracts (HTML) Abstracts (PDF) List of Authors
- Abstracts
Malouf, C; Sahm, F; Landua, SL; Halsey, C; Ottersbach, K: miR-128a and miR-130b determine lineage choice and leukemia-propagating cell identity in MLL-AF4+ acute leukemia
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Antunes, E; Ottersbach, K: Identification of the cell of origin in infant MLL-AF9 leukaemia
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Siemund, A; Kowarz, E; Marschalek, R: Small changes in the MLL-AF4 fusion protein make a difference
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Wilhelm, A; Marschalek, R: Role of reciprocal fusions in MLL-r acute leukemia: studying t(4;11) fusion proteins
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Kundu, A; Kowarz, E; Marschalek, R: The role of reciprocal fusions in MLL-r acute leukemia: studying t(6;11) fusion proteins
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Gasparoli, L; Virely, C; Cantilena, S; Bartram, J; Inglott, S; De Boer, J; Williams, O: Deciphering STAT3 dependency in paediatric acute lymphoblastic leukemia
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Lenk, L; Carlet, M; Cousins, A; Cario, G; Halsey, C; Jeremias, I; Hobeika, E; Jumaa, H; Alsadeq, A; Schewe, DM: CD79a/CD79b Promote CNS-Involvement and Leukemic Engraftment in Pediatric B-cell Precursor Acute Lymphoblastic Leukemia
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Rademacher, AV; Schewe, DM; Bergh, B; Frielitz, FS: Efficient healthcare for children with cancer using telemedicine in intensive chemotherapy phases
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Barwinski, N; Zeschnigk, M; Thakur, BK; Lohmann, D; Ketteler, P: cf-DNA and EVs: Biomarkers for early detection of second primary malignancies in patients with heritable retinoblastoma
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Minari, JB; Salaudeen, BO; Adebiyi, FD: Efficacy of Allicin on DMBA-Induced BRCA-1 Defective Breast Carcinoma in Wistar Rats
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Müller, K; Vogiatzi, F; Winterberg, D; Rösner, T; Cario, G; Schrappe, M; Peipp, M; Valerius, T; Kellner, C; Schewe, DM: Immunotherapeutic co-targeting of CD38 and CD47 in T-cell acute lymphoblastic leukemia (T-ALL)
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Bhatia, S; Ahlert, H; Dienstbier, N; Schliehe-Diecks, J; Sönnichsen, M; Remke, M; Fischer, U; Hauer, J; Borkhardt, A: Therapeutic stratification of acute leukemia using high throughput drug screening
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Szoltysek, K; Blair, H; Tirtakusuma, R; Nakjang, S; Law, E; McKenzie, L; Vormoor, J; Pal, D; Heidenreich, O: Whole-genome CRISPR screen as a tool to identify mechanism of relapse and potential targets for novel drug combinations
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Swart, LE; Issa, H; Blair, H; Heidenreich, O: Specific targeting of RUNX1/ETO; delivery of siRNA using Lipid Nanoparticles in vitro and in vivo
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Niedermayer, A; Enzenmüller, S; Tausch, E; Stilgenbauer, S; Seyfried, F; Meyer, LH: Characterization of mechanisms of acquired Venetoclax-insensitivity in B-cell precursor acute lymphoblastic leukemia
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Boldrin, E; Gaffo, E; Boer, JM; Claus, R; Plass, C; Den Boer, ML; Debatin, KM; Te Kronnie, G; Bortoluzzi, S; Meyer, LH: MicroRNA - 497~195 cluster suppresses cell cycle progression by targeting CCND3/CDK4 in acute lymphoblastic leukemia
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Helmsauer, K; Valieva, M; Ali, S; Chamorro Gonzalez, R; Schöpflin, R; Schulte, JH; Mundlos, S; Koche, RP; Henssen, AG: Enhancer hijacking on the MYCN amplicon in neuroblastoma
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Mir-Salim, D; Bhayadia, R; Heckl, D; Klusmann, JH: Testing ABT-263 for the treatment of pediatric acute myeloid leukemia
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Werr, LH; Ackermann, J; Kahlert, Y; Fischer, J; Wunderlich, FT; Fischer, M: Investigating the role of activated telomerase in genetically engineered neuroblastoma mouse models
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Diskowski, L; Kubiak, K; Wiese, M; Kramm, CM: The function of CBP/p300 and BET-proteins in dependence of H3.3K27M mutation in diffuse intrinsic pontine glioma (DIPG)
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Weigert, K; Alejo-Valle, O; Labuhn, M; Amstislavskiy, V; Emmrich, S; Ng, M; Yaspo, ML; Heckl, D; Klusmann, JH: Investigating miR-125b target gene Arid3a in trisomy 21-associated leukemogenesis
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Zastrow, J; Wiese, M; Kramm, CM: Comparison of Curcumin and Curcuminoids in terms of mechanisms of action and treatment efficiency in DIPG
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Singh, M; Blair, H; Berry, P; Heidenreich, O: Multi-drug chemotherapy dose optimisation in preclinical leukaemia models using HPLC-MS/MS
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Ng, M; Bhayadia, R; Regenyi, E; Amstislavskiy, V; Yaspo, ML; Heckl, D; Klusmann, JH: CRISPR/Cas9-based screens identify an essential long noncoding RNA locus in pediatric acute myeloid leukemia cells
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Ehl, C; Bräuer-Hartmann, D; Gialesaki, S; Alejo-Valle, O; Issa, H; Regenyi, E; Yaspo, ML; Heckl, D; Klusmann, JH: Mapping chromatin occupancy of GATA1 and RUNX1 isoforms in Down syndrome myeloid leukemia
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Huynh, AKD; Walch-Rückheim, B; Smola, S; Graf, N: Combined infection with oncolytic viruses (OVs) induces synergistic and additive cell death in glioblastoma multiforme (GBM) cell lines
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Law, EW; McKenzie, L; Blair, H; Bulmer, D; Pal, D; Szoltysek, K; Lunec, J; Irving, J; Vormoor, J: High-throughput imaging analysis for drug combination efficacy in childhood acute lymphoblastic leukaemia
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Rajak, J; Wu, Y; Koleci, N; Niemeyer, CM; Erlacher, M: Identification of novel therapeutic approaches in a xenograft model of juvenile myelomonocytic leukemia (JMML)
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Miroshnichenkova, A; Komkov, A; Volchkov, E; Popov, A; Maschan, M; Mamedov, I; Olshanskaya, Y: High-throughput sequencing of Ig/TCR genes for MRD monitoring in B-ALL patients receiving immunotherapy
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Grimm, J; Bhayadia, R; Heckl, D; Klusmann, JH: Overcoming differentiation blockage by inhibition of LSD1 as novel therapeutic strategy in pediatric AML
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Komkov, A; Miroshnichenkova, A; Smirnova, A; Komech, E; Atapina, E; Popov, A; Lebedev, Y; Maschan, M; Olshanskaya, Y; Mamedov, I: A cost-effective quasi single-cell assay for deciphering of clonal architecture of leukemic cells
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Schuschel, K; Helwig, M; Regényi, E; Yaspo, ML; Heckl, D; Klusmann, JH; Hoell, JI: Characterization of RNA-Protein Interaction Networks in Acute Leukemias
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Volz, C; Gottschalk, A; Krumbholz, M; Albert, C; Semper, S; Suttorp, M; Glauche, I; Metzler, M: Therapy assessment of pediatric chronic myeloid leukemia (CML) using combined analyses of RNA/DNA response dynamics
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Schneider, D; Schwarzer, A; Knoess, S; Matzk, S; Amstislavskiy, V; Warnatz, HJ; Jian, Xu; Yaspo, ML; Klusmann, JH; Heckl, D: Ezh2 loss cooperates with loss of Runx1 during leukemogenesis and reactivates a fetal gene signature
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Issa, H; Heckl, D; Klusmann, JH: Rewiring the interplay between GATA1s and secondary mutations in the leukaemogenic transformation
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Blunck, CB; Poubel, CP; Lopes, BA; Mansur, MB; Emerenciano, M: Identification of cellular markers for the IKZF1plus subgroup of B-cell acute lymphoblastic leukemia
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Zeuner, S; Ecker, J; Vollmer, J; Oppermann, S; Oehme, I; Peterziel, H; ElHarouni, D; Hielscher, T; Witt, O; Milde, T: Enhancing the effect of class I HDAC inhibition in MYC amplified group 3 medulloblastoma with novel drug combinations
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von Stebut, J; Bardinet, V; Dorado Garcia, H; Bei, Y; Haase, K; Henssen, A: Genome-wide CRISPRa screen identifies determinants of Actinomycin-D resistance in alveolar rhabdomyosarcoma
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